2006
DOI: 10.2174/138920306775474130
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Survey of Functional Activities of Alpha-fetoprotein Derived Growth Inhibitory Peptides: Review and Prospects

Abstract: Alpha-fetoprotein (AFP), known largely as a growth-promoting agent, possesses a growth-inhibitory motif recently identified as an occult epitopic segment in the third domain. The present study reviews the multiple biological activities of this AFP-derived peptide segment termed the Growth Inhibitory Peptide (GIP), which is a 34-amino acid fragment taken directly from the full-length 590 amino acid molecule. The GIP segment has been chemically synthesized, purified, characterized, and subjected to a variety of … Show more

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Cited by 31 publications
(68 citation statements)
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References 90 publications
(156 reference statements)
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“…Hepatocellular carcinoma (HCC) is the fifth most frequent neoplasm worldwide, and accounts for 5.6% of all human cancers [1][2][3]. There is an increasing incidence of HCC in China, and this neoplasm has become China's second most frequent cause of cancer-related death [4].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Hepatocellular carcinoma (HCC) is the fifth most frequent neoplasm worldwide, and accounts for 5.6% of all human cancers [1][2][3]. There is an increasing incidence of HCC in China, and this neoplasm has become China's second most frequent cause of cancer-related death [4].…”
Section: Discussionmentioning
confidence: 99%
“…Although it has been widely used as a marker in clinical diagnosis, compelling progress made in determining the biological role of AFP has recently attracted considerable interest, as AFP shows a close association with HCC carcinogenesis and the high mortality rate of this tumor [1][2][3]. In addition, there has been increasing focus on the role of AFP in promoting cell growth in cultured cells, and this ''growth factor'' function is yet another intriguing aspect of AFP biology.…”
Section: Introductionmentioning
confidence: 99%
“…Because the AFP-MGF form is unstable, the GIP segment itself has now been synthesized, purified, and characterized as a distinct 34-mer synthetic peptide segment [23] . The 34-mer GIP fragment can inhibit both growth factor and estrogen-induced growth in a concentrationdependent fashion in addition to blocking metastatic-associated activities [24,25] .…”
Section: Protein-encrypted Peptides Ctcs and Metastasismentioning
confidence: 99%
“…The final involvement of GIP with cancer cell activities was demonstrated using in vivo models of human BC xenografts in mice. GIP was reported to suppress cancer growth/proliferation in both xenograft and homograft models of MCF-7, GI-101, MDA-MB-231, and 6WI-1 BC tumors in host mice [25,32] . In the human MDA-MB-231 BC in vivo mouse model, GIP injections resulted in a 3-fold reduction in BC metastasis to the lungs as compared to controls.…”
Section: Biological Activities Of Afp-derived Peptidesmentioning
confidence: 99%
“…При этом обнаружено, что 125 I-АФП в печени, кишечнике и крови интактных животных сохраняется в организме в течение по крайней мере 3 сут. Установленное накопление АФП в различных тканях и органах через 3-5 ч после введения и его длительное присутствие в организме может определять те биологи-ческие эффекты этого белка, которые описаны в литера-туре [1,2,12,13]. Радиоактивно меченный АФП может быть использован для обнаружения опухолей в период от 5 до 24 и даже до 72 ч после его введения в организм.…”
Section: результаты и обсуждениеunclassified