Survey of gastroenteritis in children admitted to hospital in Newcastle upon Tyne in 1971-5.

Pullan, C R; Dellagrammatikas, H; Steiner, H.

doi:10.1136/bmj.1.6061.619

Cited by 9 publications

(2 citation statements)

References 10 publications

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“…Relatively few of the patients in our series were seriously dehydrated and ill. Of all of the 357 admitted with diarrhoea in the 12-month period, only 5 (1.4%) required IV infusion therapy and this was mostly necessitated by complicating disorders rather than severe dehydration. This fits with the current trend in the UK (13,14).…”

Section: Discussionsupporting

confidence: 89%

Safety and Efficacy of Three Oral Rehydration Solutions for Children with Diarrhoea (Edinburgh 1984–85)

et al. 1989

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Of 357 children with acute diarrhoea admitted to the City Hospital, Edinburgh, over a 12-month period, only 5 (1.4%) required IV infusions. Three hundred and nineteen were treated with oral rehydration (OR). Of these 269 were studied in detail and 43% had signs of dehydration, but in none of them was it severe. There were no fatalities. Patients were randomly allocated to treatment with one of three OR solutions in a double blind trial. The solutions had sodium concentrations of 35, 50 and 90 mmol (mEq)/l, and dextrose of 200 (36 g/l), 111 (20 g/l) and 110 (19.8 g/l) mmol/l, respectively. Hypernatraemia was not a clinical problem and only 5 children (2%) were biochemically hypernatraemic on admission. Treatment did not cause clinical hypernatraemia. At the second assessment only 3 children were biochemically hypernatraemic, one from each treatment group, and no one had clinical signs. All three solutions were safe and effective in the relatively mildly dehydrated patients currently seen in the UK.

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Section: Discussionsupporting

confidence: 89%

Safety and Efficacy of Three Oral Rehydration Solutions for Children with Diarrhoea (Edinburgh 1984–85)

et al. 1989

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“…Recent surveys from Hackney (London) and Newcastle upon Tyne show a decline in the duration and severity of infantile gastroenteritis (British Medical Journal, 1977b;Pullan et al, 1977;Tripp et al, 1977) but severe dehydration and prolonged diarrhoea were still common in the very young babies. In the present study only 10% of the children were under 3 months, and from the younger babies other viruses or no pathogens were found in the stools more often than rotavirus.…”

Section: Discussionmentioning

confidence: 99%

A year's experience of the rotavirus syndrome and its association with respiratory illness.

Lewis¹,

Parry²,

Davies³

et al. 1979

Archives of Disease in Childhood

101

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SUMMARY In a hospital study rotavirus was identified in 51 % of 152 children with diarrhoea. These patients showed a clinical pattern that was distinct from patients in whom the diarrhoea was associated with bacteria, other viruses, or no pathogens. A respiratory illness was described in 66 % of rotavirus patients and usually preceded the gastrointestinal symptoms. Vomiting lasted between one and 3 days and was curtailed by substituting the normal diet with clear fluids. Watery diarrhoea continued for 4 or 5 days, even when rehydration was by the intravenous rather than the oral route. Prolonged diarrhoea was rare. Most children infected with rotavirus were under 2 years of age, but dehydration was most severe in infants aged between 12 and 18 months. A clinician can thus recognise the rotavirus syndrome and expect spontaneous recovery if adequate rehydration is maintained for a critical few days.

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Secretion of respiratory syncytial virus inhibitors and antibody in human milk throughout lactation

et al. 1980

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Neutralising inhibitors to respiratory syncytial (RS) virus have been demonstrated in the whey of most samples of human milk tested. Although high titres were secreted in colostra of some mothers (1/10-1/2,560; median 1/40) inhibitor levels in milk collected after the first week of lactation were uniformly low (median 1/10). High neutralising titres correlated with high colostral levels of specific antiviral IgA but, unlike neutralising activity, IgA antiviral antibody persisted in the milk of only four of 18 mothers. Similarly, antiviral IgG and IgM antibodies were not generally detected after the first post-partum week. Differences in antibody secretion among mothers did not correlate with differences in total protein or total immunoglobulin secretion, and appeared to reflect maternal immune status. In one mother a marked rise in specific antiviral IgA and IgG secretions during the second and third months of lactation suggested a response to virus infection. The relevance of maternal immunity and colostral and milk antiviral antibody to protection of breast-fed babies from RS-virus bronchiolitis is discussed.

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Survey of gastroenteritis in children admitted to hospital in Newcastle upon Tyne in 1971-5.

Cited by 9 publications

References 10 publications

Safety and Efficacy of Three Oral Rehydration Solutions for Children with Diarrhoea (Edinburgh 1984–85)

Safety and Efficacy of Three Oral Rehydration Solutions for Children with Diarrhoea (Edinburgh 1984–85)

A year's experience of the rotavirus syndrome and its association with respiratory illness.

Secretion of respiratory syncytial virus inhibitors and antibody in human milk throughout lactation

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