Survey of Patients With Juvenile Diabetes Mellitus

Chute, Arthur L.

doi:10.1001/archpedi.1948.02030020008001

Cited by 8 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A series of reports in the 1950s and 1960s described such patients and provided valuable insights, particularly the suggestion that good glycemic control was a predominant feature of such patients (1)(2)(3)(4). However, the populations were very selective, the methodology for determining complications and risk factors understandably limited by today's standards, and, in general, these studies lacked a comparison group, as did a more recent study by Paz-Guevara etal.…”

mentioning

confidence: 99%

Factors Associated With Avoidance of Severe Complications After 25 Yr of IDDM: Pittsburgh Epidemiology of Diabetes Complications Study I

Orchard

Dorman²,

Maser³

et al. 1990

Diabetes Care

202

117

View full text Add to dashboard Cite

To identify characteristics associated with long-term avoidance of insulin-dependent diabetes mellitus (IDDM) complications, subjects taking part in an epidemiologic natural history study of childhood-onset IDDM, with a duration of disease greater than or equal to 25 yr, were studied. Nineteen percent of 175 subjects had avoided overt nephropathy, definite cardiovascular and peripheral vascular disease, clinical neuropathy, and proliferative retinopathy. Approximately half of the nonrenal complications occurred in the absence of renal disease. Subjects free of these advanced complications were characterized by a longer duration of disease (P less than 0.05), better lipid profile and blood pressure (P less than 0.01), and considerably lower glycosylated hemoglobin levels (P less than 0.001). Health-related behaviors, including recent medical contact, regular glucose monitoring, physical activity in youth, and avoidance of cigarette smoking, did not relate to complication status, although regular (at least weekly) alcohol consumption was more prevalent (P less than 0.05) in those without complications. We conclude that a lower mean glycosylated hemoglobin level is strongly related to the avoidance of all IDDM complications.

show abstract

mentioning

confidence: 99%

Factors Associated With Avoidance of Severe Complications After 25 Yr of IDDM: Pittsburgh Epidemiology of Diabetes Complications Study I

Orchard

Dorman²,

Maser³

et al. 1990

Diabetes Care

202

117

View full text Add to dashboard Cite

show abstract

“…Proteinuria is a common finding in patients with long-standing diabetes mellitus and its incidence varies from 6 to 45% [16][17][18][19][20][21]. Our data demonstrates that all diabetic patients who developed renal failure had significant proteinuria and 70% had the nephrotic syn drome.…”

Section: Discussionmentioning

confidence: 63%

“…Many investigators have indicated that nephropathy develops in patients who have diabetes mellitus for a prolonged period of time [16][17][18][19][20][21][22][23][24][25][26][27]. In our patients with kidney di sease the mean duration of diabetes prior to the onset of the renal dysfunction was 15.5± 1.1 and 12.8±0.8 in the juvenile and adult diabetic, respectively.…”

Section: Discussionmentioning

confidence: 81%

“…Although elevated blood pressure is com mon in diabetic patients with advanced renal disease [16][17][18][19]22], hypertension is not con sidered an essential finding in those reports on diabetic nephropathy [20,21], We have found that hypertension was not present in 119 diabe tics at the time that evidence for renal disease was first detected, but high blood pressure developed with the progression of renal failure in 103 patients. These data provide support for the contention that hypertension in patients with diabetic nephropathy is a complication of the renal disease.…”

Section: Discussionmentioning

confidence: 85%

“…Its incidence as reported in the literature has varied between 45 and 83% in patients who had diabetes for more than 15 years [16][17][18][19][20][21]. Unfortunately, there is not adequate information in these studies on the chronologic relationships between retinopathy and renal disease.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Diabetic Nephropathy

Sg²

1978

Nephron

View full text Add to dashboard Cite

The clinical course of diabetic nephropathy was evaluated in 150 patients and the effect of hemodialysis in 68 of them. Proteinuria was the first sign of renal disease. Once renal dysfunction becomes evident, there is a rapid deterioration leading to dialysis within 3.0 ± 0.2 years. Hypertension and circulatory congestion are common complications. The hypertension is probably volume dependent. Retinopathy was not invariably present at the onset of renal insufficiency but appeared with progression of renal failure. The course during hemodialysis was complicated by continued progression of diabetic vascular disease manifested by vascular access difficulties, worsening of retinopathy and blindness, and cardio- and cerebrovascular deaths. Mortality was higher than in nondiabetic dialysis patients.

show abstract

The Diabetic: His Visual Prognosis

Cordes¹

1952

AMA Arch Ophthalmol

View full text Add to dashboard Cite

Survey of Patients With Juvenile Diabetes Mellitus

Cited by 8 publications

References 5 publications

Factors Associated With Avoidance of Severe Complications After 25 Yr of IDDM: Pittsburgh Epidemiology of Diabetes Complications Study I

Factors Associated With Avoidance of Severe Complications After 25 Yr of IDDM: Pittsburgh Epidemiology of Diabetes Complications Study I

Diabetic Nephropathy

The Diabetic: His Visual Prognosis

Contact Info

Product

Resources

About