Survey of scope of neonatal screening in the United Kingdom

Streetly, Allison; Grant, Carol; Pollitt, R. J.; Addison, G. M.

doi:10.1136/bmj.311.7007.726

Cited by 25 publications

(14 citation statements)

References 4 publications

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“…The current newborn screening programme within England and Wales is remarkable, when compared to many other countries, by its limitation [8]. In most regions only two disorders are included, namely PKU and congenital hypothyroidism.…”

Section: Current Newborn Screening Programmementioning

confidence: 99%

Arguments for early screening: a clinician?s perspective

Walter

2003

European Journal of Pediatrics

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For the clinician, the introduction of an expanded and early newborn screening presents opportunities for improved patient and family care. However, it is important to be aware of possible detrimental effects on families of early screening. Screening tests must have adequate sensitivity and high specificity. Furthermore with early screening, close liaison between the laboratory, clinicians and community services is essential.

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Section: Current Newborn Screening Programmementioning

confidence: 99%

Arguments for early screening: a clinician?s perspective

Walter

2003

European Journal of Pediatrics

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“…Experience of neonatal screening programmes has demonstrated that more cases are being detected by screening than by clinical detection [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14], and this new evidence should be considered when the possibility of adding CAH screening to a national programme is considered [22, 23]. Some of the missed cases have been explained through misinterpretation of the degree of sexual ambiguity [5, 11].…”

Section: Blood Spot 17-ohp Assaysmentioning

confidence: 99%

Evaluation of Neonatal Screening for Congenital Adrenal Hyperplasia

Honour

Torresani²

2001

Horm Res Paediatr

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Neonatal screening for congenital hypothyroidism has been effective in early detection and treatment of the condition. The position with respect to neonatal screening for congenital adrenal hyperplasia has been debated for many years. Some countries have performed congenital adrenal hyperplasia screening for many years, others have conducted pilot studies that were then not adopted. This article endeavours to summarize the complex issues behind decisions whether to screen or not and summarizes the findings of neonatal congenital adrenal hyperplasia screening programmes.

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“…National neonatal screening for phenylketonuria began in 1969 and other conditions have been added [11][12][13]. These programmes aim at 100% coverage at an early age and every live born baby should have a completed screening test by 20 days of age [11].…”

Section: Introductionmentioning

confidence: 99%

Impact of incomplete coverage of neonatal dried blood spot screening on estimating HIV-1 seroprevalence

Hutchinson¹,

Streetly

Grant

et al. 1996

Epidemiol. Infect.

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SUMMARYThe aim of this study was to determine the extent to which selective under-coverage of births to mothers more likely to be at risk of HIV-1 infection will result in a significant underestimation of the true neonatal seroprevalence. Census data, local birth statistics, maternity data and data from the prevalence monitoring programme were used to produce a model to predict the effects of under-coverage in the uptake of neonatal metabolic screening which has been observed in babies with a mother of ethnic group black African. The adjustment factor which allows for under-coverage is the relative inclusion ratio (RIR); the probability that samples from a group at different risk of HIV infection were included in the survey divided by the probability of inclusion for samples from all other babies. The RIR was found to be close to unity (0 97), indicating a minimal bias. Under usual conditions only if the relative inclusion ratio (RIR) declined to values of 0'87 or below would there be a substantial bias. Despite some selective under representation, the results obtained from the Unlinked Anonymous HIV

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Survey of scope of neonatal screening in the United Kingdom

Cited by 25 publications

References 4 publications

Arguments for early screening: a clinician?s perspective

Arguments for early screening: a clinician?s perspective

Evaluation of Neonatal Screening for Congenital Adrenal Hyperplasia

Impact of incomplete coverage of neonatal dried blood spot screening on estimating HIV-1 seroprevalence

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