Survey of the Iron Status of Patients with Type 2 Diabetes Mellitus Attending Hospitals in Jos

Okonkwo, P. O.; Okoye, Z. S. C.

doi:10.9734/ijtdh/2014/10899

Cited by 2 publications

(3 citation statements)

References 44 publications

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“…A consistent finding was reported by several other investigators as well. 6,9,31 Whereas, Dulal in a similar study reported an orthodox finding. 29 The serum hemoglobin level was significantly lower in diabetic patients compared to that in non-diabetic subjects, which is consistent with the findings of other similar studies.…”

Section: Original Articlementioning

confidence: 90%

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Iron Status in Male Type 2 Diabetic Patients and Its Association with Their Glycemic Status

Chowdhury,

Begum,

Chowdhury

et al. 2024

Ibrahim card. med. j.

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Background & objective: Alteration in iron metabolism may occur in diabetic patients especially those who have poor glycemic control. Serum iron is involved in free radical formation associated with hyperglycemia and causes diabetic complications. The present study was undertaken to observe the iron status and its relation with glycemic control in male type 2 diabetic patients. Methods: This cross-sectional analytical study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka from July 2017 to June 2018. A total of 48 diagnosed male type 2 diabetic patients (cases) were recruited from the Out-patient Department (OPD) of Endocrinology based on predefined eligibility criteria. Of them, 24 had good glycemic control (HbA1c level < 7%) (Group B1) and 24 had poor glycemic control (HbA1c level ≥ 7%) (Group B2). To compare the outcome (serum iron status) of these diabetic patients, another 48 age- and BMI-matched healthy non-diabetic male subjects were selected from personal contact as control. While diabetes and glycemic status (fasting blood glucose level, and HbA1c) of the diabetic patients were exposure variables, serum iron, serum total iron binding capacity (TIBC), transferrin saturation, and serum ferritin were the outcome variables. Results: The mean age of the subjects of either study group was around 43 and there was no significant difference between the groups concerning age (p = 0.610). The distribution of BMI and serum creatinine between groups was also similar (p = 0.135 and p = 0.134 respectively). The cases had a significantly higher level of serum iron, transferrin saturation, and an insignificantly lower total iron binding capacity (TIBC) than their non-diabetic peers (p = 0.045, p = 0.036, and p = 0.061 respectively). A comparison of outcome variables among the three groups shows that the groups were significantly heterogeneous in terms of serum iron, TIBC, transferrin saturation, haemoglobin level (p = 0.032, p = 0.012, p = 0.008 and p = 0.018 respectively). The associations were more conspicuous in patients with poor glycemic status. Correlation analyses revealed that while there was a significant linear correlation between serum iron and HbA1c (r = + 0.376, p < 0.01), it was negatively correlated with serum TIBC (r = -0.478, p < 0.001). The glycemic status (HbA1c) was also found to be linearly correlated with serum ferritin and transferrin saturation (r = + 0.354, p = 0.013 and r = + 0.462, p < 0.001 respectively). Conclusion: The study concluded that type 2 diabetic patients have a significantly higher level of serum iron, transferrin saturation, and a lower total iron binding capacity (TIBC) than the non-diabetic healthy subjects, all of which may lead to reduced synthesis of hemoglobin. The compromised iron metabolism is even more evident as the hyperglycemia aggravates. Ibrahim Card Med J 2023; 13 (1&2): 32-39

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Section: Original Articlementioning

confidence: 90%

“…8 Excess iron impairs pancreatic β-cell function and causes β-cell apoptosis. 9 Increased accumulation of iron affects insulin synthesis and secretion from pancreatic β-cells and interferes with hepatic insulin extraction by the liver. 10 Serum ferritin is a reliable marker of body iron stores.…”

Section: Introductionmentioning

confidence: 99%

Iron Status in Male Type 2 Diabetic Patients and Its Association with Their Glycemic Status

Chowdhury,

Begum,

Chowdhury

et al. 2024

Ibrahim card. med. j.

View full text Add to dashboard Cite

show abstract

“…The underlying molecular mechanisms mediating these effects are numerous and not completely understood, but include oxidative stress, modulation of adipokines, and intracellular signal transduction systems [ 33 , 57 ]. Iron deposition also induces insulin resistance by inhibiting glucose uptake in fat and muscle tissues, and by reducing the capacity of the liver to extract insulin, which results in an abnormal increase in hepatic glucose production [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

A farewell to phlebotomy—use of placenta-derived drugs Laennec and Porcine for improving hereditary hemochromatosis without phlebotomy: a case report

Hamada¹,

Hirano

Sugimoto

et al. 2022

J Med Case Reports

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Background Human hepcidin, produced by hepatocytes, regulates intestinal iron absorption, iron recycling by macrophages, and iron release from hepatic storage. Recent studies indicate that hepcidin deficiency is the underlying cause of the most known form of hereditary hemochromatosis. Case presentation A 44-year-old Asian man who developed type 2 diabetes mellitus had elevated serum ferritin levels (10,191 ng/mL). Liver biopsy revealed remarkable iron deposition in the hepatocytes and relatively advanced fibrosis (F3). Chromosomal analysis confirmed the presence of transferrin receptor type 2 mutations (c.1100T>G, c.2008_9delAC, hereditary hemochromatosis type 3 analyzed by Kawabata). The patient received intravenous infusions of Laennec (672 mg/day, three times/week) or oral administration with Porcine (3.87 g/day) for 84 months as an alternative to repeated phlebotomy. At the end of the treatment period, serum ferritin level decreased to 428.4 ng/mL (below the baseline level of 536.8 ng/mL). Hemoglobin A1c levels also improved after treatment with the same or lower dose of insulin (8.8% before versus 6.8% after). Plural liver biopsies revealed remarkable improvements in the grade of iron deposition and fibrosis (F3 before versus F1 after) of the liver tissue. Conclusion The discovery of hepcidin and its role in iron metabolism could lead to novel therapies for hereditary hemochromatosis. Laennec (parenteral) and Porcine (oral), which act as hepcidin inducers, actually improved iron overload in this hereditary hemochromatosis patient, without utilizing sequential phlebotomy. This suggests the possibility of not only improving the prognosis of hereditary hemochromatosis (types 1, 2, and 3) but also ameliorating complications, such as type 2 diabetes, liver fibrosis, and hypogonadism. Laennec and Porcine can completely replace continuous venesection in patients with venesection and may improve other iron-overloading disorders caused by hepcidin deficiency.

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Survey of the Iron Status of Patients with Type 2 Diabetes Mellitus Attending Hospitals in Jos

Cited by 2 publications

References 44 publications

Iron Status in Male Type 2 Diabetic Patients and Its Association with Their Glycemic Status

Iron Status in Male Type 2 Diabetic Patients and Its Association with Their Glycemic Status

A farewell to phlebotomy—use of placenta-derived drugs Laennec and Porcine for improving hereditary hemochromatosis without phlebotomy: a case report

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