Survey on anthelmintic resistance to gastrointestinal nematodes in unorganized goat farms of Tamil Nadu

Manikkavasagan, I.; Binosundar, S.T.; Raman, Muthusamy

doi:10.1007/s12639-013-0335-0

Cited by 16 publications

(10 citation statements)

References 13 publications

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“…Very close are results of a recent Slovakian study [15]. Many studies have demonstrated the existence of AR to the main anthelmintic classes in goat herds outside of Europe, namely in the United States [11,16], Cuba [17], Kenya [18], South Africa [19], Uganda [20], Ethiopia [21], Malaysia [22,23], India [24][25][26], and Pakistan [27].…”

Section: Introductionsupporting

confidence: 70%

Prevalence of anthelmintic resistance of gastrointestinal nematodes in Polish goat herds assessed by the larval development test

et al. 2021

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Background Helminthic infections, in particular those caused by gastrointestinal nematodes (GIN), are found worldwide and are among the most economically important diseases of goats. Anthelmintic resistance (AR) in GIN of goats is currently present worldwide, and single- or multidrug resistant species are widespread. The aim of this study was to determine the prevalence of AR to benzimidazoles (BZ), macrocyclic lactones (ML) and imidazothiazoles represented by levamisole (LEV) in the Polish goat herds by using an in vitro larval development test, which is useful especially in large-scale epidemiological surveys. Results This cross-sectional study was conducted from September 2018 to June 2019 and enrolled 42 dairy goat herds scattered over the entire country. The most commonly used anthelmintic class in goat herds in Poland were BZ (92%), followed by ML (85%) and LEV (13%). BZ-resistant GIN populations were found in 37 herds (88%, CI 95%: 75 to 95%), ML-resistant GIN populations in 40 herds (95%, CI 95, 84 to 99%), and LEV-resistant GIN populations in 5 herds (12%, CI 95%: 5 to 25%). Multidrug resistance involving all three anthelmintic classes was found in 5 herds (12%, CI 95, 5 to 25%). Based on the morphological features of stage 3 larvae the main resistant GIN turned out to be Haemonchus contortus and Trichostrongylus spp. The use of BZ and frequency of anthelmintic treatments were significantly related to the presence of AR to BZ in Polish goat herds. Conclusions This cross-sectional study demonstrates the existence of AR to BZ, ML and LEV on Polish goat farms. Resistance to BZ and ML is widespread, while AR to LEV is currently at a low level. A considerable proportion of herds harbours multidrug resistant GIN, which requires further consideration. An effective anthelmintic treatment strategy, reasonable preventive measures and better understanding of the resistance-related management practices by farmers and veterinarians may delay further development of AR.

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Section: Introductionsupporting

confidence: 70%

Prevalence of anthelmintic resistance of gastrointestinal nematodes in Polish goat herds assessed by the larval development test

et al. 2021

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“…The odds ratio for relative risk of getting H. contortus egg was 0.133 (0.07-25; 95% CI) after treatment with IVM as compared to control. In other studies, benzimidazole-resistant H. contortus (Jeyathilakan et al 2003) and multiple anthelmintic resistances in H. contortus against benzimidazole and LEV (Godara et al 2011;Jaiswal et al 2013;Manikkavasagan et al 2013) were documented. However, faecal cultures from IVM-treated group revealed significantly high (69%) number of Trichostrongylus species, which was having meagre (5%) presence before treatment.…”

Section: Resultsmentioning

confidence: 90%

“…Several cases of benzimidazole group drug resistance have been reported in goats (Chartier et al 2001;Jaiswal et al 2013). Levamisole has also been reported to be losing its efficacy in caprine species during recent years particularly in Indian sub-continent (Godara et al 2011;Manikkavasagan et al 2013;Jaiswal et al 2013). Suspicions of IVM resistance, however, are less commonly documented in India and world (Paraud et al 2010;Jaiswal et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Emergence of multiple resistances against gastrointestinal nematodes of Mehsana-cross goats in a semi-organized farm of semi-arid region of India

Gelot

Singh

Shyma

et al. 2015

Journal of Applied Animal Research

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Faecal samples from 140 adult goats were collected and positive samples were examined quantitatively; goats having at least 500 eggs/g of faeces were selected and randomly divided into four groups. Faecal egg count reduction test was used to detect the efficacy of albendazole (ALB), levamisole (LEV) and ivermectin (IVM) in goats naturally infected with gastrointestinal nematodes in a semi-organized farm located in semi-arid region of Gujarat, India. ALB, LEV and IVM reduced faecal egg counts on 14th day post-treatment varied from 53% to 76%, revealing presence of resistance of worms to all these drugs. Finding IVM resistance in gastrointestinal nematodes is found to be alarming. Pre-treatment faecal culture of all the groups collectively revealed Haemonchus spp. as the predominant parasite again post-treatment faecal cultures further emphasize the pre-dominance of H. contortus in ALB-and LEV-treated groups. However, faecal cultures from IVM-treated group revealed predominance of Trichostrongylus species which were scarce in pre-treatment group. Study further reveals that only ALB was found to be effective against Oesophagostomum spp., and most of the gastrointestinal nematodes were found to have some degree of resistance against rest of the other drugs used in goats.

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“…Our observations are in line with the findings of Sharma et al (2015) who reported 57.44% and 70.87% FECR percentage on 7 th and 14 th day post treatment, respectively against H. contortus in goats of Jammu region. There are many reports regarding BZ resistance in goats against GINs from others parts of the country like Uppal et al (1992) ; Ram et al (2007) ; Godara et al (2011) ; Manikkavasagan et al (2015) . The anthelmintic resistance survey of Chandra et al (2015) indicated that the status of BZ resistance is in alarming conditions in all parts of the Uttar Pradesh, India.…”

Section: Resultsmentioning

confidence: 99%

Multiple anthelmintic resistance in gastrointestinal nematodes of Caprines on Mountain Research Centre for Sheep and Goat at Kashmir Valley, India

Bihaqi

Allaie

Banday

et al. 2020

Parasite Epidemiology and Control

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The study was conducted to evaluate the status of anthelmintic resistance in Gastro-Intestinal Nematodes (GINs) of goats at an organized farm located in Kashmir, as there is no report of resistance against these parasites of goats from this temperate region, although it has been reported worldwide including India. Caprines reared at this farm exhibited reduced efficacy to multiple anthelmintics following treatments with Fenbendazole (FBZ), Closantel and Ivermectin (IVM) in Faecal Egg Count Reduction Test (FECRT). The results suggested that the overall efficacy was highest for IVM at 83.5% and 90.0% on 7 th and 14 th day post-treatment, respectively and least for FBZ at 44.3% and 62.5%, respectively, whereas the corresponding figures for closantel were 68.3% and 86.2%, respectively. The pre-treatment faecal culture revealed Haemonchus contortus , Teladorsagia circumcincta and Trichostrongylus colubriformis as predominant strongyles, however, in post-treatment samples, only H. contortus was observed. Further, the infective larvae were subjected to Allele specific PCR (AS-PCR) for accurate diagnosis of BZ resistance. The AS-PCR revealed 52% of H. contortus were homozygous resistant (rr) and 17% were heterozygous (rS) on day “0” before treatment and 100% homozygous resistant (rr) on 7th day post treatment. In both T. colubriformis and T. circumcincta, 100% population was homozygous susceptible (SS) at day “0” before treatment. The overall frequency of resistant (r) allele for H. contortus was 60.5% and for susceptible allele (s) was 39.5%. For T. colubriformis and T. circumcincta the frequency of susceptible allele (s) was 100%. The survey indicated that the GINs of goats on the farm have developed multiple anthelmintic resistance to FBZ, closantel and IVM and the condition is alarming in the farm. Moreover surveillance studies about status of anthelmintic resistance in other farms (Govternment as well as Private) of Kashmir valley should be carried out at large scale to develop effective and sustainable control strategies against GI Nematodes.

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Survey on anthelmintic resistance to gastrointestinal nematodes in unorganized goat farms of Tamil Nadu

Cited by 16 publications

References 13 publications

Prevalence of anthelmintic resistance of gastrointestinal nematodes in Polish goat herds assessed by the larval development test

Prevalence of anthelmintic resistance of gastrointestinal nematodes in Polish goat herds assessed by the larval development test

Emergence of multiple resistances against gastrointestinal nematodes of Mehsana-cross goats in a semi-organized farm of semi-arid region of India

Multiple anthelmintic resistance in gastrointestinal nematodes of Caprines on Mountain Research Centre for Sheep and Goat at Kashmir Valley, India

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