Survey on schizophrenia treatment in Mexico: perception and antipsychotic prescription patterns

Apiquian, Rogelio; Fresán, Ana; Fuente‐Sandoval, Camilo de la; Ulloa, Rosa Elena; Nicolini, Humberto

doi:10.1186/1471-244x-4-12

Cited by 21 publications

(20 citation statements)

References 50 publications

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“…Similar finding was also seen in a pharmacoepidemiological study of drug use in Manipal by Raut et al [17] . The preference maybe attributed to fact that atypical antipsychotics are available since a long time in the market hence the wide knowledge about their indications and dose ranges in the literature may make psychiatrists more comfortable in prescribing these drugs [24] .…”

Section: Short Communicationsmentioning

confidence: 99%

Drug Utilization Study of Psychotropic Drugs among Psychiatric Outpatients in a Tertiary Care Hospital

Chawla¹,

Agarwal²,

Sharma³

et al. 2017

pharmaceutical-sciences

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Chawla, et al.: Drug Utilization Study of Psychotropic DrugsAvailability and utilization of a wide variety of psychotropic drugs is associated with a wide spectrum of adverse drug reactions. To ensure the rational use of psychotropic drugs, it is imperative to monitor their pattern of use. The present study mainly focuses on the pattern of utilization of psychotropic drugs among psychiatric outpatients in a tertiary care hospital. A hospital based cross sectional study was carried out in the psychiatry outpatient department from January to December 2012. A total of 600 cases were studied. Demographic and drug related information was collected. With respect to the psychotropic drug utilization, sedative-hypnotics (42.9 %) were the most commonly prescribed group of psychotropic drugs followed by antidepressants (31.8 %), antipsychotics (19.6 %) and mood stabilizers (5.6 %). Among the sedative hypnotics, clonazepam (51.1 %) and amongst antidepressants, sertraline (28.9 %) and fluoxetine (17.3 %) were the most frequently utilized. The prescription of atypical antipsychotics like risperidone (41 %) and olanzapine (39.8 %) was predominant (95.4 %) over the typical ones. Valproate (54.7 %) was observed to have surpassed the use of lithium (32 %) as a mood stabilizer in bipolar disorders. A substantial increase in the use of anticonvulsants as mood stabilizers was observed. The use of the psychotropic drugs for different indications was in accordance to the current recommendations and guidelines. Newer drugs were being prescribed more often as compared to the conventional medications owing to their better safety and tolerability profiles. The psychotropic drug use in the health facility was a combination of rational and effective practice.

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Section: Short Communicationsmentioning

confidence: 99%

Drug Utilization Study of Psychotropic Drugs among Psychiatric Outpatients in a Tertiary Care Hospital

Chawla¹,

Agarwal²,

Sharma³

et al. 2017

pharmaceutical-sciences

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“…Sería de interés llevar a cabo en nuestro medio un estudio similar a los efectuados por Apiquian y colaboradores 19 en México y Rabinowitz y colaboradores en Israel 22 , para determinar qué factores consideran los tratantes a la hora de elegir un antipsicótico sobre otro, así como también la dosis en la cuál lo indicarán.…”

Section: Discussionunclassified

“…Respecto a Latinoamérica, un estudio mexicano 19 , no documentó el patrón de uso propiamente tal, pero indagó a través de una encuesta a los tratantes sobre sus preferencias de tratamiento. Cabe mencionar que los atípicos ocuparon un papel destacado, siendo la risperidona la preferida para tratar los síntomas negativos y para todo paciente con riesgo de desarrollar signos extrapiramidales.…”

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Prescripción de antipsicóticos atípicos en pacientes hospitalizados de la Clínica Psiquiátrica Universitaria

Silva

2008

Rev. chil. neuro-psiquiatr.

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“…In contrasts, the treatment cost with generic, offpatent typical antipsychotics is in the range of $10 USD. Therefore, atypical antipsychotics are not frequently prescribed in Mexico, and approximately 80% of the patients are treated with typical antipsychotics (Apiquian et al, 2004), while in the USA, more than 80% of the patients are treated with atypicals (Hermann et al, 2002). This lack of accessibility of atypical antipsychotics, largely attributable to price, is not only an issue in Mexico but is likely to be the reality for the majority of the worlds' patients with schizophrenia who live in low-income countries.…”

Section: Discussionmentioning

confidence: 99%

Amoxapine as an Atypical Antipsychotic: A Comparative Study Vs Risperidone

Apiquian

Fresán

Ulloa

et al. 2005

Neuropsychopharmacol

Self Cite

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Amoxapine is marketed as an antidepressant. However, its invitro profile, receptor occupancy and preclinical effects are very similar to atypical antipsychotics. Amoxapine has also shown efficacy as an atypical antipsychotic in open trials. The objective of this study was to compare the antipsychotic and side effect profile of amoxapine and risperidone in a randomised assignment, standardized dosing, doubleblind trial of acutely psychotic patients with schizophrenia. A total of 48 schizophrenic patients were enrolled and randomized in a double-blind 6-week trial to receive either risperidone (up to 5 mg/day) or amoxapine (up to 250 mg/day). Positive, negative, affective symptoms and motor side effects were measured using standardized weekly assessments. Prolactin levels were also determined at baseline and at the end of the study. A total of 39 patients (amoxapine, n ¼ 22; risperidone, n ¼ 21) completed the trial. Both pharmacological treatments, amoxapine 228.0 mg/day (SD ¼ 34.6) and risperidone 4.5 mg/day (SD ¼ 0.7), showed equivalent improvement in positive, negative, and depressive symptoms. Amoxapine was associated with less EPS and less prolactin elevation than risperidone. These data support previous reports about the efficacy of amoxapine as an atypical antipsychotic. Since amoxapine is off-patent, it may be a valuable low-cost alternative to new atypical antipsychotics, particularly in low-income countries where the majority of the patients are still treated with typical antipsychotics.

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Survey on schizophrenia treatment in Mexico: perception and antipsychotic prescription patterns

Cited by 21 publications

References 50 publications

Drug Utilization Study of Psychotropic Drugs among Psychiatric Outpatients in a Tertiary Care Hospital

Drug Utilization Study of Psychotropic Drugs among Psychiatric Outpatients in a Tertiary Care Hospital

Prescripción de antipsicóticos atípicos en pacientes hospitalizados de la Clínica Psiquiátrica Universitaria

Amoxapine as an Atypical Antipsychotic: A Comparative Study Vs Risperidone

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