Survival Analysis of Premature Infants Admitted to Neonatal Int ensive Care Unit (NICU) in Northwest Ethiopia using Semi-Parametric Fr ailty Model

Yehuala, Sheferaw; Ayalew, Salie; Teka, Zinabu

doi:10.4172/2155-6180.1000223

Cited by 9 publications

(27 citation statements)

References 21 publications

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“…All studies were published from 2012 to 2019. Six of the studies identified employed hospital-based cohort designs [24][25][26][27][28][29]; the remaining four applied cross-sectional designs [30,31] ( Table 1).…”

Section: Description Of Studiesmentioning

confidence: 99%

“…The capacity of NICU in terms of bed-size and staffing varied from hospital to hospital. It ranged from16-beds NICU [32] to 50-beds NICU [26] and some hospitals had comprehensive neonatal care that included intensive care, KMC, and isolation rooms [30,24,27,28,26]. It was staffed with medical interns, pediatric residents, physicians, and nurses.…”

Section: Description Of Studiesmentioning

confidence: 99%

“…To determine the proportion of the pooled magnitude of mortality driven by some studies, we conducted three different analysis by excluding studies early neonates which is also large sample [26], on preterm [28,29,27], and both preterm and early neonates [28,29,27,26]. Following the removal of a study on the early neonate, the overall pooled estimate was not changed.…”

Section: Sensitivity Analysismentioning

confidence: 99%

“…Six studies [30,24,31,26,33,25] reported neonatal mortality disaggregated by gestational age and the other three studies [28,29,27] were conducted among preterm neonates. Accordingly, mortality rates were compared among preterm and term/post-term neonates.…”

Section: Preterm Mortalitymentioning

confidence: 99%

“…Three studies reported determinants of preterm mortality among neonates admitted at NICU [29,27,28]. The leading causes of death were PNA [29,27,28], HMD [27,29], and RDS [28,29].…”

Section: Determinants Of Preterm Mortalitymentioning

confidence: 99%

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Magnitude and determinants of newborn mortality in neonatal intensive care unit hospitals in Ethiopia: a systematic review and meta-analysis

Tiruneh¹,

Birhanu²,

Seid³

et al. 2020

Preprint

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Background: In Ethiopia, the neonatal mortality rate has not shown significant changes over time and is among the highest in the world. Exploring the magnitude and the causes of neonatal mortality in the hospital where neonatal intensive care unit is functioning could be supremely important to step towards improving the quality of neonatal care services. Therefore, this review aimed to explore the pooled magnitude and determinates of neonatal mortality in the neonatal intensive care unit hospitals in Ethiopia. Methods : The research team retrieved global peer-reviewed journal articles available as electronic databases including PubMed, Popline, and Scopus databases. Google Scholar, institutional repositories, and Google were used to retrieve grey literature. Random-effects meta-analysis model was used to pool the estimates of the magnitude of mortality among studies. The results were presented as the pooled estimates (odds ratio and proportion) with 95% confidence intervals, at less than 0.05 significant levels. Results: In this review, 10 studies were included with a total of 8,729neonates. Of these, 1,779 (20.4%) neonates died in the neonatal intensive care unit. The pooled neonatal mortality rate was 19.0% (95% CI: 14.0-25.0). The neonatal mortality is three times higher among early age (OR: 2.80; 95% CI: 1.45-5.40) and preterm newborns (OR: 3.27; 95% CI: 2.12-5.07) than their counterparts. Early age of the newborn, prematurity, low birth weight, perinatal asphyxia, mode of delivery, hypothermia, late initiation of breastfeeding, and having antenatal care visits were the main determinants for neonatal mortality. Likewise, perinatal asphyxia, hyaline membrane disease, respiratory distress syndrome, and prematurity were identified as the most determinant and statistically associated with the death of premature neonates admitted to intensive care units.Conclusion: Neonatal mortality in the intensive care unit is high. It is unacceptably high amongst early and preterm neonates. Special care for preterm and early age newborns, timely initiation of breastfeeding, exclusive breastfeeding, and appropriate mode of delivery, essential obstetric and newborn care, and promoting antenatal visits are recommended to reduce neonatal mortality.Protocol registration: The protocol was registered at the International prospective register of systematic reviews (PROSPERO) with registration number CRD42019123195.

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Section: Description Of Studiesmentioning

confidence: 99%

Section: Description Of Studiesmentioning

confidence: 99%

Section: Sensitivity Analysismentioning

confidence: 99%

Section: Preterm Mortalitymentioning

confidence: 99%

“…Three studies reported determinants of preterm mortality among neonates admitted at NICU [29,27,28]. The leading causes of death were PNA [29,27,28], HMD [27,29], and RDS [28,29].…”

Section: Determinants Of Preterm Mortalitymentioning

confidence: 99%

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Magnitude and determinants of newborn mortality in neonatal intensive care unit hospitals in Ethiopia: a systematic review and meta-analysis

Tiruneh¹,

Birhanu²,

Seid³

et al. 2020

Preprint

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Neonatal outcomes of preterm neonates and its predictors in Ethiopian public hospitals: Multicenter prospective follow-up study

Hailemeskel,

Dagnaw,

Demis

et al. 2023

Heliyon

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Escalating the limit of median survival time and predictors of mortality among preterm neonates in Northwest Ethiopia, 2021: a 1-year prospective follow-up study

et al. 2022

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ObjectivesTo examine the survival rate and predictors of mortality among preterm neonates in the neonatal intensive care unit at South Gondar public hospitals, 2021.DesignProspective follow-up study.SettingSouth Gondar public hospitals, Northwest, Ethiopia.ParticipantsWe recruited 283 preterm neonates who were admitted at neonatal intensive care unit at selected hospitals from 15 February 2020 to 22 January 2021.Outcome measuresThe primary outcome measure of this study was the survival rate of preterm neonates in the neonatal intensive care unit. Moreover, the study assessed the predictors for the occurrence of mortality by the Cox-proportional hazard model. Data were entered into Epi data V.4.2 and exported to Stata V.14 statistical software for analysis. The log-rank test determines the survival difference between predictor variables.ResultsA total of 283 preterm neonates, 61 died during the follow-up. Born from antepartum haemorrhage mother (adjusted HR (AHR)=2.2 (95% CI 1.10 to 4.37)), being small weight for gestational age (AHR=4.6 (95% CI 2.22 to 9.53)), not having kangaroo mother care practice initiated (AHR=2.7 (95% CI 1.39 to 7.74)), hypothermia (AHR=4.0 (95% CI 1.96 to 8.30)) and perinatal asphyxia (AHR=3.9 (95% CI 1.97 to 7.94)) were significant predictors of preterm neonate mortality.ConclusionIn this study, the preterm neonates survival rate (78.4%) and the median survival time (21 days) were found to be low. Preventing and managing the predictors, including an antepartum haemorrhagic mother, small weight for gestational age, hypothermia and prenatal asphyxia, is crucial. In addition, more emphasis should be placed on initiating universal kangaroo mother care practice soon after birth to increase the survival of preterm neonates.

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Survival Analysis of Premature Infants Admitted to Neonatal Int ensive Care Unit (NICU) in Northwest Ethiopia using Semi-Parametric Fr ailty Model

Abstract: This study presents an extension of Cox model to frailty model in which the Cox-proportional of baseline hazard and the gamma distribution is used as frailty distribution. The gamma distribution is

Cited by 9 publications

References 21 publications

Magnitude and determinants of newborn mortality in neonatal intensive care unit hospitals in Ethiopia: a systematic review and meta-analysis

Magnitude and determinants of newborn mortality in neonatal intensive care unit hospitals in Ethiopia: a systematic review and meta-analysis

Neonatal outcomes of preterm neonates and its predictors in Ethiopian public hospitals: Multicenter prospective follow-up study

Escalating the limit of median survival time and predictors of mortality among preterm neonates in Northwest Ethiopia, 2021: a 1-year prospective follow-up study

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