Survival and Clinical Aspects for Patients with Chronic Lymphocytic Leukemia in Kermanshah, Iran

Abstract

Chronic lymphocytic leukemia (CLL)is the most common leukemia in adults in Western countries but is relatively rare in Asia. Immune hemolytic anemia, Evan's syndrome, lymphadenopathy, organomegaly and B symptoms are the main complaints of patients in CLL. The present retrospective analysis evaluated a group of 109 patients with CLL over a 9-year period, studying correlations between sex, age and overall survival. The patients were hospitalized in the Clinic of Hematology and Oncology, Kermanshah, Iran, between 2006 and 2014. Data analysis for sex and age was performed using IBM SPSS19 and overall survival was plotted by Kaplan-Meier plot, Log-rank test in Graph Pad prism 5 Software for five-year periods. The mean age of diagnosis for CLL patients was 60.73 years, 59.6% male. Survival rate patients was 64% and mean overall survival was 38.5 months. In the Rai system, fourteen patients (12.8%) had stage ΙΙΙ and twenty eight patients (25.7%) had stage IV. Most frequent clinical features in patients with CLL were lymphadenopathy (38.7%) and organomegaly (34%), respectively. There is not relationship between sex and age in patients but overall survival rate in females was higher than in males. In Asian countries, CLL is more in male and in age above 60 years. Complaints about lymphadenopathy and virus infection are prevalent.

Cost–utility analysis comparing hospital‐based intravenous immunoglobulin with home‐based subcutaneous immunoglobulin in patients with secondary immunodeficiency

“…The mean age of our cohort was 63 years, similar to the 56–64 years reported in the literature . It has been estimated that 52–62% of chronic lymphocytic leukaemia (CLL) patients have hypogammaglobulinaemia at diagnosis , with 17–27·3% having IgG deficiency .…”

Clinical Aspects, Immunophenotypic Analysis and Survival Rate of Chronic Lymphocytic Leukaemia Patients in Erbil City, Iraq

“…9 In Iran, Payandeh et al also reported varying rates of organomegaly (34%) and lymphadenopathy (38.7%). 2 The diversity of clinical presentations in CLL and correlations with ethnicity have been well documented in previous research. 13 The incidence of anaemia and AIHA in the current study (78.1% and 11%, respectively) was comparable to that reported in previous research in which AIHA was documented in up to 11% of late-stage CLL patients, with positive DAT results seen in up to 15% of patients.…”

“…In the current study, the median age at diagnosis of CLL patients in Erbil, Iraq, was similar to that reported in neighbouring countries such as Iran and Turkey (65 years versus 60.73 and 64 years, respectively). 2,9 In contrast, the median age at diagnosis in Western countries is much higher, ranging from 67-72 years old. 1,10,11 However, the frequency of male CLL patients in the current study was identical to that reported in Italy (64%).…”

“…hronic lymphocytic leukaemia (cll) is the most common type of leukaemia among adults in Western countries; however, it is relatively rare in Asia. 1,2 It is characterised by the build-up of lymphocytes in the blood, bone marrow and lymphatic tissue. The median age at diagnosis ranges from 67-72 years and the condition is more common in males.…”

“…The median age at diagnosis ranges from 67-72 years and the condition is more common in males. 1,2 The clinical course of CLL is highly variable, ranging from no symptoms to the rapid development of features of high-risk disease. 3 Lymph node swelling is the most common presenting feature of CLL, although fever, night sweats and weight loss are sometimes seen.…”