Survival and Differentiation of Dopaminergic Mesencephalic Neurons Are Promoted by Dopamine-Mediated Induction of FGF-2 in Striatal Astroglial Cells

Reuss, Bernhard; Unsicker, Klaus

doi:10.1006/mcne.2000.0906

Cited by 39 publications

(31 citation statements)

References 54 publications

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“…We were focusing specifically on D 1 -like receptors, since we have previously shown that the developmental effects of dopamine are mainly mediated via that receptor subtype (Schmidt et al, 1996(Schmidt et al, , 1998Kü ppers et al, 2000). In earlier studies, astrocytes from several brain regions have been reported to express dopamine receptors (Hansson and Rö nnbä ck, 1988;Bal et al, 1994;Zanassi et al, 1999;Reuss and Unsicker, 2000). Although these studies are controversial with respect to the expression of D 1 receptors, they document the potential role of astrocytes in mediating dopaminergic effects.…”

Section: Discussionmentioning

confidence: 92%

“…Despite that capacious information about this dopamine receptor subtype, the functional significance of D 5 receptors in striatal astrocytes remains unknown. Dopamine has been shown to increase the expression of trophic factors in striatal astrocytes such as GDNF and fibroblast growth factor 2 (FGF-2) (Reuss and Unsicker, 2000;Kinor et al, 2001). Both developmental signals interfere with cellular differentiation and cell survival at the striatal level addressing either established dopaminergic connections or the morphological maturation of intrastriatal neurons, respectively (Tomac et al, 1995;Rosser et al, 2000).…”

Section: Discussionmentioning

confidence: 98%

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BDNF‐dependent stimulation of dopamine D₅ receptor expression in developing striatal astrocytes involves PI3‐kinase signaling

Brito

Beyer

Küppers

2004

Glia

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It is well known that brain-derived neurotrophic factor (BDNF) and the early nigrostriatal dopaminergic input are implicated in the regulation of developmental processes in the neostriatum. There is growing evidence that interactions between these developmental signals rather than singular actions are critical for cellular differentiation and compartmentation of the striatum. In the present report, our goal is to identify striatal target cells for BDNF and dopamine. Using primary neuronal and astroglial cell cultures, we have demonstrated that BDNF selectively regulates D(5) but not D(1) receptor expression in astrocytes. This effect was not observed in neurons. Pharmacological approaches indicated that BDNF effects on dopamine D(5) receptor expression were mediated at the intracellular level by an activation of the PI3- but not MAP-kinase cascade. FACS analysis and confocal laser microscopy revealed that the newly synthesized D(5) receptors were integrated into the plasma membrane of astrocytes. Our findings clearly show that developing striatal astrocytes are targets for BDNF. Furthermore, BDNF appears to regulate the dopamine responsiveness of astrocytes. This implicates that functional interactions between BDNF, dopamine, and astrocytes are necessary to warrant proper differentiation of the striatal anlage.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 98%

BDNF‐dependent stimulation of dopamine D₅ receptor expression in developing striatal astrocytes involves PI3‐kinase signaling

Brito

Beyer

Küppers

2004

Glia

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“…and striatal rat astrocytes [42], whereas dopamine agonists increase the secretion of NGF and GDNF in cultured mouse astrocytes [43]. Furthermore, it has been shown that atypical neuroleptic drugs upregulate DRD2 expression in astrocyte cultures [44].…”

Section: Pfc Dopaminergic Afferentsmentioning

confidence: 99%

Astrocyte expression of D2-like dopamine receptors in the prefrontal cortex

Mladinov

Mayer

Brčić

et al. 2010

Translational Neuroscience

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IntroductionThe dopaminergic system subserves many aspects of normal human behavior and is involved in the pathogenesis of a number of psychiatric and neurological conditions, such as schizophrenia, drug abuse, and depression Astrocyte expressIon of D2-lIke DopAmIne receptors In the prefrontAl cortex AbstractThe dopaminergic system is of crucial importance for understanding human behavior and the pathogenesis of many psychiatric and neurological conditions. The majority of studies addressing the localization of dopamine receptors (DR) examined the expression of DR in neurons, while its expression, precise anatomical localization and possible function in glial cells have been largely neglected. Here we examined the expression of D2-like family of DR in neuronal and glial cells in the normal human brain using immunocytochemistry and immunofluorescence. Tissue samples from the right orbitomedial (Brodmann's areas 11/12), dorsolateral (areas 9/46) and dorsal medial (area 9) prefrontal cortex were taken during autopsy from six subjects with no history of neurological or psychiatric disorders, formalin-fixed, and embedded in paraffin. The sections were stained using novel anti-DRD2, anti-DRD3, and anti-DRD4 monoclonal antibodies. Adjacent sections were labeled with an anti-GFAP (astroglial marker) and an anti-CD68 antibody (macrophage/microglial marker). The pyramidal and non-pyramidal cells of all three regions analyzed had strong expression of DRD2 and DRD4, whereas DRD3 were very weakly expressed. DRD2 were more strongly expressed in layer III compared to layer V pyramidal neurons. In contrast, DRD4 receptors had a stronger expression in layer V neurons. The most conspicuous finding was the strong expression of DRD2, but not DRD3 or DRD4, receptors in the white matter fibrous astrocytes and in layer I protoplasmic astrocytes. Weak DRD2-immunoreactivity was also observed in protoplasmic astrocytes in layers III and V. These results suggest that DR-expressing astrocytes directly participate in dopaminergic transmission of the human prefrontal cortex.

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“…ACM is known to contain a number of factors such as transforming growth factor-␤ (TGF-␤) (Tran et al, 1999), S100␤ (Eriksen and Druse, 2001), fibroblast growth factor-2 (Reuss and Unsicker, 2000), plasminogen activator inhibitor-1 (Kimura et al, 2000), and others. Among them, we examined possible involvement of TGF-␤ in ACM-induced HO-1 expression, because TGF-␤ has been shown to induce HO-1 expression in epithelial cells (Hill-Kapturczak et al, 2000).…”

Section: )mentioning

confidence: 99%

Astrocytes Induce Hemeoxygenase-1 Expression in Microglia: A Feasible Mechanism for Preventing Excessive Brain Inflammation

et al. 2006

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Survival and Differentiation of Dopaminergic Mesencephalic Neurons Are Promoted by Dopamine-Mediated Induction of FGF-2 in Striatal Astroglial Cells

Cited by 39 publications

References 54 publications

BDNF‐dependent stimulation of dopamine D₅ receptor expression in developing striatal astrocytes involves PI3‐kinase signaling

BDNF‐dependent stimulation of dopamine D₅ receptor expression in developing striatal astrocytes involves PI3‐kinase signaling

Astrocyte expression of D2-like dopamine receptors in the prefrontal cortex

Astrocytes Induce Hemeoxygenase-1 Expression in Microglia: A Feasible Mechanism for Preventing Excessive Brain Inflammation

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Survival and Differentiation of Dopaminergic Mesencephalic Neurons Are Promoted by Dopamine-Mediated Induction of FGF-2 in Striatal Astroglial Cells

Cited by 39 publications

References 54 publications

BDNF‐dependent stimulation of dopamine D5 receptor expression in developing striatal astrocytes involves PI3‐kinase signaling

BDNF‐dependent stimulation of dopamine D5 receptor expression in developing striatal astrocytes involves PI3‐kinase signaling

Astrocyte expression of D2-like dopamine receptors in the prefrontal cortex

Astrocytes Induce Hemeoxygenase-1 Expression in Microglia: A Feasible Mechanism for Preventing Excessive Brain Inflammation

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BDNF‐dependent stimulation of dopamine D₅ receptor expression in developing striatal astrocytes involves PI3‐kinase signaling

BDNF‐dependent stimulation of dopamine D₅ receptor expression in developing striatal astrocytes involves PI3‐kinase signaling