Survival and prognostic factors of endometrial cancer patients in Iceland 1964–1985: Can attendance at population-based pap-smear screening affect survival?

Sigurðsson, Kristján; Sigurdardottir, Bergthóra; Steinsson, Stefán; Benediktsdóttir, Kristrún R.; Sigurvinsson, Trausti; Sigvaldason, Helgi

doi:10.1002/(sici)1097-0215(19980417)79:2<166::aid-ijc12>3.0.co;2-8

Cited by 10 publications

(6 citation statements)

References 20 publications

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“…Although it seemed strange that patient age was an independent prognostic variable of malignancies, a number of studies have reported age as a significant independent variable of endometrial cancer (9)(10)(11)(12)(13)(14) , as well as of breast cancer (19) , in multivariate analysis. While some studies took an opposing view (15)(16)(17)(18) , others reported good prognoses for patients aged 45 years or younger with endometrial cancer (2)(3)(4) and poor prognoses for those aged 65 years or older (4)(5)(6)(7) .…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have reported that the reasons for a better prognosis for younger patients were the early stage of the disease and a low architectural grade; poorer prognoses for older patients were due to deep myometrial invasion and high grade (2)(3)(4)(5)(6)(7)(8) . While some studies revealed that age was an independent prognostic variable in a multivariate analysis (9)(10)(11)(12)(13)(14) , others reported no association between age and prognosis (15)(16)(17)(18) .…”

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confidence: 99%

“…Although an association of patient age with prognosis in endometrial cancer has been frequently reported (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) , the matter remains controversial. Some studies have stated that the prognosis of patients aged 45 years or younger with endometrial cancer was good (2)(3)(4) , while others have found the prognosis poor for those aged 65 years or older (4)(5)(6)(7) .…”

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confidence: 99%

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Association between menopausal state and prognosis of endometrial cancer

Nakanishi¹,

Ishikawa²,

Suzuki³

et al. 2001

Int J Gynecol Cancer

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The purpose of our study was to examine the menopausal state as an independent prognostic variable of endometrial cancer and determine the conditions under which the menopausal state would be an independent prognostic variable of such cancer. We studied the clinical and pathologic variables of 255 patients with invasive endometrial cancer. In comparisons of the clinicopathologic variables between menopausal states, obesity and deep myometrial invasion were found more frequently in older patients than in younger ones. Multivariate analysis performed on 255 cases with complete pathologic data identified menopausal state, cervical invasion, pelvic lymph node metastasis, and tumor grade as prognostic variables. Univariate analysis revealed that survival of older patients with FIGO pathologic stage Ib disease was significantly poorer than in younger patients, while there was no significant difference in the analyses of stage Ic or advanced disease beyond stage II. We conclude that menopausal state was an independent prognostic variable for patients with early endometrial cancer, but not for patients with advanced disease.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Association between menopausal state and prognosis of endometrial cancer

Nakanishi¹,

Ishikawa²,

Suzuki³

et al. 2001

Int J Gynecol Cancer

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“…In der Literatur werden nach übereinstimmender Auffassung verschiedene Subtypen des Endometriumkarzinoms mit z.T. erheblichen Unterschieden hinsichtlich der Prognose und Überlebenszeit der Patientinnen in Verbindung gebracht (Christopherson et al, 1983(Christopherson et al, , 1982aAlberhasky et al, 1982;Connelly et al, 1982;Sigurdsson et al, 1998;Silverberg et al, 1972;Trope et al, 2001). Diesbezüglich werden die histologischen Tumorentitäten "klarzellig", "adenosquamös", "serös-papillär", "undifferenziert" als primär prognostisch ungünstige Tumortypen klar den histologischen Tumorsubtypen mit guter Prognose (endometrioide Adenokarzinome, Adenoakanthome und sekretorische Karzinome) gegenübergestellt (Christopherson et al, 1983(Christopherson et al, , 1982aAbeler et al, 1992).…”

Section: Lymphangiosis Und Hämangiosis Carcinomatosaunclassified

Prognosefaktoren des Endometriumkarzinoms - Ein Vergleich klinischer und immunhistochemisch bestimmter Parameter

Brohn¹,

Kullmer²,

Knoblauch³

et al. 2004

Geburtshilfe Frauenheilkd

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In den meisten Fällen erfolgt die Diagnose Endometriumkarzinom in einem frühen, doch auch in ca. 20 % in einem fortgeschrittenen Stadium. Welche tumorbiologischen Eigenschaften führen dazu, dass einige Endometriumkarzinome erst in fortgeschrittenen Stadien entdeckt werden? Material und Methodik: Ein Kollektiv von 183 Patientinnen mit Karzinomen des Endometriums wurde reevaluiert im Hinblick auf das klinische Follow-up sowie der Histopathologie (myometrane Tumorinvasionstiefe, Tumortyp, Grading, Lymphangiosis und Hämangiosis carcinomatosa, Tumornekrose). Zusätzlich erfolgten immunhistochemische Färbungen zur Detektion der Expression von Östrogen-und Progesteronrezeptor, Fibronektin und Faktor VII aktivierende Protease (FSAP) unter Verwendung der Streptavidin-Biotin-Methode. Mithilfe der Kaplan-Meier-Überlebenszeitanalyse wurden die prognostischen Parameter analysiert; bivariate Korrelationen sowie einfache und schrittweise Diskriminanzanalyse ermöglichten die Analyse der Relevanz der genannten Faktoren im Hinblick auf die Tumorprogression. Ergebnisse: Tumorstadium (FIGO) und Hämangiosis carcinomatosa konnten als wichtigste Prognosefaktoren des Endometriumkarzinoms identifiziert werden. Hinsichtlich der o. g. Fragestellung wurde die Lymphangiosis carcinomatosa als wichtigster

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“…Ces constatations invitent à proposer une chirurgie de moins en moins agressive pour l'exploration ganglionnaire. Un certain nombre de facteurs de risque d'atteintes ganglionnaires sont bien identifiés tels que la taille de la tumeur, le type histologique (carcinome séreux, à cellules claires, séropapillaire ou carcinosarcome), le grade histologique, l'existence d'emboles lymphovasculaires et l'invasion myométriale profonde [2,4,8]. Malheureusement, ces données sont mal évaluables en pré-et peropératoires et près de 80 % des curages réalisés sont négatifs [7].…”

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Arguments contre le ganglion sentinelle dans le cancer de l’endomètre : les arguments en sa défaveur

Peres

Barranger

2012

Gynécologie Obstétrique & Fertilité

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Survival and prognostic factors of endometrial cancer patients in Iceland 1964–1985: Can attendance at population-based pap-smear screening affect survival?

Cited by 10 publications

References 20 publications

Association between menopausal state and prognosis of endometrial cancer

Association between menopausal state and prognosis of endometrial cancer

Prognosefaktoren des Endometriumkarzinoms - Ein Vergleich klinischer und immunhistochemisch bestimmter Parameter

Arguments contre le ganglion sentinelle dans le cancer de l’endomètre : les arguments en sa défaveur

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