Survival and prognostic factors of salivary gland malignant mixed tumor-not otherwise specified: A population-based analysis

Soffer, Justin M.; Nassif, Samih J.; Plato, Michael; Chisholm, Jaime; O'Leary, Miriam

doi:10.1016/j.amjoto.2021.103135

Cited by 5 publications

(9 citation statements)

References 21 publications

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“…It represents 3–15% of all malignant salivary gland carcinomas [ 51 ], as in our study. The majority of studies report a higher incidence among men [ 33 , 51 , 52 , 53 ]. The range of patients mean age is from 57 to 62.1 years [ 33 , 51 , 52 , 53 , 54 ], which is consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of studies report a higher incidence among men [ 33 , 51 , 52 , 53 ]. The range of patients mean age is from 57 to 62.1 years [ 33 , 51 , 52 , 53 , 54 ], which is consistent with our results. MEC is considered one of the most common salivary gland malignancies [ 11 , 41 , 55 ], however, in this study, MEC represents only 13.7% of all malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…The choice of appropriate treatment has a direct impact on patient prognosis, but it is not the only prognostic factor. Findings indicate clinical factors such as histopathological type and grade of lesion, advanced tumor stage, facial nerve involvement, vascular invasion, lymph node metastasis, and distant metastasis, negatively affect prognosis [ 14 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. In addition, demographic factors such as gender or age are also factors that affect prognosis [ 14 , 26 , 31 , 34 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinico-Epidemiological Analysis of Most Prevalent Parotid Gland Carcinomas in Poland over a 20-Year Period

Žůrek

Jasak

Jaros

et al. 2022

IJERPH

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(1) Background: Malignant tumours of the salivary glands have different clinical and histopathological characteristics. They most commonly involve the parotid gland. Histopathologically, the most common are mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (AdCC), acinic cell carcinoma (AcCC), adenocarcinoma, carcinoma in pleomorphic adenoma (CPA), and squamous cell carcinoma (SCC). (2) Methods: We analysed 2318 patients with malignant parotid gland tumours reported to the National Cancer Registry (NCR) in Poland over 20 years (1999–2018). The demographic characteristics of patients, clinical factors, and overall survival (OS) were analysed. (3) Results: The average age was 61.33 ± 16.1 years. The majority were males (55%) and urban citizens (64%). High percentage of carcinomas was diagnosed in locoregional (33.7%) and systemic (10.4%) stadium. The most prevalent diagnoses were SCC (33.3%) and adenocarcinoma (19.6%). Surgical resection with adjuvant RT (42.1%) was the most common treatment. The OS analysis showed a median survival time of 5.6 years. The most favorable median OS was found in patients with AcCC (18.30 years), the worst for SCC (1.58 years). (4) Conclusion: AcCC has the best prognosis and SCC the worst. Tumour stadium, treatment, and demographic factors affect prognosis. Improvements in diagnosis and re-evaluation of treatment standards are necessary to enhance the outcome of patients with parotid gland cancers in Poland.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinico-Epidemiological Analysis of Most Prevalent Parotid Gland Carcinomas in Poland over a 20-Year Period

Žůrek

Jasak

Jaros

et al. 2022

IJERPH

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“…Thus, PA is often locally recurring, which is the result of non-radical resections [5,6]. Repeated surgeries of PA recurrences may force tumor tissue into the vessels and lead to the distant development of further foci, which is diagnosed as a metastatic form of PA [7].…”

Section: Introduction 1rationalementioning

confidence: 99%

“…The MS is an atypical location of PA; however, as an empty cavity inside the bone it predisposes tumors Surgeries 2022, 3 154 to develop unnoticed. Therefore, the diagnosis of MS PA may occur once the neoplasm is already extensive or has even transformed into carcinoma ex PA [2,7,9].…”

Section: Introduction 1rationalementioning

confidence: 99%

Maxillary Sinus Pleomorphic Adenoma: A Systematic Review

Chęciński¹,

Nowak

2022

Surgeries

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Background: Pleomorphic adenoma (PA), also known as a mixed tumor, is a neoplasm of the glandular tissue. The maxillary sinus (MS) is an atypical location of PA; however, as an empty cavity inside the bone, it predisposes tumors to develop unnoticed. The aim of the following systematic review was to identify and characterize the diagnostics and prognosis of maxillary sinus pleomorphic adenoma (MSPA). Methods: The cases of MSPA that underwent treatment and were observed for possible recurrence were qualified for the review. The medical databases were searched using the following engines: ACM, BASE, Google Scholar and PubMed. The risk of bias was assessed using the JBI Critical Appraisal Tool for Case Reports. The extracted data were tabulated and summarized in a descriptive manner. Results: To the best knowledge of the authors, only seven cases of MSPA were described in the last 20 years. Relapse occurred in three of these cases and malignant transformation occurred in two. The longest recorded time without recurrence was 4 years. The size of the detected MSPA in the largest dimension ranged in various cases from 40 to 60 mm, with an average of 48 mm. Discussion: All but one of the seven included reports showed flaws during the risk of bias assessment. Only in two of seven reported cases was there no reason to suspect that the tumor had penetrated the sinus from the oral or nasal cavity. The MS is disadvantageous as a location as tumors occupying the entire volume of the sinus are often diagnosed. Recurrences and malignant transformations seem to be frequent and often remain undetected for a prolonged period. Other information: This research received no external funding. OSF Registries number: 8KVGM.

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Development and Validation of Nomograms to Predict Risk and Prognosis in Salivary Gland Carcinoma Patient with Distant Metastases

Shi,

Fan,

Long

et al. 2023

Ear Nose Throat J

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Background: Salivary gland carcinoma (SGC) patients with distant metastasis (DM) are rare, and understanding this disease is insufficient. Nomograms can predict the prognostic probability of patients, while few studies have examined diagnostic and prognostic factors in SGC patients with DM. The purpose of this study was to establish and validate the risk and prognostic nomograms of SGC patients with DM. Methods: Based on the SEER database, we analyzed the data of SGC patients between 2004 and 2015. Logistic regression analyses and Cox proportional hazards regression analyses were used to identify risk and prognostic factors for DM in SGC patients. Based on the Akaike information criterion (AIC) value and likelihood ratio test, the best-fitting model was selected to build risk and prognostic nomograms, and the results were evaluated by receiver operating characteristic (ROC) curves, calibration curves, decision curve analysis (DCA), and Kaplan–Meier (K–M) survival curves. ROC curves were also used to compare the nomograms with the American Joint Committee on Cancer (AJCC) staging system. Results: 7418 SGC patients were included in the study, and 307 (4.14%) of them were diagnosed with DM. This study identified that there are variables (age ≥ 80, no-parotid gland primary site, histologic type of mucoepidermoid carcinoma and squamous cell carcinoma, T stage ≥ T2, N staged ≥ N1, histologic grade ≥ III, and tumor size ≥ 41 mm) associated with the occurrence of DM in SGC patients. Therefore, we constructed diagnostic and prognostic nomograms after incorporating these variables. ROC curves illustrated the better predictive efficacy of 2 nomograms over the AJCC staging system. DCA curves, calibration curves, and K-M survival curves showed that 2 nomograms can accurately predict the occurrence and prognosis of DM among SGC patients in training and validation sets. Conclusion: It was shown that the nomograms were highly discriminative in predicting the diagnosis and prognosis of SGC patients with DM, and could identify high-risk patients, thereby providing SGC patients with individualized treatment plans.

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Survival and prognostic factors of salivary gland malignant mixed tumor-not otherwise specified: A population-based analysis

Cited by 5 publications

References 21 publications

Clinico-Epidemiological Analysis of Most Prevalent Parotid Gland Carcinomas in Poland over a 20-Year Period

Clinico-Epidemiological Analysis of Most Prevalent Parotid Gland Carcinomas in Poland over a 20-Year Period

Maxillary Sinus Pleomorphic Adenoma: A Systematic Review

Development and Validation of Nomograms to Predict Risk and Prognosis in Salivary Gland Carcinoma Patient with Distant Metastases

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