Survival and Renal Function in Untreated Hypercalcaemia

Palmér, Mats; Bergström, Reinhold; Åkerström, Göran; Adami, Hans‐Olov; Jakobsson, Sören; Ljunghall, Sverker

doi:10.1016/s0140-6736(87)91906-4

Cited by 178 publications

(36 citation statements)

References 22 publications

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“…et al (5). Mean follow-up time was greater than 10 years in three of these studies (1,6,12), and 8.2 years in one (5). In the remaining it was 3.5 -5.6 years (2 -4), which might not suffice for forming an opinion.…”

Section: Discussionmentioning

confidence: 84%

“…These laboratory tests are easily measured but give only limited clinical information. A tendency towards high cardiovascular morbidity occurring in hyperparathyroidism was noted by Palmér et al (12), and towards illness of various kinds by Corlew Table 2 Serum calcium levels (Ca/s) (mmol/1) of 19 patients before and after surgery for primary hyperparathyroidism, serum calcium decrease after surgery, and values taken thereafter, and at follow-up. The number of excised (exc) parathyroid glands (Pth), and number of parathyroid gland biopsies (b) out of the number macroscopically identified parathyroid glands are shown.…”

Section: Discussionmentioning

confidence: 91%

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Persistent disease after surgery for primary hyperparathyroidism: the long-term outcome

Hedbäck

Odén

2004

European Journal of Endocrinology

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Objective: Nineteen patients with persistent primary hyperparathyroidism were investigated to evaluate their clinical and laboratory status a long time after treatment was ended. The risk of persistent disease and need for extensive surgery for cure, i.e. more than two neck operations, or mediastinal exploration, was also evaluated. Design: The medical records of 896 consecutive patients operated on for primary hyperparathyroidism were scrutinised at follow-up, a mean of 10.3 years after surgery. Data on state of health, medication, bone fractures and other diagnoses were collected by use of a questionnaire. There were 600 patients still alive, among whom 13 had persistent disease and they were compared with 509 patients who were cured and without any suspicion of recurrent disease, according to laboratory examination. Results: Serum calcium and creatinine values had with few exceptions remained stable over the years. In five patients, serum calcium levels were within the normal range at follow-up. Still, all 19 patients were considered hyperparathyroid. They had substantial cardiovascular morbidity, and their state of health was not as good as that of the patients who were surgically cured. After one operation, 5.5% (95% confidence interval (CI) 4.0-7.2%) had persistent disease, and 2.1% after reoperation. Extensive surgery for cure was performed in 2% of the patients (95% CI 1.1 -3.2%). Conclusions: We found that the state of health was significantly better for patients with cured primary hyperparathyroidism than for patients with persistent disease, but serious deterioration of laboratory values was uncommon. The result of the present study supports surgical treatment.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 91%

Persistent disease after surgery for primary hyperparathyroidism: the long-term outcome

Hedbäck

Odén

2004

European Journal of Endocrinology

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“…There is, therefore, an increasing body of opinion that surgery should now be offered in all cases unless contra-indicated on grounds of fitness to prevent complications of the disease. 5,40 There is also evidence that mortality among patients with untreated primary hyperparathyroidism is increased, mainly from cardiovascular disease, 41 although this does appear to be confined to those with the highest calcium concentrations and longest duration of disease and is not affected by parathyroidectomy. It is possible that earlier surgical intervention may reduce the levels of sick leave as well as mortality from this disease.…”

Section: Discussionmentioning

confidence: 99%

Surgical management of primary hyperparathyroidism – results of a national survey

Özbaş¹,

Pain²,

Tang³

et al. 2003

Annals of the Royal College of Surgeons of England

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“…The false negative studies were high a.t 14 \1-.J:i. th th,2 roc1jor:i.ty ( 7) bt? :i.ng associated with parathyroid hyperplasia secondary to chronic rE-,•nal failure.…”

Section: False Negativesmentioning

confidence: 99%