Survival factors in rhino-orbital-cerebral mucormycosis

A Case Report of Rhino-Orbital-Cerebral Mucormycosis

“…[4] Patients with poorly controlled diabetes and ketoacidosis are at high risk of developing rhinocerebral mucormycosis, with systemic acidosis creating an ideal environment for the growth of Rhizopus. However initial presentation of rhinocerebral mucormycosis infection can often appear non-specific making correct diagnosis extremely difficult until the disease has caused significant morbidity, aggressive fungal invasion of the paranasal sinuses, orbit, hard palate and brain [5] . The basis of mucormycosis treatment remains a combination of extensive surgical debridement and amphotericin B for a protracted period of 4-6 weeks [6] .…”

Mucormicose rinocerebral: apresentação de caso com sobrevida e revisão de literatura

“…Pode ocorrer lesão lítica escura na mucosa nasal ou dorso do nariz, celulite orbitária e facial, febre, ptose palpebral, amaurose, oftalmoplegia, anestesia de córnea, terminando em coma e morte 10 .…”

“…Yohia et al 10 revisaram 208 casos de mucormicose rinocerebral entre 1970 e 1993 e encontraram como principais sintomas: febre (44%), úlcera nasal ou necrose (38%), edema periorbital ou facial (34%), diminuição da acuidade visual (30%), oftalmoplegia (29%), sinusite (26%) e cefaléia (25%). Na verdade, com qualquer doente imunodeprimido, principalmente com cetoacidose diabética, com sintomas de rinossinusite sem melhora com tratamento antibiótico convencional, deve-se ter em mente o diagnóstico de mucormicose.…”

Fungal Keratitis – Study at a Tertiary Eye Care Hospital in Hyderabad

“…Fungal keratitis is one of the major causes of the ulcerative and sight-threatening infection of the cornea but its incidence is usually underestimated in the community (Levin et al, 1996;Yohai et al, 1994). Even the trivial trauma of a dust particle falling on the cornea may disrupt the integrity of the corneal epithelium, predisposing to mycotic keratitis.…”