Survival in a Case of Massive Paraquat Ingestion

Respiratory distress, pneumonic changes on chest X-ray, hypoxaemia, oral candidiasis in a homosexual male: not always Pneumocystis carinii pneumonia

“…A number of treatment options are then available, many of which can be initiated in the emergency department. Oral Fuller's earth may be used for gastric decontamination and can be followed by haemodialysis, antioxidant therapy such as acetylcysteine and desferoxamine, vitamin E, colchicine, methylprednisolone, cyclophosphamide, and delayed continuous nitric oxide inhalation [6][7][8]. Some of these treatment options are still experimental.…”

Os riscos e danos nas intoxicações por paraquat em animais domésticos

“…Para a excreção do paraquat absorvido, medidas como a diurese forçada (BEASLEY, 1999;KUWAHARA et al, 1994, LHEUREUX et al, 1995, diálise peritonial (BEASLEY, 1999), hemodiálise, hemoperfusão e plasmaferese (KUWAHARA et al, 1994, LHEUREUX et al, 1995 podem ser adotadas.…”

Toxicology of Herbicides

“…Other therapies that have been investigated include removal of paraquat from the blood by forced diuresis, peritoneal dialysis, haemodialysis, or haemoperfusion using sorbent materials, including charcoal haemoperfusion (Tabei, Asano, and Hosoda, 1982). Corticosteroids have also been tried (Bismuth et al, 1982) as have acetylcysteine and deferoxamine (Lheureux et al, 1995), nitric oxide by inhalation (Eisenman et al, 1998), radiotherapy (Talbot and Barnes, 1988), and lung transplantation. Some measures have at times seemed promising, thus Addo, Ramdial, and Poon-King (1984) reported that treatment with cyclophosphamade, dexamethasone, forced diuresis with frusemide, triamterine, and hydrochlorothiazide 314 TOXICOLOGY OF HERBICIDES enabled the survival of 15=20 patients.…”