Survival in children with perinatally acquired human immunodeficiency virus type 1 infection

Prognostic Significance of Oral Lesions in Children With Perinatally Acquired Human Immunodeficiency Virus Infection

“…This explanation is consistent with the bimodal distribu¬ tion of disease seen in children. [34][35] Because this was a clinical cohort, there was no set age for first visit and no regularly scheduled follow-up visits. Failure to diagnose a lesion until long after it has occurred could bias the analysis toward longer times from birth to lesion and shorter times from lesion to death.…”

Osteomyelitis as a manifestation of perinatal Human Immunodeficiency Virus disease

“…7 Infants with perinatally acquired HIV-1 infection often are asymptomatic, and physical examination usually is normal in the neonatal period. In a prospective cohort study of 200 infants with perinatally acquired HIV-1 infection, the median age of onset of any HIV-1 related symptom or sign was 5.2 months; the probability of remaining asymptomatic was 19% at 1 year and 6.1% at 5 years of age.…”

Public policy and maternal-foetal HIV transmission

“…It has been argued that early diagnosis of HIV infection in the newborn is important in view of the short interval in which to initiate prophylactic or antiviral treatment before progression of disease (Scott et al, 1989). However, routine screening requires a demonstrated value for early detection of HIV infection in infants, including licensed, effective therapy for asymptomatic HIV-infected children who would otherwise not benefit from therapy because of non-detection.…”