1992
DOI: 10.1378/chest.101.3.649
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Survival in COPD Patients with a Daytime PaO2 >60 mm Hg with and without Nocturnal Oxyhemoglobin Desaturation

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Cited by 175 publications
(119 citation statements)
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“…Other resting indices have been found to predict the prognosis of these patients, the most important being BMI [175,176], IC/total lung capacity (TLC) ratio [177], arterial hypoxaemia during sleep [178], pulmonary artery pressure [179], mixed venous partial pressure of oxygen (PO 2 ) [180] and the degree of functional breathlessness [181].…”
Section: Utility Of Exercise Testing In Prognostic Evaluationmentioning
confidence: 99%
“…Other resting indices have been found to predict the prognosis of these patients, the most important being BMI [175,176], IC/total lung capacity (TLC) ratio [177], arterial hypoxaemia during sleep [178], pulmonary artery pressure [179], mixed venous partial pressure of oxygen (PO 2 ) [180] and the degree of functional breathlessness [181].…”
Section: Utility Of Exercise Testing In Prognostic Evaluationmentioning
confidence: 99%
“…24 In OSA patients without intrinsic lung disease, repetitive, transient oxygen desaturation can lead to (generally mild) pulmonary hypertension. 38 Interest in the physiological changes detailed above is also driven by 2 clinical observations: that survival is better for patients without NOD, compared to those with NOD, even if daytime oxygen saturation is similar 39 ; and that COPD patients are reported to die more frequently at night than expected. McNicholas and Fitzgerald reported in 1984 that patients admitted to the hospital with chronic bronchitis or emphysema were more likely to die at night than other admitted hospital patients.…”
Section: Physiological Consequences Of Nocturnal Oxygen Desaturationmentioning
confidence: 99%
“…One study is available in which survival in desaturating and non-desaturating patients is compared [1]. One hundred and sixty-nine patients with COPD and a FEV t of 35% predicted, who were all normoxaemic (daytime PaO 2 > 8.0 kPa [60 mmHg]), were inves tigated.…”
Section: Consequences O F Nocturnal Hypoxaemiamentioning
confidence: 99%
“…As a consequence, extensive morbidity and mortality do occur in these patients due to complications of hypoxaemia such as polycythaemia, pulmonary hypertension, cor pulmonale and cardiac arrhyth mias. In the course of the disease, periods with arterial oxygen desaturations may first occur dur ing R EM sleep [1], due to hypoventilation [2]. Prospective studies estimate that this occurs in 25-100% of the patients with COPD who are normoxaemic during the day, depending on the definition of desaturation and the severity of the disease [1,3,4].…”
Section: Introductionmentioning
confidence: 99%