Survival of Californian women with epithelial ovarian cancer, 1994–1996: a population-based study

O’Malley, Cynthia D.; Cress, Rosemary D.; Campleman, Sharan L.; Leiserowitz, Gary S.

doi:10.1016/j.ygyno.2003.08.010

Cited by 71 publications

(93 citation statements)

References 32 publications

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“…Studies have shown that younger patients had tumours with higher microvascular density which may be associated with an improved response to paclitaxel/ platinum-based chemotherapy (Hartmann et al, 1994;Kosary, 1994;Chan et al, 2004). Our results reflect that of other studies showing that younger age is an independent prognosticator for improved survival (Yancik et al, 1986;Kosary, 1994;Rodriguez et al, 1994;Barnholtz-Sloan et al, 2003;O'Malley et al, 2003). Nevertheless, this current reports is one of the largest population-based studies that has evaluated the demographic and clinico-pathologic prognostic factors associated with the survival of younger women with ovarian cancer using detailed surgical staging and pathologic information.…”

Section: Discussionsupporting

confidence: 85%

“…Nonetheless, several other published studies have specified age as a significant prognostic factor, with older patients faring less well than younger women (Smedley and Sikora, 1985;Swenerton et al, 1985;Yancik et al, 1986;Omura et al, 1991;Gloecker-Ries, 1993;Thigpen et al, 1993;Kosary, 1994;Rodriguez et al, 1994;Lee et al, 1999;Brun et al, 2000;Schildkraut et al, 2000;Barnholtz-Sloan et al, 2003;Chan et al, 2003;O'Malley et al, 2003).…”

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confidence: 99%

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Ovarian cancer in younger vs older women: a population-based analysis

et al. 2006

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To compare the clinico-pathologic prognostic factors and survival of younger vs older women diagnosed with epithelial ovarian cancer. Demographic, clinico-pathologic, treatment, and surgery information were obtained from patients with ovarian cancer from the Surveillance, Epidemiology, and End Results Program from 1988 to 2001 and analysed using Kaplan -Meier estimates. Of 28 165 patients, 400 were o30 years (very young), 11 601 were 30 -60 (young), and 16 164 were 460 (older) years of age. Of the very young, young, and older patients, 261 (65.3%), 4664 (40.2%), and 3643 (22.5%) had stage I -II disease, respectively (Po0.001). Across all stages, very young women had a significant survival advantage over the young and older groups with 5-year disease-specific survival estimates at 78.8% vs 58.8 and 35.3%, respectively (Po0.001). This survival difference between the age groups persists even after adjusting for race, stage, grade, and surgical treatment. Reproductive age (16 -40 years) women with stage I -II epithelial ovarian cancer who received uterine-sparing procedures had similar survivals compared to those who underwent standard surgery (93.3% vs 91.5%, P ¼ 0.26). Younger women with epithelial ovarian cancer have a survival advantage compared to older patients.

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Section: Discussionsupporting

confidence: 85%

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confidence: 99%

Ovarian cancer in younger vs older women: a population-based analysis

et al. 2006

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“…Major prognostic factors in this study were FIGO stage, residual tumor of > 2 cm, age, ascites, and higher tumor grading [7]. Very similar results were reported by O'Malley et al [8] from California. In their retrospective study, where of 1,493 women only 1,051 received surgical treatment, the 5-year survival was as low as in our cohort.…”

Section: Prognostic Factorssupporting

confidence: 84%

Ovarian Cancer Treatment Reality in Northern Rheinland- Pfalz (Germany). Suboptimal Surgical Treatment as a Possible Cause for Inferior Survival

Weide

Arndt²,

Pandorf³

et al. 2007

Oncol Res Treat

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Background: With regard to incidence, ovarian cancer has the highest mortality of all gynecologic cancers. Patients and Methods: The treatment of 139 consecutive patients with epithelial ovarian cancer who were treated in an oncology group practice in Koblenz, Germany between 1995 and 2003 was evaluated retrospectively. Results: The median age of the patients was 61 years (18-84). FIGO stages were distributed as follows: stage I 15.8%, stage II 12.9%, stage III 53.2%, stage IV 16.5%. 49 patients (35.5%) received surgical treatment at a university hospital or a teaching hospital. 89 patients (64.5%) were operated on in a local or district hospital. A macroscopically complete resection was achieved in only 15 patients (10.8%). The residual tumor was <1 cm in 50 patients (36%), >1 cm in 24 patients (17.3%), and >2 cm in 49 patients (35.5%). 93.3% of the patients received postoperative, platinum-based chemotherapy. Median survival since first diagnosis was 42 months (1-346(+)). The 5-year survival rate of the whole cohort was only 28%. Conclusions: Overall survival in epithelial ovarian cancer was significantly inferior in this patient cohort compared to the results of the FIGO report from 2003. One possible cause may be the suboptimal surgical treatment, with 52.8% of the patients having a postoperative residual tumor larger than 1 cm.

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“…In another recent large population-based study, 4 survival following ovarian cancer was poor, with only 33% of women surviving 5 years. Stage was the strongest predictor of survival, and women diagnosed with stage III or IV disease had 5-year survival estimates of 28% and 10%, respectively, similar to figures in other reports.…”

Section: Discussionmentioning

confidence: 96%

Long-term Survival of a Patient With Widespread Metastases From Epithelial Ovarian Carcinoma Receiving Mind-Body Therapies: Case Report and Review of the Literature

Lev-Ari¹,

Maimon

Yaal-Hahoshen

2006

Integr Cancer Ther

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Five-year survival of patients with stage IV epithelial ovarian carcinoma not treated after recurrence is almost nonexistent in oncological literature. The authors report a patient almost 30 years after surgery of the primary epithelial ovarian carcinoma lesion and 15 years after recurrent disease and incomplete chemotherapy who is alive without evidence of disease. She received no conventional oncological therapy during the past 15 years but rather used many types of alternative medicine, predominantly mindbody therapies. The authors review the relevant literature on this subject and describe what they believe to be the first report of long-term survival of such a patient.

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Survival of Californian women with epithelial ovarian cancer, 1994–1996: a population-based study

Cited by 71 publications

References 32 publications

Ovarian cancer in younger vs older women: a population-based analysis

Ovarian cancer in younger vs older women: a population-based analysis

Ovarian Cancer Treatment Reality in Northern Rheinland- Pfalz (Germany). Suboptimal Surgical Treatment as a Possible Cause for Inferior Survival

Long-term Survival of a Patient With Widespread Metastases From Epithelial Ovarian Carcinoma Receiving Mind-Body Therapies: Case Report and Review of the Literature

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