Survival of diced and block cartilage grafts in combination with injectable calcium hydroxylapatite

Abstract

The use of calcium hydroxylapatite in combination with diced cartilage grafts does not have any long-term negative effects on chondrocyte viability.

The Role of Calcium Hydroxylapatite (Radiesse) as a Regenerative Aesthetic Treatment: A Narrative Review

“…Using a 4-point scale (0% = 0 points, >0%-25% = 1 point, >25%-50% = 2 points, >50%-75% = 3 points, >75%-100% = 4 points), the group found that CaHA-treated groups achieved a mean score of 2.42/4 and control groups (with only implanted cartilage) achieved a mean score of 1.92/4. 92 In an investigation of proteoglycan formation in human subjects, González and Goldberg made similar observations; 86 6 months after treatment with CaHA-R, patients had 65% to 839% increases in proteoglycan content, with a mean percent change of 76.27% ( Figure 4D ). This increase in proteoglycan content was hypothesized to play a short-term role in superficial and structural improvements in the skin.…”

“…To this end, 2 studies have evaluated the proteoglycan synthesizing effect of CaHA-R. Erdogmuş et al conducted an in vivo rabbit study investigating the response and survivability after implantation of block cartilage with and without CaHA. 92 Chondrocyte viability and proliferation, collagen content, elastin content, and proteoglycan content were evaluated histologically. In the groups treated with CaHA, viability, proliferation, collagen, and elastin content were elevated, consistent with previous reports.…”

“…Although not considered part of the ECM, angiogenesis is another marker for tissue regeneration because newly formed tissue is typically accompanied by neovascularization. 92 New vessels are critical for supporting regenerating tissue with blood and other circulatory nutrients, as well as for the continued regeneration of new tissue. It is therefore useful to evaluate the angiogenic effect of regenerative fillers as a proxy for new tissue formation.…”

Efficacy of platelet-rich fibrin matrix on viability of diced cartilage grafts in a rabbit model

“…However, Yilmaz et al reported that this surgical intervention prevented the oxygenation of cartilage tissue for at least 48 hours, and this relative hypoxia led to a loss of regeneration potential that is important for the survival of chondrocytes . Erdogmus et al reported that the use of calcium hydroxylapatite in combination with diced cartilage grafts does not have any long‐term negative effects on chondrocyte viability …”

Cartilage Regeneration Units Based on Hydrogel Microcarriers for Injectable Cartilage Regeneration in an Autologous Goat Model

“…After comparing the sampling results of eight weeks in nude mice, the group with the best performance in the nude mouse study was injected into the subcutaneous nasal dorsal region in autologous goats at a volume of 3–4 mL. All the samples were collected 12 weeks after implantation …”