Survival of glioblastoma patients related to presenting symptoms, brain site and treatment variables

Tumor infiltrating immune cells in gliomas and meningiomas

“…In case of CNS tumors, immune responses may also contribute to induce changes in patient symptoms and behavior, depending on tumor localization and the specific types of immune cells and mediators involved. In this regard, it is considered that younger patients presenting with acute signs and symptoms of neurologic disease are investigated earlier, and consequently, referred more promptly for treatment (9). Conversely, patients with organic brain lesions in neurologically silent brain areas might present with milder 7 symptoms and/or isolated psychiatric symptoms such as depression, anxiety disorders, schizophrenia, anorexia nervosa, or cognitive dysfunction (10,11).…”

c-Met expression is associated with time to recurrence in patients with glioblastoma multiforme

“…This is true for both European and US populations, and there is no difference between men and women. 1,2 In addition to the traditional treatments, such as surgery, chemotherapy and radiotherapy, various treatments based on the molecular and genetic characteristics of GBM are under investigation. [3][4][5] There are a number of tumor markers that have important roles in the formation and progression of malignant gliomas.…”

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“…2) Radiotherapy -The role of RT in treating glioblastoma has already been established. 1,2,6,8,12,22 Mineo et al 15 mention radiotherapy as the factor with most influence on the prognosis independently of age, the KPS and the surgical extension. According to Barker et al 1 the radiotherapy has more influence in younger patients.…”