Abstract:Patients treated with 50 to < 60 Gy under a potentially curative therapeutic regimen had a significantly lower survival, compared to patients treated with >/= 60 Gy. In terms of quality assurance, the large proportion of patients treated with radiation doses below the curative range of >/= 60 Gy was unexpected.
“…These data enter into the broad spectrum of results on concurrent RCT [13,15]. Based on all data in the aggregate concurrent RCT provides better results that radiotherapy alone with a median survival of 9 months [1,11]. …”
After including a larger group of patients than in 2003 and following the patients for several years, the authors determine that concurrent RCT consisting of vinorelbine plus a platinum compound and conventional fractionated radiotherapy can be carried out with manageable toxicity, even in this negatively selected population of patients. Their survival rates were comparable to those achieved in other studies with simultaneous RCT.
“…These data enter into the broad spectrum of results on concurrent RCT [13,15]. Based on all data in the aggregate concurrent RCT provides better results that radiotherapy alone with a median survival of 9 months [1,11]. …”
After including a larger group of patients than in 2003 and following the patients for several years, the authors determine that concurrent RCT consisting of vinorelbine plus a platinum compound and conventional fractionated radiotherapy can be carried out with manageable toxicity, even in this negatively selected population of patients. Their survival rates were comparable to those achieved in other studies with simultaneous RCT.
“…In conventional radiotherapy dose escalation has been proved to achieve better tumor control and survival, but it is limited by higher toxicity to the normal tissue [2,4]. For small early-stage peripheral tumors hypofractionated stereotactic radiotherapy has shown an important improvement of clinical results in comparison with 3D-CRT.…”
“…However, due to the side effects, the radiation dose is limited by the volume of the normal tissues. If uncertainties resulting from tumor motions will not be considered when performing PTV delineation, this involves the risk that the CTV cannot be covered as required, and consequently, the delivery of an adequate tumor-destroying dose becomes doubtful [2,4,8].…”
Section: Discussionmentioning
confidence: 99%
“…In the treatment of the disease, surgery, radiotherapy and chemotherapy play an important role [1,4,9,10]. Radiotherapy and chemotherapy are often used as a combined modality, like in a variety of different tumors [5,19,38].…”
Besides the advantage of optimal patient positioning, the movements of the bony chest wall can be considerably reduced by using the immobilization system. However, this fixation system has limitations concerning its suitability for minimizing tumor motions.
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