2022
DOI: 10.1200/jco.2022.40.4_suppl.081
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Survival outcomes associated with chemotherapy-induced neutropenia in the adjuvant treatment of colorectal cancer with FOLFOX.

Abstract: 81 Background: Patients undergoing adjuvant treatment with FOLFOX for colorectal cancer (CRC) are at risk of developing chemotherapy-induced neutropenia (CIN). We assessed survival outcomes in patients who develop CIN in this setting. Methods: We performed a retrospective chart review of patients with CRC treated with FOLFOX at our institution in Canada from 2013 to 2015. The survival follow-up cut-off date was August 2021. Demographic, treatment, and outcome data were collected. CIN was defined as ANC <1.… Show more

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“…There is considerable diversity in the reported rates for various types of cancer and chemotherapy regimens, [8][9][10][11] making it difficult to estimate the individual risk of neutropenia for specific chemotherapy regimens. Several chemotherapy-induced neutropenia predictive models for individual risk prediction were reported; however, most of these models included multiple cancer types and various treatment strategies, which may increase the bias of prediction.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…There is considerable diversity in the reported rates for various types of cancer and chemotherapy regimens, [8][9][10][11] making it difficult to estimate the individual risk of neutropenia for specific chemotherapy regimens. Several chemotherapy-induced neutropenia predictive models for individual risk prediction were reported; however, most of these models included multiple cancer types and various treatment strategies, which may increase the bias of prediction.…”
Section: Discussionmentioning
confidence: 99%
“…[2][3][4] Oxaliplatinand fluoropyrimidine-based chemotherapy is widely used in digestive tract cancer. [5][6][7] The risk of grade 3/4 neutropenia has been reported to range from 6.3% to 58%, [8][9][10][11] making it difficult to estimate the individual risk of neutropenia.…”
Section: Introductionmentioning
confidence: 99%