Survival Rate and Prognostic Factors among Iranian Breast Cancer Patients

Abstract

Background: Survival time is one of the indicators used for evaluation of the quality of care in different types of malignancies, including breast cancer. The present study aimed to estimate the survival rate of breast cancer and its related factors among Iranian patients. Methods: Overall, 3148 cases of breast cancer who referred to the Cancer Research Center in Shahid Beheshti University of Medical Sciences, Tehran, Iran during 1994-2017 participated in this longitudinal study. Survival estimates were calculated using the Kaplan-Meier method and the Bayesian generalized Birnbaum–Saunders model with cure rate from geometric distribution. Clinical, pathological, and biological variables as potential prognostic factors were entered in univariate and multivariate analyses. In order to identify the significant prognostic factors, 95% highest posterior density (HPD) intervals were used. Results: The overall 1, 5, 10, 15, 20 and 25-year survival rate were 95%, 75%, 60%, 47%, 46% and 46%, respectively. A significant relation was observed between survival time and the variables such as age, size of tumor, number of lymph nodes, stage, histological grade, estrogen receptor, progesterone receptor, and lymphovascular invasion. Conclusion: The findings of this study might help the health managers to plan long-term programs considering regional determinants, public education, and screening for early detection of breast cancer cases which can eventually influence the overall survival rate of these patients.

Survival Outcomes of Breast Cancer in Sudanese Women: A Hospital-Based Study

“…The negative association between the clinical stage and survival rates was largely documented by many authors. 34 , 39 , 44 , 47 , 49 , 51 Our findings regarding 5-year OS rates per stage were to some extent comparable to data from developing countries, 34 , 49 but poorer than that from developed countries. 13 , 14 , 16 Interestingly, in our study, women with stage I had poorer survival compared to those with stage II, taking into account the small number—only seven patients—of cases diagnosed with stage I in the current study.…”

“…34 , 42 , 44 , 52 Many authors have documented the relation of OS and histologic grade of tumor. 39 , 44 , 51 , 56 In this study, there was an obvious trend toward better survival for patients with well-differentiated tumors.…”

“…A statistically significant association was found between 5-year OS rate and LN involvement, similar to many studies. 34 , 38 , 44 , 51 , 53…”

“…A link has been demonstrated between OS and age at presentation in several studies. 32 , 35 , 44 , 51 However, data on the association of patient age with BC outcome are controversial on whether age is independent of biologic and clinicopathologic factors.…”

Synthesis, radiolabelling, and biological assessment of folic acid‐conjugated G‐3 99m Tc‐dendrimer as the breast cancer molecular imaging agent

“…It is estimated about 2550 new cases of invasive breast cancer in men in 2018 and a man's lifetime risk of breast cancer is about 1 in 1000 [2, 5–7]. The breast cancer incidence was reported in 7582 cases (23% of total cancers in women) in 2009 in Iranian women [8].…”