Survival Rate of Breast Cancer in Eastern Mediterranean Region Countries: A Systematic Review and Meta-Analysis

Abstract

Background:Breast cancer (BC) is one of the main problems of public health around the world. As a consequence, survival rates are one of the most salient indicators for assessing the quality of cancer control and treatment programs.Objectives:The aim of this study is to evaluate the survival rate of breast cancer in the Eastern Mediterranean region at different periods of time.Methods:Medline/PubMed, ProQuest, Scopus, Embase, Web of Knowledge and Google Scholar databases until February 1, 2018. All observational studies (cross-sectional, case-control, and cohort) referring to the survival of breast cancer were included in the study. The heterogeneity and its value were examined by Cochran test and I2 statistics, respectively. Analysis of subgroups performed was based on geographical area and Human Development Index (HDI), using Stata 12 software.Findings:A total of 58 papers were analyzed. Based on a random effect model, the survival rates of breast cancer in different periods—1, 2, 3, 4, 5 and 10 years—were estimated at 93.9, 85, 79.8, 72.6, 69.2, 62.1 and 55.5 percent, respectively. The highest 10-year survival rate was in Iran (59.2%), and the lowest was observed in Bahrain (45%).Conclusions:Evidence suggests that about half of the patients in this area would die before 10 years survival, which is different from more developed countries. Also, high survival rates are associated with high human development index, which can help health policy-makers to better predict the outcomes of patients.

Epidemiology of women diagnosed with breast cancer in Jordan

“…The 5-year OS in Iran was 0.8%, in Morocco 0.9%, and in Saudi Arabia was 82.6%. 23,24 Whereas the pooled 5-year OS in other studies conducted in 22 countries in the EMR was 0.7% (95% CI: 0.7, 0.7). 23 The variances in OS may highlight disparities and and cultural beliefs in the EMR, such as Jordan, could explain these differences in BC epidemiology amongst various countries.…”

Evaluation of the Relationship Between Expression of Villin and Gelsolin Genes and Axillary Lymph Node Metastasis in Patients with Breast Cancer

“…Breast cancer is generally considered as the most common malignancy among the female population, affecting 1.7 million women worldwide every year ( 1 , 2 ) constituting one-fourth of cancers in women and 15% of all cancer-related deaths ( 3 ). One in 8 women will develop breast cancer during life ( 4 ).…”

“…Breast cancer onset happens10 years earlier in the Iranian female population (24 in 100000) ( 6 , 7 ). Recently, the survival rate of breast cancer patients has significantly increased due to early detection of malignancy and multiple effective treatments including surgical approaches as well as various chemoradiotherapy agents ( 1 , 8 , 9 ). Villin, a 92.5 kDa protein, is a crucial member of actin-binding proteins generally found in the microvilli of brush borders of epithelial linings of different gastrointestinal organs such as stomach, pancreas gland, bile ducts and intestines; as well as corresponding adenocarcinomas ( 10 , 11 ).…”

The prevalence, epidemiology and screening results of breast cancer in women of Guilan province, north of Iran: A cross-sectional study during 2017–2018

“…Delay in the diagnosis and treatment of breast cancer is an important issue that can lead to disease progression and ultimately increase mortality and decrease the survival rate of patients. [9][10][11][12] Breast cancer screening is one of the best strategies to reduce mortality through early diagnosis, control, and treatment of disease that improves the survival and quality of life of patients. [13][14][15] Therefore, due to the lack of a regular training or screening program for early detection of breast cancer in Iran, about 70% of women go to advanced stages of the disease.…”