Survival rate of colorectal cancer in China: A systematic review and meta-analysis

Ren, Wei; Lian, Jie; Wang, Xin; Pang, Xiangyi; Xu, Benjie; Tang, Shuli; Shao, Jiayue; Lu, Haibo

doi:10.3389/fonc.2023.1033154

Cited by 16 publications

(6 citation statements)

References 58 publications

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“…In Sub-Saharan Africa, the rate was 74% [ 51 ], while in Iran it was around 84–85% [ 52 , 53 ]. In Eastern Mediterranean Region Countries it was 88.07% [ 54 ] and in China, it was 79% [ 55 ]. This finding was also consistent with a population-based study conducted in European countries like England, Denmark, Norway, Canada, Sweden, and Australia where the 1-year survival rate of CRC patients was 74.7%, 77.7%, 82.4%, 83.5%, 83.8%, and 84.9% respectively [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Mortality rate and predictors of colorectal cancer patients in Ethiopia: a systematic review and meta-analysis

Aynalem,

Adal,

Ayele

et al. 2024

BMC Cancer

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Introduction The incidence of colorectal cancer (CRC) has been increasing in Sub-Saharan countries, including Ethiopia. However, the real mortality rate for CRC patients in Ethiopia has not been established. Therefore, this systematic review and meta-analysis aimed to determine the overall mortality rate and identify predictors among CRC patients in Ethiopia. Methods PubMed, EMBASE, Web of Science, Scopus, Science Direct, and Google Scholar were searched to identify relevant articles. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were followed. The quality of the included studies was assessed using the Newcastle-Ottawa Scale Critical Appraisal checklist. A random effect model was used to estimate the pooled mortality rate and adjusted hazard ratio (AHR). Publication bias was assessed using funnel plots and Egger’s regression test, while heterogeneity was evaluated through the Cochran Q test and I2 statistics. Results After reviewing 74 articles, only 7 studies met the criteria and were included in the analysis. The analysis revealed that the overall mortality rate among CRC patients in Ethiopia was 40.5% (95% confidence interval [CI]: 32.05, 48.87) while the survival rates at 1 year, 3 years, and 5 years were 82.3% (95% CI: 73.33, 91.31), 48.8% (95% CI: 43.35, 54.32), and 26.6% (95% CI: 21.26, 31.91) respectively. Subgroup analysis indicated that studies conducted after 2017 had higher mortality rates compared to those studied earlier (43.0% vs. 38.2%). Older age (AHR: 1.89, 95% CI: 1.27, 2.82); being married (AHR: 2.53, 95% CI: 1.79, 3.57); having comorbidities (AHR: 1.84, 95% CI: 1.45, 2.35); having high CEA levels (AHR: 2.06, CI: 1.35, 3.13); being in stage II (AHR: 4.13, 95% CI: 1.85, 9.22), III (AHR: 8.62, 95% CI: 3.88, 19.15), and IV (AHR: 8.06, CI: 2.89, 22.49) were the most important predictors. Conclusion In Ethiopia, the mortality rate among individuals diagnosed with CRC is high, with two out of five patients dying from this disease. Age, marital status, CEA level, comorbidities, and cancer stage were identified as predictors of mortality in CRC patients. Therefore, early detection and screening should be prioritized, particularly for older patients, those who are married, have comorbidities, elevated CEA levels, and advanced cancer stages.

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Section: Discussionmentioning

confidence: 99%

Mortality rate and predictors of colorectal cancer patients in Ethiopia: a systematic review and meta-analysis

Aynalem,

Adal,

Ayele

et al. 2024

BMC Cancer

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“… 2 Colorectal, and gastric cancers have the second, and fourth highest mortality rates worldwide, respectively. 2 Studies show that the five-year survival rate is 85% for stage I and 30% for stage IV in colorectal cancer, 3 94.9% for stage I and 8.1% for stage IV in gastric cancer, 4 Colorectal, gastric cancers have poor survival rates at late stages.…”

Section: Introductionmentioning

confidence: 99%

Interventions to Improve Endoscopic Screening Adherence of Cancer in High-Risk Populations: A Scoping Review

Sun,

Tang,

Zou

et al. 2024

PPA

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Background Colorectal, and gastric cancers have the second, and fourth mortality rates worldwide, respectively. Endoscopic screening is a crucial diagnostic tool for colorectal, and gastric cancers. Effective interventions can improve adherence to endoscopic screening in high-risk populations, which is important for cancer prevention and mortality reduction. This study aimed to identify interventions that could improve adherence to endoscopic screening for cancer in high-risk populations. Methods Combination keywords including colorectal cancer, gastric cancer, screening adherence, and interventions were used to search for articles in PubMed, Web of Science, Cochrane Library, and MEDLINE Complete. The review methodology was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-SCR). Results A total of 12 articles were included in this review: 9 randomized controlled trials(RCT) and 3 quasi-experimental studies(QEDs). Among the extracted studies, 11 were about colorectal cancer, and 1 was about gastric cancer. Most studies used lecture-based or Information Technology-based health education interventions. Narrative interventions have proven to be novel and effective approaches for promoting adherence to endoscopic screening. Health education interventions included cancer epidemiology, cancer risk factors, warning symptoms, and screening methods. Conclusion All interventions involved were effective in increasing individual knowledge of cancer-related endoscopic screening, willingness to undergo screening, and screening behaviors. These findings provide a reference for designing endoscopy-related cancer screening interventions.

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“…Over the past years, the economic impact and healthcare expenditures linked to CRC have experienced a steady increase. Notably, the cumulative healthcare costs for each CRC patient in China surpass the country's per capita gross domestic product (GDP) for the corresponding year 13 , 14 . Consequently, acquiring a comprehensive comprehension of this matter becomes indispensable.…”

Section: Introductionmentioning

confidence: 99%

Exploring the impact of stage and tumor site on colorectal cancer survival: Bayesian survival modeling

Alinia,

Ahmadi,

Mohammadi

et al. 2024

Sci Rep

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Colorectal cancer is a prevalent malignancy with global significance. This retrospective study aimed to investigate the influence of stage and tumor site on survival outcomes in 284 colorectal cancer patients diagnosed between 2001 and 2017. Patients were categorized into four groups based on tumor site (colon and rectum) and disease stage (early stage and advanced stage). Demographic characteristics, treatment modalities, and survival outcomes were recorded. Bayesian survival modeling was performed using semi-competing risks illness-death models with an accelerated failure time (AFT) approach, utilizing R 4.1 software. Results demonstrated significantly higher time ratios for disease recurrence (TR = 1.712, 95% CI 1.489–2.197), mortality without recurrence (TR = 1.933, 1.480–2.510), and mortality after recurrence (TR = 1.847, 1.147–2.178) in early-stage colon cancer compared to early-stage rectal cancer. Furthermore, patients with advanced-stage rectal cancer exhibited shorter survival times for disease recurrence than patients with early-stage colon cancer. The interaction effect between the disease site and cancer stage was not significant. These findings, derived from the optimal Bayesian log-normal model for terminal and non-terminal events, highlight the importance of early detection and effective management strategies for colon cancer. Early-stage colon cancer demonstrated improved survival rates for disease recurrence, mortality without recurrence, and mortality after recurrence compared to other stages. Early intervention and comprehensive care are crucial to enhance prognosis and minimize adverse events in colon cancer patients.

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Survival rate of colorectal cancer in China: A systematic review and meta-analysis

Cited by 16 publications

References 58 publications

Mortality rate and predictors of colorectal cancer patients in Ethiopia: a systematic review and meta-analysis

Mortality rate and predictors of colorectal cancer patients in Ethiopia: a systematic review and meta-analysis

Interventions to Improve Endoscopic Screening Adherence of Cancer in High-Risk Populations: A Scoping Review

Exploring the impact of stage and tumor site on colorectal cancer survival: Bayesian survival modeling

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