Survival Rate of Extrahepatic Cholangiocarcinoma Patients after Surgical Treatment in Thailand

Pattanathien, Pisit; Khuntikeo, Narong; Promthet, Supannee; Kamsa‐ard, Supot

doi:10.7314/apjcp.2013.14.1.321

Cited by 38 publications

(20 citation statements)

References 24 publications

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“…Previous studies of survival in CCA patients have focused on specific subgroups-such as those at advanced stage (Park et al, 2009), receiving surgical resection (Murakami et al, 2011;Pattanathien et al, 2013;Sriputtha et al, 2013) or adjuvant therapy (Knüppel et al, 2012), or specific tumour locations (Cheng et al, 2007;Hasegawa et al, 2007;Nakagohri et al, 2008;Guglielmi et al, 2009;Bunsiripaiboon et al, 2010;Cho et al, 2010;Nuzzo et al, 2010;Li et al, 2011). In addition, most studies were retrospective, only one prospective study (Mihalache et al, 2010) has been reported, and there are none from Asian countries.…”

Section: Introductionmentioning

confidence: 99%

Factors Affecting Survival Time of Cholangiocarcinoma Patients: A Prospective Study in Northeast Thailand

Woradet¹,

Promthet²,

Songserm³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Introductionmentioning

confidence: 99%

Factors Affecting Survival Time of Cholangiocarcinoma Patients: A Prospective Study in Northeast Thailand

Woradet¹,

Promthet²,

Songserm³

et al. 2013

Asian Pacific Journal of Cancer Prevention

Self Cite

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“…The main treatment target should be full excision with R 0 resection (negative surgical margins). A prospective study proves that the 5-year survival rate postsurgical treatment of extrahepatic cholangiocarcinoma is 10.8% [5]. Ghouri et al established that extrahepatic CCA is best healed surgically, the Whipple-resection usually being executed, as in the presented case.…”

Section: Discussionmentioning

confidence: 84%

Over 6-year survival in locally advanced cholangiocarcinoma – a case report

Zugun-Eloae¹,

Ginghină²,

Balan³

et al. 2015

Arch Clin Cases

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Cholangiocarcinoma is a malignancy of the biliary duct system that may originate in the liver and extrahepatic bile duct. Despite aggressive anticancer therapy and interventional supportive care, the overall survival is approximatively 6 months, most patients not being eligible for curative resection.Case description: A 64 year-old patient, diagnosed in 2008 with locally advanced bile duct neoplasm (T3N0M0), who underwent latero-lateral hepatoduodenal anastomosis and cholecystectomy in 2008, followed by neoadjuvant Gemcitabine chemotherapy and cephalic duodenopancreatectomy with tumor exeresis in 2009, uncompliant to follow-up, presents with abdominal meteorism, diffuse abdominal pain, inappetence, weight loss and increased fatigability. Initial ultrasonography showed a localized pancreatic tumor and liquid in the Douglas pouch, both confirmed by CT scan.Discussion: The 6-year survival compared to the general mean survival rate of 17 months, depending on the type of the neoplasm, raises questions about the otherwise histopathology confirmed diagnosis of well differentiated cholangiocarcinoma. The present image documented pancreatic tumor makes the retrospective diagnosis assessment even more intricate. Slow-progressor outlier cases might represent new diagnostic entities, and their understanding can be instrumental in improving the therapeutic efficiency. Long time survival in such diagnostic entities is scarcely reported in literature.

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“…A previous study followed up patients with extrahepatic cholangiocarcinoma following surgical treatment at Srinagarind Hospital, Khon Kaen University, Thailand (Pattanathien et al, 2013). The present study aimed to evaluate the survival rates and factors affecting survival in patients with intrahepatic cholangiocarcinoma following surgical treatment at the same hospital.…”

Section: Survival Rate Of Intrahepatic Cholangiocarcinoma Patients Afmentioning

confidence: 99%

Survival Rate of Intrahepatic Cholangiocarcinoma Patients after Surgical Treatment in Thailand

Sriputtha¹,

Khuntikeo²,

Promthet³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Intrahepatic cholangiocarcinoma (ICC), one of the primary liver cancers, is frequent in the northeastern part of Thailand. Surgical resection remains the best method of treatment, but patients suffering from ICC usually present at a late stage of the disease. Studies of survival and prognostic factors after surgery remain rare. The aim here was to evaluate the survival rate and factors affecting the survival of patients with intrahepatic cholangiocarcinoma after surgery. The study used a retrospective cohort design. The subjects were 73 consecutive patients with ICC, who were admitted for surgery to Srinagarind Hospital, Khon Kaen University, during the period 2005-2009. The censoring date was 31 December, 2011, data being evaluated using uni-and multivariate analyses. Postoperative survival analysis was performed by the Kaplan-Meier method, and the Cox proportional hazard model was used to identify independent prognostic factors. The total follow-up time was 99 person-years. The total number of deaths was 59, giving a mortality rate of 59 per 100 person-years. The cumulative 1-, 3-, and 5-year survival rates were 52.1%, 21.7%, and 11.2%, respectively. The median duration of survival after resection was 12.4 months. Univariate analysis revealed stage of disease, lymph node metastasis, histological type, histological grade and macroscopic classification to be statistically significant (p-value<0.05) prognostic factors. In the multivariate analysis, only macroscopic classification was statistically significant (p-value<0.05). In conclusion, macroscopic classification was the only independent factor found to be significantly associated with survival following surgical treatment of ICC.

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Survival Rate of Extrahepatic Cholangiocarcinoma Patients after Surgical Treatment in Thailand

Cited by 38 publications

References 24 publications

Factors Affecting Survival Time of Cholangiocarcinoma Patients: A Prospective Study in Northeast Thailand

Factors Affecting Survival Time of Cholangiocarcinoma Patients: A Prospective Study in Northeast Thailand

Over 6-year survival in locally advanced cholangiocarcinoma – a case report

Survival Rate of Intrahepatic Cholangiocarcinoma Patients after Surgical Treatment in Thailand

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