Survival trends in glioblastoma and association with treating facility volume

Aulakh, Sonikpreet; DeDeo, Michelle; Free, Joseph; Rosenfeld, Steven S.; Quiñones‐Hinojosa, Alfredo; Paulus, Aneel; Manna, Alak; Manochakian, Rami; Chanan‐Khan, Asher; Ailawadhi, Sikander

doi:10.1016/j.jocn.2019.04.028

Cited by 15 publications

(14 citation statements)

References 4 publications

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“…It is characterized by high mortality despite surgical intervention, chemotherapy, and radiotherapy. The overall survival rate and 5-year postoperative survival are very low, at 8.1 months and 9.8%, respectively [1,2].…”

Section: Introductionmentioning

confidence: 95%

Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme

et al. 2020

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The expression of desaturases is higher in many types of cancer, and despite their recognized role in oncogenesis, there has been no research on the expression of desaturases in glioblastoma multiforme (GBM). Tumor tissue samples were collected during surgery from 28 patients (16 men and 12 women) diagnosed with GBM. The effect of necrotic conditions and nutritional deficiency (mimicking conditions in the studied tumor zones) was studied in an in vitro culture of human brain (glioblastoma astrocytoma) U-87 MG cells. Analysis of desaturase expression was made by qRT-PCR and the immunohistochemistry method. In the tumor, the expression of stearoyl–coenzyme A desaturase (SCD) and fatty acid desaturases 2 (FADS2) was lower than in the peritumoral area. The expression of other desaturases did not differ in between the distinguished zones. We found no differences in the expression of SCD, fatty acid desaturases 1 (FADS1), or FADS2 between the sexes. Necrotic conditions and nutritional deficiency increased the expression of the studied desaturase in human brain (glioblastoma astrocytoma) U-87 MG cells. The obtained results suggest that (i) biosynthesis of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) in a GBM tumor is less intense than in the peritumoral area; (ii) expressions of SCD, SCD5, FADS1, and FADS2 correlate with each other in the necrotic core, growing tumor area, and peritumoral area; (iii) expressions of desaturases in a GBM tumor do not differ between the sexes; and (iv) nutritional deficiency increases the biosynthesis of MUFA and PUFA in GBM cells.

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Section: Introductionmentioning

confidence: 95%

Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme

et al. 2020

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“…Geographical distribution was based on regions: The East Coast had 45%, the Central region had 38.8%, the Pacific had 10.9%, and the Mountain region had 5.3% of the patients. There have been prior studies in oncology regarding differences in care and outcomes by treating center patient volume 12 . We analyzed this aspect by categorizing center volume as equally proportioned quartiles among all centers.…”

Section: Resultsmentioning

confidence: 99%

“…Described odds ratios (ORs) predicted the likelihood of patients receiving treatment at these facility types. Data collection methods for the NCDB have been described previously 12,13 …”

Section: Methodsmentioning

confidence: 99%

“…Adult patients with a diagnosis of 1 of the 5 histopathologic subtypes of TC identified from the NCDB database from 2004 to 2013 were included. We excluded patients without a specified pathology subtype for the TC diagnosis, those without specification of whether they received treatment at an AC versus a NAC, those with stage 0 disease, and those not having a NCDB class of case 10 to 14 (patients who had a diagnosis at the reporting facility, and all treatment or a decision not to treat was done elsewhere), as has been previously used and reported from the NCDB 12,13 . We performed univariate and multivariate analyses to compare socioeconomic and demographic factors influencing patient distribution across a treatment facility category of an AC versus a NAC.…”

Section: Methodsmentioning

confidence: 99%

“…Data collection methods for the NCDB have been described previously. 12,13 Logistic regression analysis was used to examine the association of these factors with the likelihood of seeking initial care at an AC for overall TC. Log-rank tests were performed to look for a difference in mortality between each of the different groups overall and by the stage of cancer.…”

Section: Methodsmentioning

confidence: 99%

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Initial treatment of patients with thyroid cancer: Outcomes and factors associated with care at academic versus nonacademic cancer centers

Alhumaidi

Manochakian

Cochuyt

et al. 2021

Cancer

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Background Factors associated with receiving initial care for thyroid cancer (TC) at academic centers (ACs) versus nonacademic centers (NACs) and their impact on patient outcomes have not been reported. Methods The National Cancer Database with TC cases from 2004 to 2013 was evaluated for association of type of center for initial care with socioeconomic factors and disease and treatment characteristics, as well as overall survival (OS; all‐cause mortality). Results The patients with TC (n = 200,824) included were predominantly women (74%), non‐Hispanic Whites (85%), and from metro areas (84%). Sixty percent received initial care at a NAC. There were no significant differences between treatment groups by age or gender. Among those treated at an AC, a higher proportion belonged to racial/ethnic minorities (16.5%) versus at a NAC (11.6%). Hormone therapy was used more in an AC versus a NAC (60% vs 47%). Patients with all TC pathologies combined had a lower likelihood of death when they received initial care at an AC (hazard ratio [HR], 0.948; P = .0006). Among individual pathologic subtypes, a lower likelihood of death was noted when initial care was received at an AC for follicular (HR, 0.828, P = .0010) and Hurthle cell cancers (HR, 792; P = .0008), as well as stage II papillary thyroid cancer (HR, 0.828; P = .0026), but not for other histopathologic subtypes. Conclusions Initial care at an AC was associated with lower likelihood of death for patients with TC, especially for those with follicular or Hurthle cell subtypes. Optimal resource use with consideration of patients' socioeconomic and demographic factors is imperative to ensure the most appropriate management of patients with TC in various treatment settings.

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Outcome and characteristics of patients with adult grade 4 diffuse gliomas changing sites of treatment

Forster

Hug

Geissler

et al. 2022

J Cancer Res Clin Oncol

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Purpose With increasing patient self-empowerment and participation in decision making, we hypothesized that patients with adult-type diffuse gliomas, CNS WHO grade 4 who change sites of treatment differ from patients being entirely treated in one neuro-oncological center. Methods Prospectively collected data from all diffuse glioma grade 4 patients who underwent treatment in our neuro-oncological center between 2012 and 2018 were retrospectively examined for differences between patients having initially been diagnosed and/or treated elsewhere (External Group) and patients having entirely been treated in our neuro-oncological center (Internal Group). Additionally, a matched-pair analysis was performed to adjust for possible confounders. Results A total of 616 patients was analyzed. Patients from the External Group (n = 78) were significantly younger, more frequently suffered from IDH-mutant astrocytoma grade 4, had a greater extent of tumor resection, more frequently underwent adjuvant therapy and experienced longer overall survival (all p < 0.001). However, after matching these patients to patients of the Internal Group considering IDH mutations, extent of resection, adjuvant therapy, age and gender, no difference in patients’ overall survival was observed anymore. Conclusion The present study demonstrates that mobile diffuse glioma grade 4 patients stand out from a comprehensive diffuse glioma grade 4 patient cohort due to their favorable prognostic characteristics. However, changing treatment sites did not result in survival benefit over similar patients being entirely taken care of within one neuro-oncological institution. These results underline the importance of treatment and molecular markers in glioma disease for patients’ self-empowerment, including changing treatment sites according to patients’ needs and wishes.

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Survival trends in glioblastoma and association with treating facility volume

Cited by 15 publications

References 4 publications

Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme

Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme

Initial treatment of patients with thyroid cancer: Outcomes and factors associated with care at academic versus nonacademic cancer centers

Outcome and characteristics of patients with adult grade 4 diffuse gliomas changing sites of treatment

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