Survival with Colorectal Cancer in Ulcerative Colitis A Study of 102 Cases

Abstract

For colitis-associated colorectal cancers, as for noncolitic cancers, histologic stage is the most important variable determining postoperative survival. The distribution of stages in our series and the survival rates within each stage did not differ appreciably from the distributions and survival rates reported for noncolitic colorectal cancers.

Does Colorectal Cancer in Ulcerative Colitis Patients Constitute a Risk for Chemotherapy Refractoriness? A Systemic Approach by Detailed Analysis via the Electronic Tumor Base Documentation System

“…Our responses -if systemic chemotherapy was required and CRC was not entirelylocalized-showedCRandSDin3patientseach,suggesting that early detection and surveillance of CRC in UC patients is vital and therapy improvement, e.g. with innovativetherapeuticapproaches,seemsdesired,withtheseresults confirmingprioranalyses [17][18][19].Ourdatamayserveasan initial patient cohort that should be enlarged by subsequent analyses from multiple CRC centers to solve the pending questions whether therapeutic response in UC and CRC is more challenging and whether defined risk factors can be verified and enlarged. Thus, our work may encourage eager CRCexpertstoperformlargeranalysesonCRCwithversus without UC, this being especially of interest in novel CRC treatment scenarios and because previous data (Gyde et al 1944(Gyde et al -1976, Connell et al 1947Connell et al -1992), Sugita et al 1959Sugita et al -1988), Jensenetal.1977Jensenetal.…”

“…[18]for16pa-tientswhoseCRCwasdiagnosedwithsurveillancewas87% comparedwith55%ofthosewhodidnotparticipateinsur-veillance(p=0.024) [18].Lastly,Sugitaetal. [19]observeda 5-yearOSof52%inCRCpatientswithUCandriskfactors suchasadvancedcancerstage,largertumorsizeandinfiltrating or ulcerating configuration, these risks also being witnessedinouranalysis.…”

Relationship between clinical parameters and the colitis-colorectal cancer interval in a cohort of patients with colorectal cancer in inflammatory bowel disease

“…Neoplasia in IBD is often multifocal. Dysplasia is often present at several regions throughout the colon, and up to 27% percent of patients show two or three tumors simultaneously at the time of diagnosis [21,22]. This phenomenon also relates to molecular changes related to neoplasia in IBD.…”

Colorectal carcinoma in indeterminate colitis

“…4) As usual with UC as well, 18,26 all 19 adenocarcinomas in this series were located in areas of active disease. 5) Moreover, just as noted in UC and CD, 22,27,28 CRC in IC was often multiple, with 3 of the patients (20%) presenting with 2 or more synchronous cancers. 6) Regarding the association of CRC with dysplasia, the majority of our cases (67%), like those of UC reported by Connell et al, 29 had either adjacent or distal dysplasia.…”