Survivin, a novel anti-apoptosis inhibitor, expression in uterine cervical cancer and relationship with prognostic factors

Section: Discussioncontrasting

confidence: 65%

Expression of Survivin, CD117, and C-erbB-2 in Neuroendocrine Carcinoma of the Uterine Cervix

Sukpan¹,

Settakorn²,

Khunamornpong

et al. 2011

“…In addition to clinical pathologic predictors, some molecular variables were also reported to be correlated with prognosis in cervical carcinoma, such as CD44v6, survivin, VEGF, EGFR, COX‐2, EphA2, and EphrinA‐1. CD44v6 expression was found to be associated with lymphvascular space invasion, deep stromal invasion (23) ; significant survivin expression was noted in cancer patients with lesion size, lymphvascular invasion, and elevated SCC antigen levels (24) ; cytosol VEGF might be a marker for the status of pelvic lymph nodes in early‐stage cervical carcinoma and an independent prognostic indicator of its outcome (25) . EGFR and COX‐2 might predict the poor survival of patients with SCC, and the increased COX‐2 expression in tumor cells was correlated with a shorter interval to tumor recurrence (26) ; the overexpression of EhpA2 and EphrinA‐1 was also a strong predictor of overall survival (27) .…”

Section: Discussionmentioning

confidence: 99%

Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors

Liu

Chen

et al. 2007

Hairy and Enhancer-of-split homologues 1 and 5 (Hes1 and Hes5) are the basic helix-loop-helix transcriptional factors that negatively regulate the cell differentiation during embryogenesis. It has been reported that they may be involved in carcinogenesis in some tumors. The roles of Hes1 and Hes5 in development and progression of cervical carcinoma are not well documented todate. In the study, the expression of Hes1 and Hes5 were detected by immunohistochemistry in 295 cases with various degrees of cervical epithelial lesions, including 78 normal cervical epithelia, 31 mild dysplasia (CIN I), 77 moderate-severe dysplasia (CIN II-III), and 109 squamous cervical carcinomas (SCCs), and their association with various clinical pathologic prognostic variables were analyzed in 73 early-stage SCC patients who underwent surgery. Hes1 and Hes5 expression were found to be significantly higher in SCC compared with CIN as well as higher in CIN than normal cervical epithelia, and positively correlated with various prognostic factors in early-stage cervical carcinoma. Our findings suggest that Hes1 and Hes5 may be involved in carcinogenesis of the cervix and progression of cervical carcinoma. Hes1 and Hes5 overexpression are probably variables to predict poor prognosis of the patients with early-stage cervical carcinoma.

“…In our study, gene expression levels of survivin and survivin‐ΔEx3 in malignant cervical samples were statistically higher than those in normal cervical templates. Lee et al (14) reported on the basis of immunohistochemical evidence that survivin was significantly higher expressed in cervical carcinoma groups compared to the normal control group ( P < 0.05) and that survivin could represent a possible new prognostic marker for uterine cervical carcinoma. Espinosa et al (16) demonstrated that gene expression levels of survivin and survivin‐ΔEx3 were upregulated in cervical carcinomas using semiquantitative RT‐PCR.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, gene expression levels of survivin and survivin-ÁEx3 in malignant cervical samples were statistically higher than those in normal cervical templates. Lee et al (14) reported on the basis of (16) demonstrated that gene expression levels of survivin and survivin-ÁEx3 were upregulated in cervical carcinomas using semiquantitative RT-PCR. Moreover, it has been shown that survivin expression increases during cervical carcinogenesis, following a gradient from low-grade squamous intraepithelial lesions to high-grade squamous epithelial lesions (15) .…”

Section: Discussionmentioning

confidence: 99%

Transcriptional expression of survivin and its splice variants in cervical carcinomas

Futakuchi

Ueda

Kanda

et al. 2007

The objective of this study was to evaluate transcriptional expression of survivin and the two splice variants (survivin-2B and survivin-DeltaEx3) in cervical carcinomas. The gene expression levels of survivin and its splice variants in 11 human cervical carcinoma cell lines and 20 malignant and 12 normal cervical tissue samples were analyzed using quantitative reverse transcription-polymerase chain reaction analysis. Gene expression levels of survivin and survivin-DeltaEx3 in cell lines were higher than those in normal cervical tissues (P= 0.0193 and 0.0489). Transcript levels of survivin and survivin-DeltaEx3 in carcinoma tissues were also higher than those in normal controls (P= 0.0016 and 0.0011). Gene expression levels of survivin and survivin-DeltaEx3 in adenocarcinomas were statistically higher than those in squamous cell carcinomas (P= 0.0260 and 0.0487). There was no significant difference in survivin-2B gene expression between malignant and normal cervical samples or different histologic types. The ratios of survivin-2B/survivin and survivin-DeltaEx3/survivin in carcinoma tissues were higher than those in normal controls (P= 0.0288 and 0.0081). Interestingly, the ratio of survivin-2B/survivin was increased in the patients with higher stages and with pelvic lymph node metastasis (P= 0.0205 and 0.0437), respectively. We conclude that survivin and its splice variants might be involved in the pathogenesis and development of cervical carcinomas.