Survivin Measurement improves Clinical Prediction of Transition From Arthralgia to RA—Biomarkers to Improve Clinical Sensitivity of Transition From Arthralgia to RA

Erlandsson, Malin C.; Turkkila, Minna; Pullerits, Rille; Bokarewa, Maria

doi:10.3389/fmed.2018.00219

Cited by 10 publications

(10 citation statements)

References 56 publications

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“…In the current study, we demonstrate that the concentration of survivin is notably increased in the sera of children with JIA compared to healthy controls, what is in line with the previous observations in adults with RA and children with JIA [ 8 , 16 – 20 ]. Additionally, we show that gender, age, and different JIA onset types did not influence significantly survivin concentration in the serum, as well as in joint fluid.…”

Section: Discussionsupporting

confidence: 93%

Concentration of survivin in children with oligo- and polyarticular juvenile idiopathic arthritis (JIA): diagnostic and prognostic value—a single-center study

et al. 2021

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Aim The goal of the study was to assess the diagnostic and prognostic utility of survivin in patients with juvenile idiopathic arthritis (JIA). Methods Seventy children with JIA—59 newly diagnosed and 11 biologically treated (46 girls and 17 boys) aged 1.5–18 years and 29 healthy children as a control group, appropriately matched in terms of sex and age, were included in the study. The disease activity was established on the basis of the JADAS-27 criteria. The concentration of survivin was assessed by an ELISA test in serum and also 18 matched synovial fluid samples collected from patients with JIA. Results Children with JIA were divided according to the subtype of the JIA. In 65.7% of patients, oligoarthritis was diagnosed. The largest group comprised children of low disease activity (62.9%) according to JADAS-27. The serum concentration of survivin was significantly higher in children with JIA compared to the controls (p < 0.001). The concentration of survivin was higher among patients positive for anti-cyclic citrullinated peptide autoantibodies (ACPA) (p = 0.001). In all synovial fluid samples, the concentration of survivin was higher than in matched serum (p = 0.003). Serum survivin concentration was not significantly associated with radiological damage status or active synovitis assessed by joint ultrasonography. Survivin level was not significantly associated with disease duration time or treatment with TNF-α inhibitors in DMARD’s non-responders. Conclusions Survivin should be considered as a biomarker of joint inflammation helpful in the diagnosis of oligo- and polyarticular JIA and probably not dependent on treatment with TNF-α inhibitors.

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Section: Discussionsupporting

confidence: 93%

Concentration of survivin in children with oligo- and polyarticular juvenile idiopathic arthritis (JIA): diagnostic and prognostic value—a single-center study

et al. 2021

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“…Thus, we con rm the ability of survivin to distinguish children with JIA with sensitivity of 0.843 and of speci city 0.931. The numbers are similar to that obtained by other researchers [8,16]. However, two (6.9%) children from our control group were survivin positive, but their serum survivin concentration was just at the cut-off value (both exactly: 17.37 pg/ml).…”

Section: Discussionsupporting

confidence: 91%

“…Surprisingly, we do not nd signi cant prior association between high survivin level and high disease activity found in adults with RA and in children with JIA [8,11,16,17,19]. Almost 63% of our study group consisted of children with oligoarticular JIA, mostly with low disease activity and short duration time of JIA symptoms.…”

Section: Discussionmentioning

confidence: 56%

Concentration of survivin in children with oligo- and poly-articular juvenile idiopathic arthritis (jia): diagnostic and prognostic value – single center study.

Lipińska

Kaszkowiak

Małachowska

et al. 2020

Preprint

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BACKGROUND: The goal of the study was to assess the diagnostic and prognostic value of survivin in Juvenile Idiopathic Arthritis (JIA).METHODS: Seventy children with JIA – 59 newly diagnosed and 11 biologically treated (46 girls and 17 boys) aged 1.5-18 years and 29 healthy children as a control group, appropriately matched in terms of sex and age, were included into the study. The disease activity was established on the basis of JADAS-27 criteria. Concentration of survivin was assessed by an ELISA test in serum and also 18 matched synovial fluid samples collected from patients with JIA.RESULTS: Children with JIA were divided according to the subtype of the JIA. In 65.7% of patients oligoarthritis was diagnosed. The largest group comprised children of low disease activity (62.9%) according to JADAS-27. The serum concentration of survivin was significantly higher in children with JIA compared to the controls (p<0.001). Concentration of survivin was higher among patients positive for anti-cyclic citrullinated peptide autoantibodies (ACPA) (p=0.001). In all synovial fluid samples the concentration of survivin was higher than in matched serum (p=0.003). Serum survivin concentration was not significantly associated with radiological damage status or active synovitis assessed by joint ultrasonography. Survivin level was not significantly associated with disease duration time or treatment with TNF-α inhibitors in DMARD’s non-responders. CONCLUSIONS: Survivin could be an independent biomarker helpful in the diagnosis of JIA. Survivin measurement should be considered as an aiding tool identifying DMARD’s non-responders.

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“…Thus, we confirm the ability of survivin to distinguish children with JIA with sensitivity of 0.843 and of specificity 0.931. The numbers are similar to that obtained by other researchers [8,16]. However, also two (6.9%) children from our control group were survivin positive, but the survivin concentration in their sera was just at the cut-off value (both exactly:17.37 pg/ml).…”

Section: Disscusionsupporting

confidence: 91%

“…Thus, we failed to confirm survivin prognostic potential for the active and destructive course of the rheumatoid process [7,11,[21][22][23]. Surprisingly, we do not support the prior correlation of high survivin level with higher disease activity found in adults with RA and by Galeotti et al in children with JIA [8,11,16,17,19].…”

Section: Disscusioncontrasting

confidence: 72%

Concentration Of Survivin In Children With Juvenile Idiopathic Arthritis (JIA): Diagnostic And Prognostic Value – Single Center Study

Lipińska¹,

Kaszkowiak²,

Świdrowska-Jaros³

et al. 2020

Preprint

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BACKGROUND: The goal of the study was to assess the diagnostic and prognostic value of survivin in Juvenile Idiopathic Arthritis (JIA). METHODS: Seventy children with JIA – 59 newly diagnosed and 11 biologically treated (46 girls and 17 boys) aged 1.5-18 years and 29 healthy children as a control group, appropriately matched in terms of sex and age, were included into the study. Concentration of survivin was assessed by an ELISA test in serum and also 18 matched synovial fluid samples collected from JIA patients. RESULTS: Children with JIA were divided according to the subtype of the JIA. In 65.7% of patients oligoarthritis was diagnosed. The disease activity was established on the basis of JADAS-27 criteria, distinguishing three levels of inflammatory process activity: low, medium and high. The largest group comprised children of low activity (62.9%) of the disease. The serum concentration of survivin was significantly higher in JIA compared to the controls (p<0.001). Higher concentration of survivin correlated positively with the presence of anti-cyclic citrullinated peptide autoantibodies (ACPA) (p=0.001). In all synovial fluid samples the concentration of survivin was higher than in matched serum (p=0.003). Serum survivin concentration did not statistically significantly change according to radiological damage status or active synovitis assessed by joint ultrasonography. Survivin level was independent of the disease duration time and treatment with TNF-α inhibitors in DMARD’s non-responders. CONCLUSIONS: On the basis of the conducted study, it could be concluded that survivin seem to be an independent biomarker that may be helpful in the diagnosis of JIA. Nevertheless, the higher concentration of survivin is being associated with ACPA positivity, survivin can act as a unique biomarker that identifies an additional group of patients with JIA negative for autoantibodies, even in the early stage of the disease. We have failed to confirm survivin prognostic potential for the active and destructive course of the rheumatoid process, however it is worth to underline that children have better potential for bone regeneration than adults. Survivin measurement should be considered as aiding tool identifying DMARD’s non-responders.

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Survivin Measurement improves Clinical Prediction of Transition From Arthralgia to RA—Biomarkers to Improve Clinical Sensitivity of Transition From Arthralgia to RA

Cited by 10 publications

References 56 publications

Concentration of survivin in children with oligo- and polyarticular juvenile idiopathic arthritis (JIA): diagnostic and prognostic value—a single-center study

Concentration of survivin in children with oligo- and polyarticular juvenile idiopathic arthritis (JIA): diagnostic and prognostic value—a single-center study

Concentration of survivin in children with oligo- and poly-articular juvenile idiopathic arthritis (jia): diagnostic and prognostic value – single center study.

Concentration Of Survivin In Children With Juvenile Idiopathic Arthritis (JIA): Diagnostic And Prognostic Value – Single Center Study

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