Survivors of neuroblastoma and ganglioneuroma and their families.

Bundey, Sarah; Evans, Kathleen

doi:10.1136/jmg.19.1.16

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Complications Of Pregnancy2

Familial Neuroblastoma and Genetic Models Of Neuroblastoma F1

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1986

1999

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Cited by 14 publications

(4 citation statements)

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“…It has been estimated that the risk to siblings and offspring of neuroblastoma cases is <6% (34) and that the heritable fraction of this cancer is <1% (3). The absence of neuroblastoma in the offspring of cases also supports these estimations [35][36][37].…”

Section: Familial Neuroblastoma and Genetic Models Of Neuroblastoma Fsupporting

confidence: 57%

Excess of congenital abnormalities in French-Canadian children with neuroblastoma: A case series study from Montreal

Foulkes

Buu

Filiatrault

et al. 1997

Med. Pediatr. Oncol.

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Section: Familial Neuroblastoma and Genetic Models Of Neuroblastoma Fsupporting

confidence: 57%

Excess of congenital abnormalities in French-Canadian children with neuroblastoma: A case series study from Montreal

Foulkes

Buu

Filiatrault

et al. 1997

Med. Pediatr. Oncol.

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“…The total hereditary fraction of neuroblastoma is probably less than 1%. None of a total of 48 children of apparently sporadic cases developed neuroblastoma in three follow-up series (Li & Jaffe 1974;Bundey & Evans 1982;Hawkins et al, 1989).…”

Section: Resultsmentioning

confidence: 99%

An estimate of the heritable fraction of childhood cancer

Narod

Stiller²,

Lenoir³

1991

Br J Cancer

229

146

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(20). The highest hereditary fractions at individual tumour sites were seen for: retinoblastoma (37.2%); kidney (7.2%); leukaemia (2.6%) and brain and spinal cord (2.0%). When information about family history from published reports was incorporated into the figures calculated from Registry data the total genetic fraction was estimated to be 4.2%. We conclude that there is a clear genetic basis for a small minority of the cancers of childhood, but ethnic variation and the lack of known environmental determinants suggest that the total influence of heredity may be higher.

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“…Several studies have provided information according to survivor sex with respect to prenatal and perinatal morbidity and mortality [3][4][5][6][7][8][9][10][11][12][13][14][15]. These outcomes appear to vary with cancer diagnosis and with specifics of therapy (Tables I, II).…”

Section: Complications Of Pregnancymentioning

confidence: 98%

“…However, the best evidence suggests that offspring of survivors of most diseases [10][11][12][13][14][15] (including the large group with acute lymphoblastic leukemia), when treated with 1970s-1980s therapy do not experience perinatal problems different from those of other babies.…”

Section: Complications Of Pregnancymentioning

confidence: 99%