Susceptibility of Candida albicans and Candida glabrata biofilms to silver nanoparticles in intermediate and mature development phases

Monteiro, Douglas Roberto; Takamiya, Aline Satie; Feresin, Leonardo Perina; Gorup, Luiz Fernando; Camargo, Emerson R.; Delbem, Alberto Carlos Botazzo; Henriques, Mariana; Barbosa, Débora de Barros

doi:10.1016/j.jpor.2014.07.004

Cited by 55 publications

(30 citation statements)

References 30 publications

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“…Antifungal activity against Cladosporium cladosporioides, Aspergillus niger [109], Trichophyton rubrum [104] and Candida sp. [93] has been demonstrated. AgNPs have been found to be a potential weapon against a wide range of viruses.…”

Section: Toxic Effects Of Agnps In Microorganismsmentioning

confidence: 94%

Toxic effects of silver nanoparticles in mammals – does a risk of neurotoxicity exist?

Skalska¹,

Strużyńska²

2015

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A b s t r a c t Over the last decade, silver nanoparticles have become an important class of nanomaterials utilized in the development of new nanotechnologies. Despite the fact that nanosilver is used in many commercial applications, our knowledge about its associated risks is incomplete. Although a number of studies have been undertaken to better understand the impact of silver nanoparticles on the environment, aquatic organisms and cell lines, little is known about their side effects in mammalian organisms. This review summarizes relevant data and the current state of knowledge regarding toxicity of silver nanoparticles in mammals, as well as the accumulated evidence for potent neurotoxic effects. The influence of nanosilver on the central nervous system is significant because of evidence indicating that it accumulates in mammalian brain tissue.

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Section: Toxic Effects Of Agnps In Microorganismsmentioning

confidence: 94%

Toxic effects of silver nanoparticles in mammals – does a risk of neurotoxicity exist?

Skalska¹,

Strużyńska²

2015

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“…More than 70% of these cases are caused by Candida spp, especially in the large population of patients with immune disorders and/or those hospitalized with serious underlying diseases 1, 2 . Candida are the most common fungal pathogens and cause diseases ranging from superficial (oral and vaginal) to systemic (peritonitis, meningitis fungemia) candidiasis 3, 4 .…”

Section: Introductionmentioning

confidence: 99%

Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13

Niemirowicz

Durnaś

Tokajuk

et al. 2017

Sci Rep

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Fungal infections caused by Candida spp. represent an emerging problem during treatment of immunocompromised patients and those hospitalized with serious principal diseases. The ever-growing number of fungal strains exhibiting drug resistance necessitates the development of novel antimicrobial therapies including those based on membrane-permeabilizing agents and nanomaterials as drug carriers. In this study, the fungicidal activities of LL-37 peptide, ceragenin CSA-13 and its magnetic derivatives (MNP@LL-37, MNP@CSA-13) against laboratory and clinical strains of C. albicans, C. glabrata and C. tropicalis were evaluated. These experiments confirm the high anti-fungal activity of these well-characterized agents mediated by their interaction with the fungal membrane and demonstrate elevated activity following immobilization of LL-37 and CSA-13 on the surface of magnetic nanoparticles (MNPs). Furthermore, MNP-based nanosystems are resistant to inhibitory factors present in body fluids and effectively inhibit formation of fungal biofilm. Simultaneously, synthesized nanostructures maintain immunomodulatory properties, described previously for free LL-37 peptide and CSA-13 substrate and they do not interfere with the proliferation and viability of osteoblasts, confirming their high biocompatibility.

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“…Monteiro et al 67 Avaliação da eficácia de um modelo acrílico de poli (etil metacrilato)/tetrahidrofurfuril metacrilato (PEM/THFM) embebido com fluconazol (FLU) ou clorexidina (CHX) na prevenção da formação de biofilme de Candida in vitro. Discos de PEM/ THFM embebidos com CHX (n = 50) ou FLU (n = 50) e discos controle (n = 50) foram incubados com C. Albicans por 2, 7, 14, 21 ou 28 dias a 37 °C.…”

Section: Metodologia Aplicadaunclassified

Novas tendências de combate ao biofilme de Candida em próteses dentárias

et al. 2018

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Susceptibility of Candida albicans and Candida glabrata biofilms to silver nanoparticles in intermediate and mature development phases

Abstract: In general, the intermediate and maturation stages of biofilm development do not interfere in the susceptibility of C. albicans and C. glabrata biofilms to SN. These findings are fundamental for the deployment of new therapies aimed at preventing denture stomatitis.

Cited by 55 publications

References 30 publications

Toxic effects of silver nanoparticles in mammals – does a risk of neurotoxicity exist?

Toxic effects of silver nanoparticles in mammals – does a risk of neurotoxicity exist?

Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13

Novas tendências de combate ao biofilme de Candida em próteses dentárias

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