Susceptibility of Gram-positive and -negative bacteria to novel nitric oxide-releasing nanoparticle technology

Friedman, Adam; Blecher, Karin; Sanchez, David A.; Tuckman-Vernon, Chaim; Gialanella, Philip; Friedman, Joel M.; Martinez, Luis R.; Nosanchuk, Joshua D.

doi:10.4161/viru.2.3.16161

Cited by 122 publications

(106 citation statements)

References 29 publications

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“…Whilst antibiotics and novel derivatives have been the mainstay of empirical therapy, many efforts have been made to design more innovative therapeutic options such as nanosilver, the cytokine interleukin-12, nitric oxide or antistaphylococcal phages [62][63][64][65]. However, the clinical utility of these agents has yet to be demonstrated.…”

Section: New Therapeutic Approachesmentioning

confidence: 99%

Central venous catheter-related biofilm infections: An up-to-date focus on meticillin-resistant Staphylococcus aureus

Esposito

Purrello

Bonnet

et al. 2013

Journal of Global Antimicrobial Resistance

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Section: New Therapeutic Approachesmentioning

confidence: 99%

Central venous catheter-related biofilm infections: An up-to-date focus on meticillin-resistant Staphylococcus aureus

Esposito

Purrello

Bonnet

et al. 2013

Journal of Global Antimicrobial Resistance

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“…The utility of nanoparticles arises from their various physicochemical properties (e.g., hydrophobicity, charge, size), which can be tuned by varying synthetic precursors and procedures. Silica-and gold-based nanoparticles have been developed that release low or high levels of NO [136][137][138][139] and show effectiveness against biofilms [140]. Nanoparticles also offer the advantage that they can be combined with other active molecules, such as antimicrobial agents, e.g.…”

mentioning

confidence: 99%

Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases

Barraud¹,

Kelso²,

Rice

et al. 2014

CPD

221

196

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Studies of the biofilm life cycle can identify novel targets and strategies for improving biofilm control measures. Of particular interest are dispersal events, where a subpopulation of cells is released from the biofilm community to search out and colonize new surfaces. Recently, the simple gas and ubiquitous biological signaling molecule nitric oxide (NO) was identified as a key mediator of biofilm dispersal conserved across microbial species. Here, we review the role and mechanisms of NO mediating dispersal in bacterial biofilms, and its potential for novel therapeutics. In contrast to previous attempts using high dose NO aimed at killing pathogens, the use of low, non-toxic NO signals (picomolar to nanomolar range) to disperse biofilms represents an innovative and highly favourable approach to improve infectious disease treatments. Further, several NO-based technologies have been developed that offer a versatile range of solutions to control biofilms, including: (i) NO-generating compounds with short or long half-lives and safe or inert residues, (ii) novel compounds for the targeted delivery of NO to infectious biofilms during systemic treatments, and (iii) novel NO-releasing materials and surface coatings for the prevention and dispersal of biofilms. Overall the use of low levels of NO exploiting its signaling properties to induce dispersal represents an unprecedented and promising strategy for the control of biofilms in clinical and industrial contexts. AbstractStudies of the biofilm life cycle can identify novel targets and strategies for improving biofilm control measures. Of particular interest are dispersal events, where a subpopulation of cells is released from the biofilm community to search out and colonize new surfaces. Recently, the simple gas and ubiquitous biological signaling molecule nitric oxide (NO) was identified as a key mediator of biofilm dispersal conserved across microbial species. Here, we review the role and mechanisms of NO mediating dispersal in bacterial biofilms, and its potential for novel therapeutics. In contrast to previous attempts using high dose NO aimed at killing pathogens, the use of low, non-toxic NO signals (picomolar to nanomolar range) to disperse biofilms represents an innovative and highly favourable approach to improve infectious disease treatments. Further, several NO-based technologies have been developed that offer a versatile range of solutions to control biofilms, including: (i) NO-generating compounds with short or long half-lives and safe or inert residues, (ii) novel compounds for the targeted delivery of NO to infectious biofilms during systemic treatments, and (iii) novel NO-releasing materials and surface coatings for the prevention and dispersal of biofilms. Overall the use of low levels of NO exploiting its signaling properties to induce dispersal represents an unprecedented and promising strategy for the control of biofilms in clinical and industrial contexts. 3 Increased antimicrobial tolerance in biofilms is the basis for chronic infecti...

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“…The antimicrobial properties of NO may be elicited by direct modification of biomacromolecules or by formation of reactive nitrogen oxide species (RNOS) such as peroxynitrite (OONO − ), S-nitrosothiols (RSNO), nitrogen dioxide (NO 2 ), dinitrogen trioxide (N 2 O 3 ), and dinitrogen tetroxide (N 2 O 4 ). These reactive intermediates exert antimicrobial effects by inducing lipid peroxidation or altering DNA according to Schairer et al [49] RNOS can cause nitrosation of protein thiols and the nitrosylation of metal centres (Fe-S), ultimately modifying the functions of proteins that are essential to cellular processes [50,51].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of methicillin resistant Staphylococcus aureus by a plasma needle

et al. 2014

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Abstract:In numerous recent papers plasma chemistry of non equilibrium plasma sources operating at atmospheric pressure has been linked to plasma medical effects including sterilization. In this paper we present a study of the effectiveness of an atmospheric pressure plasma source, known as plasma needle, in inhibition of the growth of biofilm produced by methicillin resistant Staphylococcus aureus (MRSA). Even at the lowest powers the biofilms formed by inoculi of MRSA of 10 4 and 10 5 CFU have been strongly affected by plasma and growth in biofilms was inhibited. The eradication of the already formed biofilm was not achieved and it is required to go to more effective sources.PACS (2008)

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Susceptibility of Gram-positive and -negative bacteria to novel nitric oxide-releasing nanoparticle technology

Abstract: (2011) Susceptibility of Gram-positive and -negative bacteria to novel nitric oxide-releasing nanoparticle technology, Virulence, 2:3, 217-221,

Cited by 122 publications

References 29 publications

Central venous catheter-related biofilm infections: An up-to-date focus on meticillin-resistant Staphylococcus aureus

Central venous catheter-related biofilm infections: An up-to-date focus on meticillin-resistant Staphylococcus aureus

Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases

Inhibition of methicillin resistant Staphylococcus aureus by a plasma needle

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