Susceptibility of &lt;i&gt;Bacteroides melaninogenicus&lt;/i&gt; to 45 Antibiotics

The activity of moxalactam, cefoxitin, cephalothin, cefamandole, chloramphenicol, clindamycin, metronidazole, and ticarcillin was determined against 344 isolates of anaerobic bacteria. The activity of penicillin G was determined as well for 234 isolates not of the Bacteroides fragilis group. Moxalactam was more active than cephalothin and cefamandole and slightly less active than cefoxitin. Metronidazole was the most active antimicrobial agent against the B. fragilis group, whereas chloramphenicol was most active overall. Clostridium species were the most resistant group of organisms tested. Relatively high concentrations of penicillin were required to inhibit the C. perfringens strains: 80% at 0.5 U/ml and 100% at 16 U/ml. Our study demonstrates the need for periodic anaerobe susceptibility testing in order to better guide empiric antibiotic therapy.

mentioning

confidence: 50%

“…Thus, empiric treatment is necessary for the majority of patients with anaerobic infections. In view of the changing susceptibility of anaerobes (2,17) (1, 6, 7). Cefoxitin was most active, inhibiting 90% of B. fragilis, B. distasonis, B. vulgatus, and Bacteroides ovatus at c32 ug/ml.…”

mentioning

confidence: 99%

Susceptibility of anaerobic bacteria to nine antimicrobial agents and demonstration of decreased susceptibility of Clostridium perfringens to penicillin

Marrie¹,

Haldane²,

Swantee³

et al. 1981

“…Differences may relate to other variables particular to a geographic locale, but a portion of this diversity in reported susceptibility data also may be based on different specimen sources and the fact that species or strains from different body sites are more dissimilar in their susceptibilities than previously appreciated. These female genital tract isolates were considerably less susceptible than isolates of which all or most were from the respiratory tract of both normal persons and infected patients (15). Additional species ofBacteroides, including B. capillosus, B. disiens, Bacteroides ruminicola, Bacteroides uniformis, and unidentifiable Bacteroides spp.…”

mentioning

confidence: 90%

“…comprise a heterogeneous group that previously were all called Bacteroides melaninogenicus and include in this text ( Bacteroides asaccharolyticus (9) Bacteroides capillosus (6) Bacteroides disiens (7) Bacteroides ruminicola (4) Bacteroides uniformis (4) Bacteroides spp. (6 (1,11,12,15,19), and a number of investigators have concluded that resistance to penicillin G has increased among the B. melaninogenicus group (1,13,15). Differences may relate to other variables particular to a geographic locale, but a portion of this diversity in reported susceptibility data also may be based on different specimen sources and the fact that species or strains from different body sites are more dissimilar in their susceptibilities than previously appreciated.…”

mentioning

confidence: 99%

Antimicrobial susceptibilities of anaerobic bacteria isolated from female genital tract infections

Hill¹,

Ayers²

1985

Certain species or subspecies of anaerobic bacteria are isolated with higher frequency from female genital tract infections than from other anatomic sites. To gain susceptibility data more specific to the treatment of these infections, nine antimicrobial agents were tested by an agar dilution technique against 230 anaerobic bacteria isolated solely from obstetric and gynecological infections. These genital isolates were, in general, very susceptible to imipenem (most active, inhibiting all gram-negative rods at s1 ,ug/ml), clindamycin (all isolates inhibited at s4 ,ug/ml), metronidazole (all gram-negative rods inhibited at s4 ,ug/ml), and chloramphenicol. Penicillin G had generally low activity against Bacteroides spp., not restricted to just the Bacteroides fragilis group, although it was very active against gram-positive species. Bacteroides bivius, a species uniquely common in female genital infections, was particularly resistant (90% MIC, 64 U/ml). Also, the Bacteroides melaninogenicus isolates were less susceptible than previously reported for isolates not

“…However, a number of recent studies have suggested an increasing.resistance of these organisms to penicillin and to other commonly prescribed antibiotics (1,2,5,6,8,10). Although this has aroused concern among dental clinicians, it cannot be determined from these studies whether BPB present as part of the normal oral microflora show similar patterns of increasing resistance.…”

mentioning

confidence: 99%

Antibiotic Susceptibility of Black-Pigmented Bacteroides Isolates from the Human Oral Cavity

Laatsch

Hohenfeldt

Kos

1982

The minimal inhibitory concentrations of penicillin and six other antibiotics were determined for 66 oral black-pigmented Bacteroides isolates by using the National Committee for Clinical Laboratory Standards proposed standard agar dilution technique. These results plus iodometric determination of β-lactamase activity showed that oral isolates of black-pigmented Bacteroides are remaining relatively susceptible to commonly used antibiotics.