1989
DOI: 10.1007/bf02823685
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Susceptibility of multidrug-resistant isolates ofKlebsiella pneumoniae to silver nitrate

Abstract: Multidrug-resistant (MDR) clinical isolates of Klebsiella pneumoniae were checked for their sensitivity toward silver nitrate by the tube-dilution method. Nearly 75% of MDR strains could be successfully inhibited by 5 mg/L of silver nitrate. A significant correlation was observed between incidence of silver and trimoxazole resistance and silver and kanamycin resistance in these isolates. The genetic linkage of these two properties could not be proved since simultaneous curing and co-transfer studies gave negat… Show more

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Cited by 8 publications
(2 citation statements)
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“…In one of the studies from our laboratory, multidrug-resistant K. pneumoniae was found to be sensitive to very low concentrations (5-10 p.p.m.) of silver nitrate (Kapoor et al, 1989). However, its in vivo application has shown some limitations for using its products in burn treatment (Dunn & Edwards-Jones, 2004).…”
Section: Discussionmentioning
confidence: 99%
“…In one of the studies from our laboratory, multidrug-resistant K. pneumoniae was found to be sensitive to very low concentrations (5-10 p.p.m.) of silver nitrate (Kapoor et al, 1989). However, its in vivo application has shown some limitations for using its products in burn treatment (Dunn & Edwards-Jones, 2004).…”
Section: Discussionmentioning
confidence: 99%
“…It also blocks the electron transport chain, interferes with cell wall synthesis, and influences a number of metabolic pathways and DNA replication and transcription (Pandey et al, 2014;Sondi and Salopek-Sondi, 2004). Moreover, even multidrug-resistant strains have being successfully inhibited by silver compounds (Kapoor et al, 1989;Lara et al, 2010). On the other hand, AuNPs have also been explored as antibacterials (Li et al, 2014), particularly because of the inertness and low toxicity of gold (Connor et al, 2005), the activity being dependent on ligands attached to NPs surface.…”
Section: Introductionmentioning
confidence: 99%