Susceptibility of rapidly growing mycobacteria isolated from Australian cats to ivermectin, moxidectin, ceftiofur and florfenicol

Woerde, Dennis J.; Martín, Patricia A.; Govendir, Merran

doi:10.1177/1098612x14565497

Cited by 9 publications

(8 citation statements)

References 34 publications

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“…There are reports from different parts of the world of mycobacteriosis in cats indicating a prevalence of M. fortuitum as the etiologic agent. Usually, cats present skin infections in the form of non-healing ulcerative pyogranulomatous dermatitis and panniculitis [7][8][9][10][11]. In other animals, such as cattle, M. fortuitum can cause chronic mastitis [12].…”

Section: Introductionmentioning

confidence: 99%

Multidrug-resistant Mycolicibacterium fortuitum infection in a companion cat (Felis silvestris catus) in Brazil

Morgado

Ramos

Pereira³

et al. 2022

Access Microbiology

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Mycolicibacterium fortuitum is a fast-growing bacterium and an opportunistic pathogen implicated in human and animal infections. Here we report the first case and genetic characterization of a strain of M. fortuitum isolated from skin lesions of a companion cat with atypical cutaneous mycobacteriosis in Brazil. In addition, the genome of this strain was sequenced, representing the first genome of this opportunistic pathogen isolated from an animal infection. The in silico and in vitro analysis regarding antibiotic resistance of this strain showed an intrinsic multiresistance antibiotic profile. However, this strain showed sensitivity to amikacin and ciprofloxacin, and the cat was treated long-term with these drugs.

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Section: Introductionmentioning

confidence: 99%

Multidrug-resistant Mycolicibacterium fortuitum infection in a companion cat (Felis silvestris catus) in Brazil

Morgado

Ramos

Pereira³

et al. 2022

Access Microbiology

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“…A few years later,Lim et al (2013) examined the antibacterial effect of four avermectins (doramectin, ivermectin, MOX and selamectin) and found no inhibitory effect on the bacteria Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, Streptomyces lividans, Kocuria rhizophila, and Staphylococcus aureus. However, there was reported evidence that MOX may inhibit the growth of Mycobacterium tuberculosis(Lim et al, 2013)d ulcerans(Omansen et al, 2015) which is desirable, but not of other rapidly growing mycobacteria(Woerde et al, 2015). Our results indicate that MOX is inactive against cultivable soil microorganisms.…”

mentioning

confidence: 53%

“…. Macrocyclic lactones, such as MOX, are considered effective against helminths and may affect insects and arachnids, but they are considered inactive against annelids, bacteria and fungi(Lim et al, 2013;Halley et al, 1989b; Kolmann et al, 2004;Woerde et al, 2015). An early study showed that concentrations of 10 − 8 to 10 − 3 moles of pure ivermectin in growth broth affected the reproduction and development of some lamentous fungi but not others(Kollmann et al, 2004).…”

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confidence: 99%

Does faeces excreted by moxidectin-treated sheep impact coprophagous insects and the activity of soil microbiota in subtropical pastures?

Hentz,

Reyes,

Kaschuk

et al. 2023

Preprint

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Moxidectin (MOX) is used to control helminth parasites in ruminant livestock being released through faeces into the environment. We aimed at evaluating the impact of MOX-contaminated sheep feces on soil coprophagous insects, microbial biomass, and activity. In a field experiment, faeces from MOX-treated rams (subcutaneous dose of 0.2 mg kg-1 body weight) and faeces from non-treated rams were placed on an animal-free pasture, protected or not from rain, for 88 days. Coprophagous insects were captured, identified, and counted, while N mineralization, and C e N contents were monitored. In a controlled experiment, faeces from non-treated animals were amended with MOX concentrations ranging from 75 to 3,000 ng MOX kg-1 faeces, mixed with soil from an animal-free pasture, and incubated for 28 days. Soil microbial biomass, respiration, and culture-microbe counting were determined. Diptera, Hymenoptera, Isoptera, and Coleoptera were equally found in faeces from both MOX-treated and non-treated animals. Faeces from MOX-treated animals had more N and degraded faster than those from non-treated animals. Even the lowest MOX concentration decreased soil microbial biomass, respiration, and N mineralization. Despite not harming coprophagous insects, the addition of MOX to feces from drug-free sheep has a negative impact on soil microbial biomass and activity.

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“…On the other hand, the presence of MOX in the faeces did not affect the CFU of fungi and bacteria in the growth media ( Table 3 ). Macrocyclic lactones, such as MOX, are considered effective against helminths and may affect insects and arachnids, but they are considered inactive against annelids, bacteria, and fungi [ 23 , 25 , 49 , 50 ]. An early study showed that concentrations of 10 −8 to 10 −3 M of pure ivermectin in growth broth affected the reproduction and development of some filamentous fungi but not others [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Does Faeces Excreted by Moxidectin-Treated Sheep Impact Coprophagous Insects and the Activity of Soil Microbiota in Subtropical Pastures?

Gilaverte Hentz,

Reyes Reyes,

Kaschuk

et al. 2024

Scientifica

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Moxidectin (MOX) is used to control helminth parasites in ruminant livestock. It is released through feces and remains in the environment for a long period. This study aimed to evaluate the impact of faeces excreted by moxidectin-treated sheep on soil biodiversity (coprophagous insects, soil microbial biomass, and activity) to establish environment-related guidelines regarding the use of MOX in sheep livestock. The study consisted of two experiments. In the first one, faeces from MOX-treated (subcutaneous dose of 0.2 mg·kg−1 body weight) and nontreated rams were placed on an animal-free pasture field, protected or not against rain, for 88 days. Then, coprophagous insects were captured, identified, and counted, and faeces degradation was evaluated by measuring dry weight and carbon (C) and nitrogen (N) contents over time. Diptera, Hymenoptera, Isoptera, and Coleoptera were equally encountered in faeces from MOX-treated and nontreated animals. Faecal boluses of MOX-treated animals (with higher N content) not protected against rain degraded faster than faecal boluses of nontreated animals (with lower N content). In the second experiment, faeces from nontreated animals were amended with increasing amounts of MOX (75 to 3,000 ng·kg−1 faeces), mixed with soil samples from animal-free pasture (1.9 to 75 ng·kg−1 soil), and incubated in a greenhouse for 28 days. Increasing concentrations of MOX did not prevent the growth of cultivable bacteria, actinobacteria, or fungi in culture media. However, even the lower MOX concentration (1.9 ng·kg−1 soil) abruptly decreased soil microbial biomass, basal respiration, and N mineralization. Thus, the results indicate that faeces excreted from sheep treated with MOX under the experimental conditions of this study are not harmful to the coprophagous insects. However, adding MOX to faeces from drug-free sheep had a negative impact on soil microbial activity and biomass.

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Susceptibility of rapidly growing mycobacteria isolated from Australian cats to ivermectin, moxidectin, ceftiofur and florfenicol

Abstract: All drugs appear to have no efficacy in vitro for the treatment of RGM infections.

Cited by 9 publications

References 34 publications

Multidrug-resistant Mycolicibacterium fortuitum infection in a companion cat (Felis silvestris catus) in Brazil

Multidrug-resistant Mycolicibacterium fortuitum infection in a companion cat (Felis silvestris catus) in Brazil

Does faeces excreted by moxidectin-treated sheep impact coprophagous insects and the activity of soil microbiota in subtropical pastures?

Does Faeces Excreted by Moxidectin-Treated Sheep Impact Coprophagous Insects and the Activity of Soil Microbiota in Subtropical Pastures?

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