Susceptibility of Trypanosoma evansi to human blood and plasma in infected mice

Otto, Mateus Anderson; Silva, Aleksandro S. Da; Gressler, Lucas T.; Farret, Matheus Hilliard; Tavares, Kaio César Simiano; Zanette, Régis A.; Miletti, Luiz Cláudio; Monteiro, Sílvia González

doi:10.1016/j.vetpar.2009.10.020

Cited by 18 publications

(14 citation statements)

References 15 publications

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“…However, recent reports suggest that certain subtypes of non-human-infecting trypanosomes may also be resistant to HTLF (285,365,416). It is plausible that this resistance to HTLF has enabled some human infections with non-human-infecting trypanosomes to occur.…”

Section: Trypanosomamentioning

confidence: 99%

Importance of Nonenteric Protozoan Infections in Immunocompromised People

et al. 2010

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SUMMARY There are many neglected nonenteric protozoa able to cause serious morbidity and mortality in humans, particularly in the developing world. Diseases caused by certain protozoa are often more severe in the presence of HIV. While information regarding neglected tropical diseases caused by trypanosomatids and Plasmodium is abundant, these protozoa are often not a first consideration in Western countries where they are not endemic. As such, diagnostics may not be available in these regions. Due to global travel and immigration, this has become an increasing problem. Inversely, in certain parts of the world (particularly sub-Saharan Africa), the HIV problem is so severe that diseases like microsporidiosis and toxoplasmosis are common. In Western countries, due to the availability of highly active antiretroviral therapy (HAART), these diseases are infrequently encountered. While free-living amoebae are rarely encountered in a clinical setting, when infections do occur, they are often fatal. Rapid diagnosis and treatment are essential to the survival of patients infected with these organisms. This paper reviews information on the diagnosis and treatment of nonenteric protozoal diseases in immunocompromised people, with a focus on patients infected with HIV. The nonenteric microsporidia, some trypanosomatids, Toxoplasma spp., Neospora spp., some free-living amoebae, Plasmodium spp., and Babesia spp. are discussed.

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Section: Trypanosomamentioning

confidence: 99%

Importance of Nonenteric Protozoan Infections in Immunocompromised People

et al. 2010

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“…brucei and T. evansi are both sensitive to treatment with human plasma OTTO et al, 2010). Researchers have used plasma therapy from different hosts to treat trypanosomosis (WECHSLER; KONGSHAVN, 1988;OTTO et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, our research group found that mice infected with T. evansi when treated with human plasma and blood can eliminate the parasite from circulation (OTTO et al, 2010). Given these results, this study aimed to test an alternative protocol with human plasma to control T. evansi infection in mice.…”

Section: Introductionmentioning

confidence: 99%

Trypanocidal activity of human plasma on Trypanosoma evansi in mice

Silva

Duck

Fanfa

et al. 2012

Rev. Bras. Parasitol. Vet.

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This study aimed to test an alternative protocol with human plasma to control Trypanosoma evansi infection in mice. Plasma from an apparently 27-year-old healthy male, blood type A+, was used in the study. A concentration of 100 mg.dL-1 apolipoprotein L1 (APOL1) was detected in the plasma. Forty mice were divided into four groups with 10 animals each. Group A comprised uninfected animals. Mice from groups B, C and D were inoculated with a T. evansi isolate. Group B was used as a positive control. At three days post-infection (DPI), the mice were administered intraperitoneally with human plasma. A single dose of 0.2 mL plasma was given to those in group C. The mice from group D were administered five doses of 0.2 mL plasma with a 24 hours interval between the doses. Group B showed high increasing parasitemia that led to their death within 5 DPI. Both treatments eliminated parasites from the blood and increased the longevity of animals. An efficacy of 50 (group C) and 80% (group D) of human plasma trypanocidal activity was found using PCR. This therapeutic success was likely achieved in the group D due to their higher levels of APOL1 compared with group C.

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“…Recently, a research group found that mice infected with T. evansi when treated with human plasma and blood can eliminate the parasite from circulation [34].…”

Section: Apol1 : a Future Hope For Treatment Of Trypanosoma Evansi Inmentioning

confidence: 99%

“…Trypanosoma brucei and T. evansi are both sensitive to treatment with human plasma [21,34]. Researchers have used plasma therapy from different hosts to treat trypanosomosis [35,36].…”

Section: Apol1 : a Future Hope For Treatment Of Trypanosoma Evansi Inmentioning

confidence: 99%

Is Atypical Human Trypanosomosis an Emering Threat to Human Society? : A Debatable one Health Issue to Public Health Experts and Parasitologists

Parashar¹,

Singla²,

Kaur³

2016

Int J Vet Sci Res

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Trypanosomosis is caused by different species of unicellular eukaryotic haemofl agellate Trypanosoma. Though human infection by animal species of trypanosomes is "not possible" as these species fails to infect humans due to innate immunity of the host due to presence of trypanolytic factor in human serum, however, across the world 20 patients with atypical human trypanosomosis are documented, eight of which are confi rmed between 1974 and 2014 due to improved molecular diagnostic assays. However, the numbers of cases are atypical human trypanosomosis caused by animal trypanosomes might be underestimated. Ten atypical cases of human trypanosomosis have so far been reported form Indian subcontinent. Out of these, nine cases were from India and one from Sri Lanka. Three cases of human T. evansi have been reported from the Indian subcontinent (one from Sri Lanka and two from India) during the last decade. Apart from these three cases, at least six more atypical human cases of trypanosomosis caused by rat trypanosome, T. lewisi have been reported. Two casualties due to non-tsetse transmitted trypanosomosis (NTTT) were also reported from India. High prevalence of these two animal trypanosomes in India is now a matter of concern for public health specialists. These raise it as an alarming situation of emerging new zoonotic disease and debatable one health issue to public health experts and parasitologist. There is a need to investigate disease with modern diagnostics by epidemiological based surveys in the fi eld to know the exact situation of the disease. Veterinarian can play very crucial role in diagnosis and control of disease, also by educate and re-educate people about the transmission, prevention and control of disease.

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Susceptibility of Trypanosoma evansi to human blood and plasma in infected mice

Cited by 18 publications

References 15 publications

Importance of Nonenteric Protozoan Infections in Immunocompromised People

Importance of Nonenteric Protozoan Infections in Immunocompromised People

Trypanocidal activity of human plasma on Trypanosoma evansi in mice

Is Atypical Human Trypanosomosis an Emering Threat to Human Society? : A Debatable one Health Issue to Public Health Experts and Parasitologists

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