1998
DOI: 10.1111/j.1600-0536.1998.tb05658.x
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Susceptibility to skin stinging, non‐immunologic contact urticaria and acute skin irritation; is there a relationship?

Abstract: Adverse skin reactions cover many types of response: toxic, irritant, allergic, urticarial, sensory, etc. The relationships between an individual's tendency to develop different types of skin response are not well-described. We examined whether those who perceive stinging might be more likely to experience urticarial, sensory and irritation reactions in skin. A panel of 86 volunteers was tested with 10% lactic acid in the nasolabial fold to assess their ability to perceive stinging. At the same time, their cap… Show more

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Cited by 70 publications
(56 citation statements)
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“…The use of sodium benzoate as preservative and caffeine as stimulant in soft drink are very common. Sodium benzoate is bacteriostatic and fungistatic under acidic conditions but daily intake can bring adverse effects on skin such as rash, non-immunological contact urticarial, metabolic acidosis, hyperpnoea and asthma (Bronaugh et al, 1982;Coverly et al, 1998;Lahti et al, 1984;Freedman, 1977).…”
Section: Introductionmentioning
confidence: 99%
“…The use of sodium benzoate as preservative and caffeine as stimulant in soft drink are very common. Sodium benzoate is bacteriostatic and fungistatic under acidic conditions but daily intake can bring adverse effects on skin such as rash, non-immunological contact urticarial, metabolic acidosis, hyperpnoea and asthma (Bronaugh et al, 1982;Coverly et al, 1998;Lahti et al, 1984;Freedman, 1977).…”
Section: Introductionmentioning
confidence: 99%
“…Benzoic acid [BA] Benzoic acid is carboxylic acid, it is present naturally either free or bounds benzoic acid esters and can be found in many natural products [10].Benzoic acid is extensively used as preserving agent most suitable for foods, fruit juices, and soft drinks. It is harmful at higher than permitted safety levels [11].In humans, the acute toxicity of benzoic acid is low symptoms appear shortly after exposure and disappear within a fewhours, even at low doses [12].Analytical methods for the determination of benzoic acid include spectrophotometric methods [13], which need extensive extraction procedures and are not very specific; gas chromatographic (GC) methods [14], which are more sensitive and specific but need lengthy sample preparation and derivatization prior to determination using high-performance liquid chromatography(HPLC) [15], which has a high specificity and minimum sample preparation and does not require derivatization. Other methods were used to assay benzoic acid like GC-MAS [16] and GC with on line pyrolytic methylation technique [17].…”
Section: • -------------Equationmentioning
confidence: 99%
“…15 Certain individuals report more intense and frequently adverse dermatologic sensations (a phenomenon known in popular usage as sensitive skin), particularly upon exposure to cosmetics, toiletries, and topical medicaments. 16,17 These "sensitive skin" patients report stinging, itching, burning, and dryness 18 over a wide spectrum of intensities 19 that is sometimes accompanied by erythema, desquamation, papules, wheals, and scaling. Self-reports of skin sensitivity, however, are often not verifiable by clinical signs of irritation, 20 and patients who deny subjective discomfort can sometimes demonstrate strong objective response to a given irritant.…”
Section: Sensitivity Of the Vulvamentioning
confidence: 99%