The construction industry offers employment to about one hundred eighty million people worldwide. The modern economy is based on the evolution and development of the construction industry due to the demand for urbanisation and industrialisation. Despite the significant improvement in the construction industry, this sector is considered risky then challenging; and faces the most vulnerable and hazardous work environment. The launch of Occupational Safety and Health (OSH) of ISO 45001-2018 International Standards is inevitable for construction organisations to provide safety, healthy and preventive environment on construction sites to the labours. OSH in construction is a globally important concern, the same goes for Libya. There are several issues ranging from the lack of attention to OSH from the construction company, plus, the increasing cost and time for safety equipment and maintaining safety culture, thus leading to poor workers' performance. These factors lead to low-quality construction work. Resolving problems of OSH practices requires enhancing the requisite knowledge, skills, attributes, and a wealth of experience to lead and manage projects successfully. A study was carried out for adapting the Organisational OSH Performance Practice in Libya Construction Companies. This paper highlights a quantitative research approach to the adaptation of OSH measurement performance in a construction company. The data was collected from 75 respondents of construction practitioners in Libya using structured questionnaires. The study revealed the factors between the OSH regulation in ISO 45001-2018 and OSH organisational performance, subsequently, the intricacies of the relationship will nurture the development of a valid model and recommendations regarding the success of construction projects in Libya. In conclusion, implementing OSH can better manage and measure construction projects and improve the organisational OSH performance.