Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds

Abstract

Non-healing wounds have placed an enormous stress on both patients and healthcare systems worldwide. Severe complications induced by these wounds can lead to limb amputation or even death and urgently require more effective treatments. Electrospun scaffolds have great potential for improving wound healing treatments by providing controlled drug delivery. Previously, we developed fibrous scaffolds from complex carbohydrate polymers [i.e. chitin-lignin (CL) gels]. However, their application was limited by solubility and undesirable burst drug release. Here, a coaxial electrospinning is applied to encapsulate the CL gels with polycaprolactone (PCL). Presence of a PCL shell layer thus provides longer shelf-life for the CL gels in a wet environment and sustainable drug release. Antibiotics loaded into core–shell fibrous platform effectively inhibit both gram-positive and -negative bacteria without inducting observable cytotoxicity. Therefore, PCL coated CL fibrous gel platforms appear to be good candidates for controlled drug release based wound dressing applications.

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

“…Many biopolymers with a biodegradable nature can perform as described previously such as PCL, chitin, silk fibroin, and PLA [ 183 , 184 , 185 , 186 , 187 ]. However, the use of chitosan for controlled drug delivery has been of great interest in nanomedicine research [ 188 ].…”

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

“…Chitin-amphiphilic ion/quaternary ammonium salt having antibacterial and antipollution effects was also used for wound healing [ 226 ]. Chitin-lignin gels, as an extracellular matrix-like scaffold, were applied as wound dressing material that had a property of sustainable drug release especially antibiotics [ 227 ]. Recently, chitin has been applied as a tissue adhesive.…”

An Additively Manufactured Sample Holder to Measure the Controlled Release of Vancomycin from Collagen Laminates

“…The microbial contamination of a surgical wound leads to surgical site infections (SSIs), which require additional treatment and lead to prolonged recovery times [1,2]. To prevent infections, antibiotics are mostly applied systemically [3]. As this may lead to side effects or drug resistance, the local delivery of antibiotics to the surgical site is advantageous [3].…”

“…To prevent infections, antibiotics are mostly applied systemically [3]. As this may lead to side effects or drug resistance, the local delivery of antibiotics to the surgical site is advantageous [3]. Direct application of antibiotics is effective [4].…”

“…However, since a high antibiotic concentration might be toxic for cells [5], the controlled release of antibiotics is preferable. Different delivery systems for controlled antibiotic release have been described in literature, such as nanobioceramics [6], nanoparticles as scaffolds or injections [7], polycaprolactone coated chitin-lignin gels [3] or gentamicin-collagen implants [8]. To prevent the bacterial infection of surgical wounds, different antibiotics such as gentamicin [9], tetracyclines, vancomycin, and tobramycin can be applied [10].…”