Sustainable electrochemical cross-dehydrogenative coupling of 4-quinolones and diorganyl diselenides

Environmentally Benign Synthesis of Quinoline–Spiroquinazolinones by Iron-Catalyzed Dehydrogenative [4 + 2] Cycloaddition of Secondary/Tertiary Anilines and 4-Methylene-quinazolinones

“…Instead, N -methyl analogues were given. To the best of our knowledge, this is first time to employ secondary anilines for cross-dehydrogenative coupling (CDC) annulation to construct tetrahydroquinoline framework. Herein, we demonstrate our preliminary results.…”

Visible light-promoted transition metal-free direct C3-carbamoylation of 2H-Indazoles

“…Nitrogen heterocycles are the essential structural elements widely ubiquitous in pharmaceutical chemistry, ( Vitaku et al, 2014 ; Bhutani et al, 2021 ; Ma et al, 2021a ), organic chemistry, ( Chen et al, 2021 ; Darroudi et al, 2021 ; Jiang et al, 2021 ; Meng et al, 2021 ; Qu et al, 2021 ; Wang and Wang, 2021 ; Chen and Xuan, 2022 ; Gao et al, 2022 ; Wu et al, 2022 ; Zhang et al, 2022 ), and material chemistry ( Huang and Yu, 2021 ). Among these, 2 H -indazole is one of the most important heterocycles, existing in various drugs and bioactive molecules ( Figure 1 ).…”

Regioselective peri-C–H selenylation of aromatic compounds with weakly coordinating ketone groups

“…This transformation is very challenging, because the strong nucleophilicity of the C3-position of N -methyl quinolin-4(1 H )-one readily leads to the formation of the C3-selenylation product. 10 Most importantly, this protocol is also applicable for the late-stage selenylation of bioactive compounds. Reactions of naphthoquinone derivatives, which is an angiogenesis inhibitor 11 or has antimicrobial activity, 12 proceeded well, and the desired products 6h and 6i were obtained in moderate yields.…”