Sustainable lignin and lignin-derived compounds as potential therapeutic agents for degenerative orthopaedic diseases: A systemic review

Pei, Wenhui; Deng, Junping; Wang, Peng; Wang, Xucai; Zheng, Liming; Zhang, Yangheng; Huang, Caoxing

doi:10.1016/j.ijbiomac.2022.05.152

Cited by 39 publications

(15 citation statements)

References 129 publications

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“…All of these secondary metabolites possess well-known antioxidant properties. Indeed, chlorogenic acids [ 25 ] and lignans [ 26 , 33 , 34 ], thanks to their phenolic moiety, have free radical scavenging and chain-breaking antioxidant activities: they donate hydrogen atoms to free radicals, giving rise to phenoxyl radicals stabilized by resonance, and thereby inhibiting the propagation of radical chain reactions and other biological oxidants. Moreover, they act as secondary antioxidants by binding metal ions (Fe(III) and Cu(II)) able to catalyze oxidative processes.…”

Section: Discussionmentioning

confidence: 99%

Jasminum sambac Cell Extract as Antioxidant Booster against Skin Aging

Ceccacci

Lucia²,

Tortora³

et al. 2022

Antioxidants

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Oxidative stress plays a major role in the skin aging process through the reactive oxygen species production and advanced glycation end products (AGEs) formation. Antioxidant ingredients are therefore needed in the skin care market and the use of molecules coming from plant cell cultures provide a unique opportunity. In this paper, the features of an hydroethanolic extract obtained by Jasminum sambac cells (JasHEx) were explored. The antioxidant and anti-AGE properties were investigated by a multidisciplinary approach combining mass spectrometric and bio-informatic in vitro and ex vivo experiments. JasHEx contains phenolic acid derivatives, lignans and triterpenes and it was found to reduce cytosolic reactive oxygen species production in keratinocytes exposed to exogenous stress. It also showed the ability to reduce AGE formation and to increase the collagen type I production in extracellular matrix. Data demonstrated that JasHEx antioxidant properties were related to its free radical scavenging and metal chelating activities and to the activation of the Nrf2/ARE pathway. This can well explain JasHEx anti-inflammatory activity related to the decrease in NO levels in LPS-stimulated macrophages. Thus, JasHEx can be considered a powerful antioxidant booster against oxidative stress-induced skin aging.

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Section: Discussionmentioning

confidence: 99%

Jasminum sambac Cell Extract as Antioxidant Booster against Skin Aging

Ceccacci

Lucia²,

Tortora³

et al. 2022

Antioxidants

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“…Even though some lignin fractions may still exist in the produced XOS, it is not necessary to remove lignin from the products when it is used as the additive in animal feed. It has been reported that lignin possesses a good antioxidant ability, which is a benefit for the health of the animal by scavenging reactive oxygen species (67)(68)(69)(70).…”

Section: Alkaline Extractionmentioning

confidence: 99%

The preparation technology and application of xylo-oligosaccharide as prebiotics in different fields: A review

Huang

et al. 2022

Front. Nutr.

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Xylo-oligosaccharide (XOS) is a class of functional oligosaccharides that have been demonstrated with prebiotic activity over several decades. XOS has several advantages relative to other oligosaccharide molecules, such as promoting root development as a plant regulator, a sugar supplement for people, and prebiotics to promote intestinal motility utilization health. Now, the preparation and extraction process of XOS is gradually mature, which can maximize the extraction and avoid waste. To fully understand the recent preparation and application of XOS in different areas, we summarized the various technologies for obtaining XOS (including acid hydrolysis, enzymatic hydrolysis, hydrothermal pretreatment, and alkaline extraction) and current applications of XOS, including in animal feed, human food additives, and medicine. It is hoped that this review will serve as an entry point for those looking into the prebiotic field of research, and perhaps begin to dedicate their work toward this exciting classification of bio-based molecules.

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“…However, some of the products and byproducts generated from these processes are extremely underutilized. One example that has attracted a lot of attention recently is lignin [6,7]. Only a small fraction (i.e., 1-2%) of the more than 50 million tons of lignin produced annually, as a by-product of the paper industry during cellulose extraction, is then converted into specialty commercial production [8,9].…”

Section: Introductionmentioning

confidence: 99%

Designing Lignin-Based Biomaterials as Carriers of Bioactive Molecules

2023

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There is a need to develop circular and sustainable economies by utilizing sustainable, green, and renewable resources in high-tech industrial fields especially in the pharmaceutical industry. In the last decade, many derivatives of food and agricultural waste have gained considerable attention due to their abundance, renewability, biocompatibility, environmental amiability, and remarkable biological features. Particularly, lignin, which has been used as a low-grade burning fuel in the past, recently attracted a lot of attention for biomedical applications because of its antioxidant, anti-UV, and antimicrobial properties. Moreover, lignin has abundant phenolic, aliphatic hydroxyl groups, and other chemically reactive sites, making it a desirable biomaterial for drug delivery applications. In this review, we provide an overview of designing different forms of lignin-based biomaterials, including hydrogels, cryogels, electrospun scaffolds, and three-dimensional (3D) printed structures and how they have been used for bioactive compound delivery. We highlight various design criteria and parameters that influence the properties of each type of lignin-based biomaterial and corelate them to various drug delivery applications. In addition, we provide a critical analysis, including the advantages and challenges encountered by each biomaterial fabrication strategy. Finally, we highlight the prospects and future directions associated with the application of lignin-based biomaterials in the pharmaceutical field. We expect that this review will cover the most recent and important developments in this field and serve as a steppingstone for the next generation of pharmaceutical research.

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Sustainable lignin and lignin-derived compounds as potential therapeutic agents for degenerative orthopaedic diseases: A systemic review

Cited by 39 publications

References 129 publications

Jasminum sambac Cell Extract as Antioxidant Booster against Skin Aging

Jasminum sambac Cell Extract as Antioxidant Booster against Skin Aging

The preparation technology and application of xylo-oligosaccharide as prebiotics in different fields: A review

Designing Lignin-Based Biomaterials as Carriers of Bioactive Molecules

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