The employment of tools and techniques for monitoring and supervising the performance of industrial systems has become essential for enterprises that seek to be more competitive in today’s market. The main reason is the need for validating tasks that are executed by systems, such as industrial machines, which are involved in production processes. The early detection of malfunctions and/or improvable system values permits the anticipation to critical issues that may delay or even disallow productivity. Advances on Information and Communication Technologies (ICT)-based technologies allows the collection of data on system runtime. In fact, the data is not only collected but formatted and integrated in computer nodes. Then, the formatted data can be further processed and analyzed. This article focuses on the utilization of standard Key Performance Indicators (KPIs), which are a set of parameters that permit the evaluation of the performance of systems. More precisely, the presented research work demonstrates the implementation and visualization of a set of KPIs defined in the ISO 22400 standard-Automation systems and integration, for manufacturing operations management. The approach is validated within a discrete manufacturing web-based interface that is currently used for monitoring and controlling an assembly line at runtime. The selected ISO 22400 KPIs are described within an ontology, which the description is done according to the data models included in the KPI Markup Language (KPIML), which is an XML implementation developed by the Manufacturing Enterprise Solutions Association (MESA) international organization.