Sustainable synthesis of luminescent CdTe quantum dots coated with modified silica mesoporous nanoparticles: Towards new protein scavengers and smart drug delivery carriers

Oliveira, Elisabete; Santos, Hugo M.; Jorge, Susana; Rodríguez‐González, Benito; Novio, Fernando; Lorenzo, Júlia; Ruiz‐Molina, Daniel; Capelo, José Luís; Lodeiro, Carlos

doi:10.1016/j.dyepig.2018.09.047

Cited by 36 publications

(19 citation statements)

References 56 publications

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“…In this synthesis, TEOS was used as a silica source, CTAB as template and cationic surfactant, ethylene glycol as stabilizer and NaOH as a morphological agent. This approach was based on MCM-41 synthesis (Kresge et al, 1992 ; Oliveira et al, 2018 ), and different amounts of TEOS (250 μL−1mL) were tested in order to find the most stable system. As a control, mesoporous silica nanoparticles (MSNPs) were also obtained but without the silver nanoparticle core.…”

Section: Resultsmentioning

confidence: 99%

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Engineered Nanostructured Materials for Ofloxacin Delivery

et al. 2018

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Antibiotic resistance is emerging as a growing worldwide problem and finding solutions to this issue is becoming a new challenge for scientists. As the development of new drugs slowed down, advances in nanotechnology offer great opportunities, with the possibility of designing new systems for carrying, delivery and administration of drugs already in use. Engineered combinations of the synthetic, broad-spectrum antibiotic ofloxacin, rarely studied in this field, with different types of silver, mesoporous silica-based and Pluronic/silica-based nanoparticles have been explored. The nanocarriers as silver core@silica mesoporous (AgMSNPs) and dye-doped silica nanoparticles functionalized with ofloxacin were synthesized and their antibacterial properties studied against S. aureus and E. coli. The best antibacterial results were obtained for the AgMSNPs nanosystem@ofloxacin for the strain S. aureus ATCC 25923, with MIC and MBC values of 5 and 25 μg/mL, proving the efficacy and synergetic effect of the antibiotic and the Ag core of the nanoparticles.

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Section: Resultsmentioning

confidence: 99%

“…MSNPs were synthesized in aqueous media, using TEOS as silica precursor, according to the following protocol published by E. Oliveira et al ( 2018 ). Briefly, 100 mg of CTAB (CH 3 (CH 2 ) 15 N(Br)(CH 3 ) 3 were dissolved in 10 mL of H 2 O MilliQ, stirred and heated to about 50°C.…”

Section: Methodsmentioning

confidence: 99%

Engineered Nanostructured Materials for Ofloxacin Delivery

et al. 2018

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“…The drug-loaded NPs are mainly composed of carrier materials, therapeutic drugs, and targeted ligands. 187 The carrier materials must have high loading capacity in order to load enough drugs for cancer therapy. For example, mesoporous materials and polymeric micelles are often selected as drug-loaded materials because of their high porosity, which can load a large number of drugs.…”

Section: Tumor Therapymentioning

confidence: 99%

Application of rare earth-doped nanoparticles in biological imaging and tumor treatment

et al. 2020

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Rare earth-doped nanoparticles have been widely used in disease diagnosis, drug delivery, tumor therapy, and bioimaging. Among various bioimaging methods, the fluorescence imaging technology based on the rare earth-doped nanoparticles can visually display the cell activity and lesion evolution in living animals, which is a powerful tool in biological technology and has being widely applied in medical and biological fields. Especially in the band of near infrared (700–1700 nm), the emissions show the characteristics of deep penetration due to low absorption, low photon scattering, and low autofluorescence interference. Furthermore, the rare earth-doped nanoparticles can be endowed with the water solubility, biocompatibility, drug-loading ability, and the targeting ability for different tumors by surface functionalization. This confirms its potential in the cancer diagnosis and treatment. In this review, we summarized the recent progress in the application of rare earth-doped nanoparticles in the field of bioimaging and tumor treatment. The luminescent mechanism, properties, and structure design were also discussed.

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“…The smart carriers system was prepared by luminescent CdTe quantum dots coated with modified mesoporous silica nanoparticles. These particles lead to pore size augmentation, permitting better encapsulation and controlled release, of different active principles studied such as, small molecules (rhodamine B), drugs (doxorubicin), and isolated proteins such as bovine serum albumin, lysozyme, carbonic anhydrase, ovalbumin, α-lactalbumin, hemoglobin, myoglobin and cytochrome C. The luminescent QDs permit the imaging of the nanoparticles during cell internalization, as well as the visualization of selective release of doxorubicin inside the cell (via pH stimuli) [45].…”

Section: Qds As a Drug Carrier Systemmentioning

confidence: 99%

Quantum Dots: Next Generation of Smart Nano-Systems

Jahangir¹,

Gilani

Muheem

et al. 2019

PNT

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Background: The amalgamation of biological sciences with nano stuff has significantly expedited the progress of biological strategies, greatly promoting practical applications in biomedical fields. Objective: With distinct optical attributes (e.g., robust photostability, restricted emission spectra, tunable broad excitation, and high quantum output), fluorescent quantum dots (QDs) have been feasibly functionalized with manageable interfaces and considerably utilized as a new class of optical probe in biological investigations. Method: In this review article, we structured the current advancements in the preparation methods and attributes of QDs. Furthermore, we extend an overview of the outstanding potential of QDs for biomedical research and radical approaches to drug delivery. Conclusion: Notably, the applications of QDs as smart next-generation nanosystems for neuroscience and pharmacokinetic studies have been explained. Moreover, recent interests in the potential toxicity of QDs are also apprised, ranging from cell investigations to animal studies.

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Sustainable synthesis of luminescent CdTe quantum dots coated with modified silica mesoporous nanoparticles: Towards new protein scavengers and smart drug delivery carriers

Abstract: Sustainable synthesis of luminescent CdTe quantum dots coated with modified silica mesoporous nanoparticles: Towards new protein scavengers and smart drug delivery carriers. Dyes and Pigments, (2019). 161.

Cited by 36 publications

References 56 publications

Engineered Nanostructured Materials for Ofloxacin Delivery

Engineered Nanostructured Materials for Ofloxacin Delivery

Application of rare earth-doped nanoparticles in biological imaging and tumor treatment

Quantum Dots: Next Generation of Smart Nano-Systems

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