Sustainably produced cashew gum-capped zinc oxide nanoparticles show antifungal activity against Candida parapsilosis

Souza, Jéssica Maria Teles; Araújo, Alyne Rodrigues de; Carvalho, Andressa Maria Aguiar de; Amorim, Adriany das Graças Nascimento; Daboit, Tatiane Caroline; Leite, José de Souza de Almeida Roberto; Silva, Durcilene Alves da; Eaton, Peter

doi:10.1016/j.jclepro.2019.119085

Cited by 30 publications

(10 citation statements)

References 46 publications

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“…albicans . The antimicrobial activity of some nanomaterials against C. albicans as evaluated by agar diffusion assay in terms of zone diameter were Fluconazole Ag, 26 mm at 20 μL per disk; ZnO, 11 mm at 0.8 μg/mL; ZnO, 11.4 mm at 0.020 μg/mL; and WS 2 /ZnO nanohybrid, 6 mm at 6000 μg/mL.…”

Section: Results and Discussionmentioning

confidence: 99%

“…Recently, WS 2 nanosheets (NS) have been shown to possess antimicrobial activity . Also, Zinc Oxide (ZnO) is declared as “Generally Recognized as Safe” by FDA (21CFR182.8991) and therefore can be used extensively in cosmetics and antifungal creams . Although, in the literature, the antimicrobial and antibiofilm activities of ZnO and WS 2 nanosheets have been studied individually, and the use of WS 2 /ZnO nanohybrids has not been evaluated for the above purpose.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced Antifungal Activity of WS₂/ZnO Nanohybrid against Candida albicans

Bhatt

Patel

Pataniya

et al. 2020

ACS Biomater. Sci. Eng.

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Candida albicans forms persistent infections through the formation of biofilms that confer resistance to existing antifungal drugs. Biofilm targeting is therefore a promising strategy to combat Candida albicans infections. The WS 2 /ZnO nanohybrids exhibits considerably improved antibiofilm activity and inhibited the biofilm formation by 91%, which is quite better than that for pristine WS 2 , which is only 74%. The physical blend prepared by mixing WS 2 nanosheets and WS 2 /ZnO in the ratio of 70:30 showed an antibiofilm activity of 58%, which was intermediate to that observed for pristine materials. The as-synthesized nanohybrid also demonstrates dose-dependent antifungal activity as calculated using the disc diffusion test. WS 2 /ZnO nanohybrid shows 1.5 times higher activity compared to pristine WS 2 nanosheets suggesting that the nanohybrid materials are more effective as novel antifungal materials.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhanced Antifungal Activity of WS₂/ZnO Nanohybrid against Candida albicans

Bhatt

Patel

Pataniya

et al. 2020

ACS Biomater. Sci. Eng.

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“…Due to their small size and unique properties, nanoparticles have been extensively explored in the biomaterials area 105 . In this context, CG has been employed in many different ways, combined with several different compounds, for different purposes.…”

Section: Applications As Biomaterialsmentioning

confidence: 99%

Cashew tree gum for biomaterials engineering: A versatile raw material in consolidation

Moraes

2022

J of Applied Polymer Sci

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In this review, the focus of discussion is the polysaccharide fraction of cashew gum (CG), an exudate of Anacardium occidentale L., a plant typical of hot and humid tropical climates commonly found in northeastern Brazil and from which cashew nuts are extensively commercialized. CG purification, biological activity, and physical–chemical properties are explored in this work, in addition to applications of this biopolymer as a component of biomaterials used to either support, enhance, or replace damaged tissues or improve biological function. Evidence of its successful use to produce a range of biomaterials, from particles to gels and films, and to improve properties of already existing formulations are provided, supporting its versatility in this field of application.

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“…Several nanoscale metal oxides have also been observed to have antifungal properties. Nanoparticles of iron oxide [85][86][87][88], zinc oxide [89][90][91][92][93], magnesium oxide [93][94][95][96], calcium oxide [94,97], copper oxide [98][99][100], titanium dioxide [101][102][103][104], bismuth oxide [105,106], and silver oxide [107] display fungistatic and/or fungicidal activities that are useful in the treatment and prevention of oral candidiasis.…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Biomaterials for the Prevention of Oral Candidiasis Development

et al. 2021

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Thousands of microorganisms coexist within the human microbiota. However, certain conditions can predispose the organism to the overgrowth of specific pathogens that further lead to opportunistic infections. One of the most common such imbalances in the normal oral flora is the excessive growth of Candida spp, which produces oral candidiasis. In immunocompromised individuals, this fungal infection can reach the systemic level and become life-threatening. Hence, prompt and efficient treatment must be administered. Traditional antifungal agents, such as polyenes, azoles, and echinocandins, may often result in severe adverse effects, regardless of the administration form. Therefore, novel treatments have to be developed and implemented in clinical practice. In this regard, the present paper focuses on the newest therapeutic options against oral Candida infections, reviewing compounds and biomaterials with inherent antifungal properties, improved materials for dental prostheses and denture adhesives, drug delivery systems, and combined approaches towards developing the optimum treatment.

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Sustainably produced cashew gum-capped zinc oxide nanoparticles show antifungal activity against Candida parapsilosis

Cited by 30 publications

References 46 publications

Enhanced Antifungal Activity of WS₂/ZnO Nanohybrid against Candida albicans

Enhanced Antifungal Activity of WS₂/ZnO Nanohybrid against Candida albicans

Cashew tree gum for biomaterials engineering: A versatile raw material in consolidation

Biomaterials for the Prevention of Oral Candidiasis Development

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Sustainably produced cashew gum-capped zinc oxide nanoparticles show antifungal activity against Candida parapsilosis

Cited by 30 publications

References 46 publications

Enhanced Antifungal Activity of WS2/ZnO Nanohybrid against Candida albicans

Enhanced Antifungal Activity of WS2/ZnO Nanohybrid against Candida albicans

Cashew tree gum for biomaterials engineering: A versatile raw material in consolidation

Biomaterials for the Prevention of Oral Candidiasis Development

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Product

Resources

About

Enhanced Antifungal Activity of WS₂/ZnO Nanohybrid against Candida albicans

Enhanced Antifungal Activity of WS₂/ZnO Nanohybrid against Candida albicans