Sustained Antibacterial Activity of Doxycycline-Loaded Poly(
            <scp>D</scp>
            ,
            <scp>L</scp>
            -Lactide-Co-Glycolide) and Poly(ε-Caprolactone) Nanoparticles

Misra, Ranjita; Acharya, Sarbari; Dilnawaz, Fahima; Sahoo, Sanjeeb K.

doi:10.2217/nnm.09.28

Cited by 96 publications

(74 citation statements)

References 40 publications

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“…Moreover, the MIC and MBC of NFX-SLN were the same as that of native NFX at 12 h, and lower than that of native NFX at 24 h, suggesting that SLN increased the antibacterial activity of NFX. These results are similar to those obtained by Ranjita Misra et al and Esmaeili et al (Misra et al, 2009;Esmaeili et al, 2007). Fusion of the lipid composition with the bacterial membranes might account for the enhanced antibacterial effect of NFX-SLN (Sachetelli et al, 2000).…”

Section: Antibacterial Activitysupporting

confidence: 90%

Preparation andin vitro,in vivoevaluations of norfloxacin-loaded solid lipid nanopartices for oral delivery

et al. 2011

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Section: Antibacterial Activitysupporting

confidence: 90%

Preparation andin vitro,in vivoevaluations of norfloxacin-loaded solid lipid nanopartices for oral delivery

et al. 2011

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“…36 In this study the zeta potential of a nanoparticle was −20.7 ± 1.2 mV, which was high enough to make the nanoparticles repel each other, thereby avoiding particle aggregation and keeping the long-term stability of nanoparticles. 37,38 Second, X-ray diffraction was used to investigate the nature of curcumin after encapsulation into the SLNs. It was observed that curcumin entrapped in the lipid core of the SLN was in the amorphous or disordered-crystalline phase.…”

Section: Discussionmentioning

confidence: 99%

Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles

Wang

Zhu²,

Xie³

et al. 2012

IJN

174

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Curcumin has shown considerable pharmacological activity, including anti-inflammatory, but its poor bioavailability and rapid metabolization have limited its application. The purpose of the present study was to formulate curcumin-solid lipid n anoparticles (curcumin-SLNs) to improve its therapeutic efficacy in an ovalbumin (OVA)-induced allergic rat model of asthma. A solvent injection method was used to prepare the curcumin-SLNs. Physiochemical properties of curcumin-SLNs were characterized, and release experiments were performed in vitro. The pharmacokinetics in tissue distribution was studied in mice, and the therapeutic effect of the formulation was evaluated in the model. The prepared formulation showed an average size of 190 nm with a zeta potential value of −20.7 mV and 75% drug entrapment efficiency. X-ray diffraction analysis revealed the amorphous nature of the encapsulated curcumin. The release profile of curcumin-SLNs was an initial burst followed by sustained release. The curcumin concentrations in plasma suspension were significantly higher than those obtained with curcumin alone. Following administration of the curcumin-SLNs, all the tissue concentrations of curcumin increased, especially in lung and liver. In the animal model of asthma, curcumin-SLNs effectively suppressed airway hyperresponsiveness and inflammatory cell infiltration and also significantly inhibited the expression of T-helper-2-type cytokines, such as interleukin-4 and interleukin-13, in bronchoalveolar lavage fluid compared to the asthma group and curcumin-treated group. These observations implied that curcumin-SLNs could be a promising candidate for asthma therapy.

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“…[31][32][33] Previous studies throughout the literature have applied lipid-based approaches (liposomes, solid lipid nanoparticles, nanoemulsions, and microemulsions) and polymerbased nanocarriers (nanocapsules and nanospheres) to enhance the antimicrobial activity of antibiotics (including β-lactams). [34][35][36][37][38][39] Nanoantimicrobial agent synthesis studies have recently increased in number; however, most of these agents are nonantibiotic-based nanoparticles, primarily metal-based nanoparticles that use silver, copper, and zinc, among other metals. This study aimed to prepare the first amp-chitosan-iron oxide nanocomposite for numerous applications such as a novel nanoantibiotic pharmaceutical agent to combat various bacterial diseases.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and antimicrobial activity of an ampicillin-conjugated magnetic nanoantibiotic for medical applications

Hussein‐Al‐Ali¹,

Zowalaty²,

Hussein³

et al. 2014

IJN

104

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Because of their magnetic properties, magnetic nanoparticles (MNPs) have numerous diverse biomedical applications. In addition, because of their ability to penetrate bacteria and biofilms, nanoantimicrobial agents have become increasingly popular for the control of infectious diseases. Here, MNPs were prepared through an iron salt coprecipitation method in an alkaline medium, followed by a chitosan coating step (CS-coated MNPs); finally, the MNPs were loaded with ampicillin (amp) to form an amp-CS-MNP nanocomposite. Both the MNPs and amp-CS-MNPs were subsequently characterized and evaluated for their antibacterial activity. X-ray diffraction results showed that the MNPs and nanocomposites were composed of pure magnetite. Fourier transform infrared spectra and thermogravimetric data for the MNPs, CS-coated MNPs, and amp-CS-MNP nanocomposite were compared, which confirmed the CS coating on the MNPs and the amp-loaded nanocomposite. Magnetization curves showed that both the MNPs and the amp-CS-MNP nanocomposites were superparamagnetic, with saturation magnetizations at 80.1 and 26.6 emu g −1 , respectively. Amp was loaded at 8.3%. Drug release was also studied, and the total release equilibrium for amp from the amp-CS-MNPs was 100% over 400 minutes. In addition, the antimicrobial activity of the amp-CS-MNP nanocomposite was determined using agar diffusion and growth inhibition assays against Gram-positive bacteria and Gram-negative bacteria, as well as Candida albicans . The minimum inhibitory concentration of the amp-CS-MNP nanocomposite was determined against bacteria including Mycobacterium tuberculosis . The synthesized nanocomposites exhibited antibacterial and antifungal properties, as well as antimycobacterial effects. Thus, this study introduces a novel β-lactam antibacterial-based nanocomposite that can decrease fungus activity on demand for numerous medical applications.

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Sustained Antibacterial Activity of Doxycycline-Loaded Poly( D , L -Lactide-Co-Glycolide) and Poly(ε-Caprolactone) Nanoparticles

Cited by 96 publications

References 40 publications

Preparation andin vitro,in vivoevaluations of norfloxacin-loaded solid lipid nanopartices for oral delivery

Preparation andin vitro,in vivoevaluations of norfloxacin-loaded solid lipid nanopartices for oral delivery

Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles

Synthesis, characterization, and antimicrobial activity of an ampicillin-conjugated magnetic nanoantibiotic for medical applications

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