Sustained ophthalmic delivery of gatifloxacin from<i>In situ</i>gelling system

Doijad, RC; Manvi, F. V.; Rao, V.S.N Malleswara; Alase, Prajakta

doi:10.4103/0250-474x.31025

Cited by 23 publications

(15 citation statements)

References 7 publications

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“…These gel matrices are also capable of releasing and prolonging the residence time of drugs in a controlled manner (Doijad et al, 2006). In situ gels are administered through oral, injectable, rectal, ocular, vaginal and intra-peritoneal routes (Hatefi & Amesden, 2002).…”

Section: Introductionmentioning

confidence: 99%

Controlled release of injectable liposomalin situgel loaded with recombinant human bone morphogenetic protein-2 for the repair of alveolar bone clefts in rabbits

Hassan

Hosny

Murshid

et al. 2015

Journal of Liposome Research

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Section: Introductionmentioning

confidence: 99%

Controlled release of injectable liposomalin situgel loaded with recombinant human bone morphogenetic protein-2 for the repair of alveolar bone clefts in rabbits

Hassan

Hosny

Murshid

et al. 2015

Journal of Liposome Research

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“…The preliminary batches of 0.05% Epinastine hydrochloride were formulated using Carbopol 974, HPMC E-50LV, Benzalkonium chloride, buffering agent and disodium edetate 5 . The batches were evaluated for in vitro in situ gelation in Artificial Tear Fluid (ATF) and for viscosity to optimize the concentration of Carbopol 974 and HPMC E-50LV for final formulation as shown in Table 1.…”

Section: Preliminary Studymentioning

confidence: 99%

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2016

IJPSR

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ABSTRACT:The poor bioavailability of ophthalmic solutions caused by dilution and drainage from the eye can be overcome by using in situ forming ophthalmic drug delivery system prepared from polymer that exhibit reversible liquid-gel phase transition. The objective of the study was to develop optimized formulation of in situ ophthalmic gel of Epinastine hydrochloride, an antihistaminic drug, using a pH triggered polymer, Carbopol as a gelling polymer and HPMC E-50LV (hydroxyl propyl methyl cellulose) as release retardant. The 32 full factorial design was employed to optimize the formulation considering Carbopol and HPMC as independent variables. The formulations were assessed for appearance, gelling ability, sterility, pH, drug content, viscosity, release through cellophane membrane & corneal membrane of goat, ocular irritation study & stability study as per ICH guidelines. Formulations F3 and F7 were found to be the good formulations from the nine formulations developed by 32 factorial design. The study revealed that the in situ system of epinastine hydrochloride sustained the effect of drug to 12 hours. The formulations F3 and F7 extended the release of drug upto 12 hours as compare to marketed product (EPINA eye drops) which released 99.22% release within 6hrs.

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“…The results were the means of three runs. [14] Percent cumulative drug release of optimized formulations (F2, F5, and F11) is shown in Figure 13.…”

Section: In Vitro Transcorneal Permeation Studymentioning

confidence: 99%

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Mhetre¹

2016

AJP

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Aim: The present work describes the formulation and evaluation of thermoreversible in situ gel of brimonidine tartrate (BRT) by incorporating penetration enhancers such as Surfactant (Tween 20), Chelating agent (Disodium EDTA), Bile salt (Sodium tourocholate) in various percentage strength in combination with viscosifying agent to improve ocular bioavailability of drug, which will also improve corneal contact time and corneal permeation of drug. Materials and Methods: Thermoreversible ophthalmic gel were prepared by using Cold method by mixing Poloxamer 407 as a thermosensitive polymer, HPMC K4M as viscosifying agent, antiglaucomic drug BRT, Benzalkonium chloride as preservatives and one of the three penetration enhancers use alternatively. A 22 factorial design employed for optimization of BRT gels with HPMC K4M (% X1) and penetration enhancer (% X2) as the prime selected independent variable, which were varied at 2 different levels (low and high). Result and Discussion: Raising concentration of penetration enhancers at the certain limit increase in vitro permeation through goat cornea. At 0.5% w/v concentration of penetration enhancers increase percent drug content, improve apparent permeability coefficient of formulation, and gelation temperature, significantly (P < 0.05). The result revealed that optimized formulation containing Tween 20 as penetration enhancers show dominant increase in permeation of drug. Conclusion: The study reflects that the permeation of BRT influenced by various penetration enhancers concentration and also viscosifying agent, permeation was found to be concentration dependent.

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Sustained ophthalmic delivery of gatifloxacin fromIn situgelling system

Cited by 23 publications

References 7 publications

Controlled release of injectable liposomalin situgel loaded with recombinant human bone morphogenetic protein-2 for the repair of alveolar bone clefts in rabbits

Controlled release of injectable liposomalin situgel loaded with recombinant human bone morphogenetic protein-2 for the repair of alveolar bone clefts in rabbits

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