1978
DOI: 10.1002/jps.2600670321
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Sustained Release from Inert Wax Matrixes II: Effect of Surfactants on Tripelennamine Hydrochloride Release

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1978
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Cited by 36 publications
(11 citation statements)
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“…Bees wax and cetyl alcohol can be used for sustained release of metformin HCl. The mechanism of drug release from wax matrices has been a matter of controversy since wax matrices tend to be more heterogeneous than other matrices (Dakkuri A et al 1978). The study reveals that, the release of water soluble drug, metformin HCl exhibited diffusion dominated mechanism.…”
Section: Resultsmentioning
confidence: 92%
“…Bees wax and cetyl alcohol can be used for sustained release of metformin HCl. The mechanism of drug release from wax matrices has been a matter of controversy since wax matrices tend to be more heterogeneous than other matrices (Dakkuri A et al 1978). The study reveals that, the release of water soluble drug, metformin HCl exhibited diffusion dominated mechanism.…”
Section: Resultsmentioning
confidence: 92%
“…Firstly, it is possible that the surfactant lowers the interfacial tension between the product and the dissolution fluid; secondly, it is possible that the surfactant acts as a wicking agent, causing the fluid to enter the dosage form; the surfactant may then dissolve and form pores (or other disruptions) from which the drug release may be affected (21). The same results were reported on the effect of surfactants on the dissolution profiles of flurbiprofen (22).…”
Section: And Discussionmentioning
confidence: 56%
“…Two possible mechanisms have been postulated as to why surfactants increase the rate of drug release from matrix formulations (21,22). Firstly, it is possible that the surfactant lowers the interfacial tension between the product and the dissolution fluid; secondly, it is possible that the surfactant acts as a wicking agent, causing the fluid to enter the dosage form; the surfactant may then dissolve and form pores (or other disruptions) from which the drug release may be affected (21).…”
Section: And Discussionmentioning
confidence: 99%
“…a-e The triangular-dimensional contour diagrams illustrating the effect of HVO, NaCMC, and MCC on the release of Cilostazol; a 1-h drug release percent, b 4-h drug release percent, c 8-h drug release percent, d 12-h drug release percent, and e overlay plot kind of matrixes. For example, in some cases, it has been reported that the mechanism of release from wax matrices involves the leaching of drug by the eluting medium, while others indicated that it is diffusion controlled and is best described by Higuchi model (30,38). In the current study, the release exponent (n) of the optimized solid dispersion based disintegration mediated wax matrix (Global solution observed; GS o ) was 0.85 (r 2 =0.999 and K=0.132), suggesting a non-Fickian (anomalous) release, with reasonably an equal preponderance of the diffusion and zero-order mechanisms.…”
Section: Release Rate Kineticsmentioning
confidence: 99%