Sustained release micellar carrier systems for iontophoretic transport of dexamethasone across human sclera

Chopra, Poonam; Hao, Jinsong; Li, S. Kevin

doi:10.1016/j.jconrel.2012.01.032

Cited by 61 publications

(37 citation statements)

References 39 publications

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“…Another alternative is the design of nanogels based on similar polymers for administration using narrow gauge needles. Other nanomedicines including liposomes (Fujisawa et al, 2012; M et al, 2012), micelles (Chopra et al, 2012), and dendrimers (Durairaj et al, 2010; Iezzi et al, 2012) have also demonstrated potential in sustaining drug release.…”

Section: Applications Of Nanotechnology For Back Of the Eye Diseasesmentioning

confidence: 99%

Nanomedicines for back of the eye drug delivery, gene delivery, and imaging

Kompella

Amrite

Ravi

et al. 2013

Progress in Retinal and Eye Research

227

123

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Treatment and management of diseases of the posterior segment of the eye such as diabetic retinopathy, retinoblastoma, retinitis pigmentosa, and choroidal neovascularization is a challenging task due to the anatomy and physiology of ocular barriers. For instance, traditional routes of drug delivery for therapeutic treatment are hindered by poor intraocular penetration and/or rapid ocular elimination. One possible approach to improve ocular therapy is to employ nanotechnology. Nanomedicines, products of nanotechnology, having at least one dimension in the nanoscale include nanoparticles, micelles, nanotubes, and dendrimers, with and without targeting ligands, are making a significant impact in the fields of ocular drug delivery, gene delivery, and imaging, the focus of this review. Key applications of nanotechnology discussed in this review include a) bioadhesive nanomedicines; b) functionalized nanomedicines that enhance target recognition and/or cell entry; c) nanomedicines capable of controlled release of the payload; d) nanomedicines capable of enhancing gene transfection and duration of transfection; f) nanomedicines responsive to stimuli including light, heat, ultrasound, electrical signals, pH, and oxidative stress; g) diversely sized and colored nanoparticles for imaging, and h) nanowires for retinal prostheses. Additionally, nanofabricated delivery systems including implants, films, microparticles, and nanoparticles are described. Although the above nanomedicines may be administered by various routes including topical, intravitreal, intravenous, transscleral, suprachoroidal, and subretinal routes, each nanomedicine should be tailored for the disease, drug, and site of administration. In addition to the nature of materials used in nanomedicine design, depending on the site of nanomedicine administration, clearance and toxicity are expected to differ.

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Section: Applications Of Nanotechnology For Back Of the Eye Diseasesmentioning

confidence: 99%

Nanomedicines for back of the eye drug delivery, gene delivery, and imaging

Kompella

Amrite

Ravi

et al. 2013

Progress in Retinal and Eye Research

227

123

View full text Add to dashboard Cite

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“…13,16 Recently, polymeric micelles have been used for ocular drug delivery to improve the drug release. 17,18 Drug-loaded polymeric micelles offer favorable biological properties, such as biocompatibility, biodegradability, mucoadhesiveness, nontoxicity, and controlled drug release. 19 Topical formulations of drug-loaded polymeric micelles hold significant promise for ophthalmic drug delivery.…”

Section: Introductionmentioning

confidence: 99%

“…29,36 At present, there are numerous reports discussing the ocular penetration of drugs. 8,9,18,37 To the best of our knowledge, this novel biometry method was used for the first time in vivo to clearly visualize the penetration behaviors of drugs into the corneas of BALB/c mice.…”

mentioning

confidence: 99%

Positively charged micelles based on a triblock copolymer demonstrate enhanced corneal penetration

Li¹,

Li²,

Zhou³

et al. 2015

IJN

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Purpose The cornea is a main barrier to drug penetration after topical application. The aim of this study was to evaluate the abilities of micelles generated from a positively charged triblock copolymer to penetrate the cornea after topical application. Methods The triblock copolymer poly(ethylene glycol)-poly(ε-caprolactone)- g -polyethyleneimine was synthesized, and the physicochemical properties of the self-assembled polymeric micelles were investigated, including hydrodynamic size, zeta potential, morphology, drug-loading content, drug-loading efficiency, and in vitro drug release. Using fluorescein diacetate as a model drug, the penetration capabilities of the polymeric micelles were monitored in vivo using a two-photon scanning fluorescence microscopy on murine corneas after topical application. Results The polymer was successfully synthesized and confirmed using nuclear magnetic resonance and Fourier transform infrared. The polymeric micelles had an average particle size of 28 nm, a zeta potential of approximately +12 mV, and a spherical morphology. The drug-loading efficiency and drug-loading content were 75.37% and 3.47%, respectively, which indicates that the polymeric micelles possess a high drug-loading capacity. The polymeric micelles also exhibited controlled-release behavior in vitro. Compared to the control, the positively charged polymeric micelles significantly penetrated through the cornea. Conclusion Positively charged micelles generated from a triblock copolymer are a promising vehicle for the topical delivery of hydrophobic agents in ocular applications.

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“…In general, iontophoresis contributes to drug delivery mainly by electromigration, which is the orderly movement of ions in the presence of an electrical current, and electroosmosis, which is convective solvent flow in the anode-to-cathode direction that occurs under physiological conditions when the epithelium is nega-Therefore, nanocarriers have been evaluated with iontophoresis to provide sustained drug delivery in different regions of the eye [16]. Currently, iontophoretic transport of two different nanocarriers has been studied: 1) cationic-and anionic-fluorescent-modified polystyrene nanospheres (FluoSpheres®) of approximately 20 nm (anionic) and 40 nm (cationic) were studied to explore the contribution of electromigration to their transcorneal and transcleral delivery [16] and 2) anionic micelles of approximately 4.5 nm in size were studied to explore their potential to prolong dexamethasone (Dex) delivery using cathodal transcleral iontophoresis [14].…”

Section: Introductionmentioning

confidence: 99%