Sustained release nanofibrous composite patch for transdermal antibiotic delivery

Nematpour, Najmeh; Farhadian, Negin; Ebrahimi, Kosar Sadat; Arkan, Elham; Seyedi, Faranak; Khaledian, Salar; Shahlaei, Mohsen; Moradi, Sajad

doi:10.1016/j.colsurfa.2019.124267

Cited by 30 publications

(10 citation statements)

References 34 publications

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“…At the same time, the increased ratio of PCL in PCL/Col nanofibers restricts the entry of water into the nanofibers, causing difficulty in the solubilization of ART and Col in water. Overall, the above phenomenon was caused by the increase in hydrophobic PCL content in the PCL/Col nanofibers [ 52 ]. As the proportion of PCL in PCL/Col nanofibers increased, the hydrophilicity of the nanofibers decreased and the hydrophobicity increased, which may slow down the release of ART from ART-loaded PCL/Col nanofibers.…”

Section: Resultsmentioning

confidence: 99%

Electrospun Nanofibers of Polycaprolactone/Collagen as a Sustained-Release Drug Delivery System for Artemisinin

et al. 2021

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The application of artemisinin (ART) in the treatment of malaria has been restricted to a certain degree due to its inherent limitations, such as short half-life, poor solubility, limited bioavailability, and re-crystallization. Electrospun nanofibers loaded with ART provide an excellent solution to these limitations and yield sustained drug release as well as inhibition of drug re-crystallization. In this study, ART-loaded polycaprolactone (PCL)/collagen (Col) nanofibers with different proportions of polymers were prepared. ART-loaded PCL/Col nanofibers were characterized, and further ART anti-crystallization and release behaviors were studied. SEM was used to observe the morphology of PCL/Col nanofibers. X-ray diffraction (XRD) was used to characterize the physical state of ART in ART-loaded PCL/Col nanofibers. Fourier transform infrared spectroscopy (FTIR), water contact angle measurement, weight loss, degree of swelling, and drug release experiments can verify the differences in performance of ART-loaded PCL/Col nanofibers due to different polymer ratios. The release curve was analyzed by kinetics, showing sustained release for up to 48 h, and followed the Fickian release mechanism, which was shown by the diffusion index value obtained from the Korsmeyer-Peppas equation.

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Section: Resultsmentioning

confidence: 99%

Electrospun Nanofibers of Polycaprolactone/Collagen as a Sustained-Release Drug Delivery System for Artemisinin

et al. 2021

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“…The electrospinning process is the most suitable technique for drug delivery and tissue engineering applications of PCL-based nanocomposite fibers [ 11 , 12 , 13 , 14 ]. The electrospinning process, belonging to the electro-hydrodynamic processing [ 14 ], can consistently produce a wide variety of woven non-woven mat starting from polymeric solutions exposed to high electric fields that offer large surface areas, small inter-fibrous pore size, and high porosity [ 15 , 16 , 17 , 18 ], with interest in the biomedical field since they mimic the structure of extracellular matrix [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Organic and Inorganic PCL-Based Electrospun Fibers

et al. 2020

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In this work, different nanocomposite electrospun fiber mats were obtained based on poly(e-caprolactone) (PCL) and reinforced with both organic and inorganic nanoparticles. In particular, on one side, cellulose nanocrystals (CNC) were synthesized and functionalized by “grafting from” reaction, using their superficial OH– group to graft PCL chains. On the other side, commercial chitosan, graphene as organic, while silver, hydroxyapatite, and fumed silica nanoparticles were used as inorganic reinforcements. All the nanoparticles were added at 1 wt% with respect to the PCL polymeric matrix in order to compare the different behavior of the woven no-woven nanocomposite electrospun fibers with a fixed amount of both organic and inorganic nanoparticles. From the thermal point of view, no difference was found between the effect of the addition of organic or inorganic nanoparticles, with no significant variation in the Tg (glass transition temperature), Tm (melting temperature), and the degree of crystallinity, leading in all cases to high crystallinity electrospun mats. From the mechanical point of view, the highest values of Young modulus were obtained when graphene, CNC, and silver nanoparticles were added to the PCL electrospun fibers. Moreover, all the nanoparticles used, both organic and inorganic, increased the flexibility of the electrospun mats, increasing their elongation at break.

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“…This dual system was found to facilitate tissue regeneration, while preventing infection at the transplant site. [ 141 ] Similarly, thymoquinone and antibiotic tetracycline hydrochloride [ 142 ] were incorporated into 3D electrospun scaffolds and prevented common clinical infections and promoted healing. [ 143 ] Several other antibacterial materials, such as the peptide OH‐CATH30 (OH‐30), [ 144 ] CS, [ 145 ] medicinal plant extracts, [ 146 ] and silver nanoparticles, [ 147 ] have likewise been investigated for this purpose, with promising results.…”

Section: Tissue Regeneration Based On 3d Electrospun Scaffoldsmentioning

confidence: 99%

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

Toftdal

Friec

et al. 2021

Small Science

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Tissue regeneration is a rapidly evolving and interdisciplinary field at the intersection of life science, biology, material science, and engineering. Centrally, it involves functional cell-free or cell-laden constructs or biomaterial scaffolds that are fabricated utilizing various strategies. [1] Cell-free biomaterial scaffolds implanted directly at the sites of injury may mechanically support local cells to promote local tissue repair. [2] Furthermore, they can be functionalized both on the surface or in the interior with bioactive materials to stimulate regeneration of functional tissues. [3] In cell therapy applications, cell-laden constructs may enhance both survival and differentiation of the therapeutic cells compared with cell transplantation alone. The grafted cells may then ideally replace lost tissue and/or exert beneficial effects on the host tissue. [4] Among different biomaterial constructs, 3D fibrous scaffolds recreate a 3D microenvironment, which closely resembles the native extracellular matrix (ECM), including both structural and biochemical properties that guide cell survival and differentiation. [5] Scaffolds with fibrous networks possess unique characteristics, including sufficiently high interconnected porosity, high specific surface area, tunable mechanical properties, as well as optimal morphological features. The high porosity of the fibrous scaffolds facilitates mass transfer for effective nutrient supply, oxygen diffusion, metabolic waste removal, and enhancement of intercellular communications, consequently allowing high cell viability and function throughout the entire scaffold. [6] In addition, compared with 2D culture, the 3D cell culture provides a more realistic biochemical and biomechanical microenvironment, [7] creating an optimal environment for cell migration, proliferation, and differentiation. Hence, nanofibrous scaffolds with appropriate biomechanical properties are highly suitable for tissue engineering. [8] Electrospinning, as a relatively simple and versatile fiber preparation technique, has been developed to create fiber-based constructs in combination with cells, bioactive molecules, proteins, and biocompatible nanomaterials. [9] Many studies have demonstrated that the electrospinning technology has the potential for significant progress within the field of tissue regeneration. Chen et al. [10] summarized the methods for producing electrospun 1D nanofiber bundles, 2D

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Sustained release nanofibrous composite patch for transdermal antibiotic delivery

Cited by 30 publications

References 34 publications

Electrospun Nanofibers of Polycaprolactone/Collagen as a Sustained-Release Drug Delivery System for Artemisinin

Electrospun Nanofibers of Polycaprolactone/Collagen as a Sustained-Release Drug Delivery System for Artemisinin

Organic and Inorganic PCL-Based Electrospun Fibers

3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration

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